nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2024-11-2-61-66nodgo-1040Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSРоль тромбоцитов в гематогенном метастазировании опухолейRole of platelets in hematogenous metastasis of tumorshttps://orcid.org/0000-0001-8088-1749КраличкинП. В.KralichkinP. V.

Павел Викторович Краличкин: врач-детский онколог стационара кратковременного лечения

117997, Москва, ул. Саморы Машела, 1

Pediatric Oncologist of the Hospital for Short-Term Treatment

1 Samory Mashela St., Moscow, 117997

pavel.kralichkin@fccho-moscow.ruhttps://orcid.org/0000-0002-3704-8783КачановД. Ю.KachanovD.  Yu.

д.м.н., заместитель директора Института онкологии, радиологии и ядерной медицины и заведующий отделением клинической онкологии

117997, Москва, ул. Саморы Машела, 1

Dr. of Sci. (Med.), Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine & Head of the Department of Clinical Oncology

1 Samory Mashela St., Moscow, 117997

Denis.Kachanov@fccho-moscow.ruhttps://orcid.org/0000-0002-2057-2036ПшонкинА. В.PshonkinA. V.

к.м.н., врач-гематолог, врач-детский онколог, заведующий стационаром кратковременного лечения

117997, Москва, ул. Саморы Машела, 1

Cand. of Sci. (Med.), Hematologist, Pediatric Oncologist, Head of the Hospital for Short-Term Treatment

1 Samory Mashela St., Moscow, 117997

alexey.pshonkin@gmail.comhttps://orcid.org/0000-0003-4384-6754ЖарковП. А.ZharkovP. A.

д.м.н., врач-педиатр, врач-гематолог консультативного отделения, заведующий отделом патологии гемостаза

Web of Science ResearcherID: AAP-9203-2020

117997, Москва, ул. Саморы Машела, 1

Dr. of Sci. (Med.), Pediatrician, Hematologist Outpatient Consultative Unit, Head of the Hemostasis Pathology Department

Web of Science ResearcherID: AAP-9203-2020

1 Samory Mashela St., Moscow, 117997

pavel.zharkov@fccho-moscow.ruФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation2024120820241126166Copyright © Краличкин П.В., Качанов Д.Ю., Пшонкин А.В., Жарков П.А., 20242024Краличкин П.В., Качанов Д.Ю., Пшонкин А.В., Жарков П.А.Kralichkin P.V., Kachanov D.Y., Pshonkin A.V., Zharkov P.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/1040

Общеизвестными функциями тромбоцитов являются участие в системе гемостаза и тромбообразование, которые в свою очередь исполняются путем их адгезии к поврежденным тканям, а также агрегации между собой с образованием гемостатической пробки, перекрывающей повреждение. Способности к адгезии и агрегации тромбоцитов определяются их специфическими мембранными гликопротеинами.

Однако функционал тромбоцитов не ограничивается исключительно тромбообразованием. К примеру, имеются данные об использовании опухолевыми клетками тромбоцитов для осуществления метастазирования. Настоящая публикация обобщает международную литературу, посвященную роли тромбоцитов в гематогенном метастазировании опухолей.

The well-known functions of platelets are participation in the hemostasis system and thrombosis, which, in turn, are performed by their adhesion to damaged tissues, as well as aggregation among themselves with the formation of a hemostatic plug that covers the lesion. The adhesion and aggregation abilities of platelets are determined by their specific membrane glycoproteins.

However, platelet functionality is not limited solely to thrombosis. For example, there is evidence for the use of platelets by tumor cells to effect metastasis. This publication summarizes the international literature on the role of platelets in hematogenous tumor metastasis.

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The authors declare that there are no conflicts of interest present.