References

nodgo

Российский журнал детской гематологии и онкологии (РЖДГиО)

Russian Journal of Pediatric Hematology and Oncology

2311-12672413-5496

LTD “Graphica”

10.17650/2311-1267-2015-2-2-28-42

nodgo-100

Research Article

ИЗБРАННЫЕ ЛЕКЦИИ

SELECTED LECTURES

АЛЛОГЕННАЯ ТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК У ДЕТЕЙ: НАСТОЯЩЕЕ, ПРОБЛЕМЫ, ПЕРСПЕКТИВЫ

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN: NOW, PROBLEMS AND PROSPECTS

Афанасьев

Б. В.

Afanasiev

B. V.

Зубаровская

Л. С.

Zubarovskaya

L. S.

bmt@spb-gmu.ru

Моисеев

И. С.

Moiseev

I. S.

Научно-исследовательский институт детской онкологии, гематологии и трансплантологии им. Р. М. Горбачевой ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Минздрава России; Россия, 197022, Санкт-Петербург, ул. Рентгена, 12РоссияRaisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St.Petersburg, Ministry of Health of Russia; 12 Rentgena St., Saint Petersburg, 197022, RussiaRussian Federation

2015

29052015

222842

2015

Афанасьев Б.В., Зубаровская Л.С., Моисеев И.С.

Afanasiev B.V., Zubarovskaya L.S., Moiseev I.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.nodgo.org/jour/article/view/100

Трансплантация гемопоэтических стволовых клеток (ТГСК) является ведущим методом лечения злокачественных заболеваний системы крови и наследственных заболеваний, а также ряда солидных опухолей у детей, подразделяется на аутологичную (ауто-ТГСК) и аллогенную (алло-ТГСК) трансплантации. Проведение ТГСК осуществляется с учетом показаний, наличия донора – родственного, неродственного, гаплоидентичного, с применением режимов кондиционирования различной интенсивности (миело аблативные, режимы кондиционирования сниженной интенсивности доз, немиелоаблативные), профилактики реакции «трансплантат против хозяина», которая является ведущим осложнением. Наряду с цитостатическим воздействием при выполнении алло-ТГСК осуществляется иммуноадоптивный эффект – «трансплантат против лейкоза».

Hematopoietic stem cells transplantation (HSCT) is a potentially curative method for patients suffering from different oncological, hemato-logical and inherited diseases. Two variants of these procedures are autologous (аuto-HSCT) and allogeneic (аllо-HSCT) transplantation. Indications, availability of donor (related, unrelated, haploidentical), conditioning regimen (myeloablative, reduce intensity conditioning regimens, non-myeloablative), methods of “graft versus host disease” prophylaxis are taken into account when performing HSCT. In allo-HSCT “graft versus leukemia” effect develops and it is the platform for providing of immunoadoptive therapy.

аллогенная трансплантация гемопоэтических стволовых клеток у детейвидыисточникипоказанияэффективностьосложненияперспективы

allogeneic hematopoietic stem cell transplantation in childrenprospectssourcesindicationsefficiencycomplicationspossibility

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The authors declare that there are no conflicts of interest present.