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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21682/2311-1267-2025-12-3-14-2</article-id><article-id custom-type="elpub" pub-id-type="custom">nodgo-1185</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Оценка трансфузионной потребности реципиентов аллогенной трансплантации гемопоэтических стволовых клеток и факторов, влияющих на нее</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of transfusion requirements of allogeneic haematopoietic stem cell transplantation recipients and factors influencing it</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9881-1041</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кумукова</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kumukova</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Борисовна Кумукова - к.м.н., заведующая отделением трансфузиологии ММКЦ «Коммунарка», научный сотрудник НМИЦ ДГОИ им. Дмитрия Рогачева, доцент кафедры гематологии и трансфузиологии им. акад. И.А. Кассирского и А.И. Воробьева РМАНПО.</p><p>117997, Москва, ул. Саморы Машела, 1; 108814, Москва, пос. Коммунарка, ул. Сосенский стан, 8; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Head of the Transfusion Department of the “Kommunarka” Moscow Multidisciplinary Clinical Center of the Department of Health in Moscow, Researcher at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, MHR, Docent of the Department of Hematology and Transfusiology named after Academicians I.A. Kassirsky and A.I. Vorobyov, Russian Medical Academy of Continuous Professional Education, MHR.</p><p>1 Samory Mashela St., Moscow, 117997; 8 Sosensky Stan St., Kommunarka, Moscow, 108814; Bldg. 1, 2/1 Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">irina_kumukova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1219-8654</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старостин</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Starostin</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач-трансфузиолог отделения трансфузиологии, заготовки и процессинга гемопоэтических стволовых клеток НМИЦ ДГОИ им. Дмитрия Рогачева.</p><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>Transfusiologist, Transfusiology Department of the Harvesting and Processing of Hemopoietic Stem Cells at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, MHR.</p><p>1 Samory Mashela St., Moscow, 117997</p></bio><email xlink:type="simple">nikolai.starostin@fccho-moscow.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-2035-999X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедов</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач-трансфузиолог отделения трансфузиологии ММКЦ «Коммунарка».</p><p>108814, Москва, пос. Коммунарка, ул. Сосенский стан, 8</p></bio><bio xml:lang="en"><p>Transfusiologist, Transfusiology Department of the “Kommunarka” Moscow Multidisciplinary Clinical Center of the Department of Health in Moscow.</p><p>8 Sosensky Stan St., Kommunarka, Moscow, 108814</p></bio><email xlink:type="simple">Eltun.m@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8562-8945</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Процветкина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Protsvetkina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Специалист отдела биостатистики НМИЦ ДГОИ им. Дмитрия Рогачева.</p><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>Specialist, Biostatistics Department of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, MHR.</p><p>1 Samory Mashela St., Moscow, 117997</p></bio><email xlink:type="simple">a.procvetkina@dgoi.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2689-0569</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балашов</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Balashov</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующий отделением трансплантации гемопоэтических стволовых клеток № 2 НМИЦ ДГОИ им. Дмитрия Рогачева.</p><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>Dr. of Sci (Med.), Head of the Haematopoietic Stem Cell Transplantation Department No 2 of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, MHR.</p><p>1 Samory Mashela St., Moscow, 117997</p></bio><email xlink:type="simple">balashov.dn@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0231-1617</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трахтман</surname><given-names>П. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Trakhtman</surname><given-names>P. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующий отделением трансфузиологии, заготовки и процессинга гемопоэтических стволовых клеток НМИЦ ДГОИ им. Дмитрия Рогачева, профессор кафедры гематологии и трансфузиологии им. акад. И.А. Кассирского и А.И. Воробьева РМАНПО.</p><p>117997, Москва, ул. Саморы Машела, 1; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Head of the Transfusiology Department of the Harvesting and Processing of Hemopoietic Stem Cells at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, MHR, Professor of the Department of Hematology and Transfusiology named after Academicians I.A. Kassirsky and A.I. Vorobyov, Russian Medical Academy of Continuous Professional Education, MHR.</p><p>1 Samory Mashela St., Moscow, 117997; Bldg. 1, 2/1 Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">trakhtman@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева» Минздрава России; ГБУЗ «Московский многопрофильный клинический центр «Коммунарка» Департамента здравоохранения города Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; “Kommunarka” Moscow Multidisciplinary Clinical Center of the Department of Health in Moscow; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Московский многопрофильный клинический центр «Коммунарка» Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>“Kommunarka” Moscow Multidisciplinary Clinical Center of the Department of Health in Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2025</year></pub-date><volume>12</volume><issue>3</issue><fpage>14</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кумукова И.Б., Старостин Н.Н., Мамедов Э.А., Процветкина А.В., Балашов Д.Н., Трахтман П.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кумукова И.Б., Старостин Н.Н., Мамедов Э.А., Процветкина А.В., Балашов Д.Н., Трахтман П.Е.</copyright-holder><copyright-holder xml:lang="en">Kumukova I.B., Starostin N.N., Mamedov E.A., Protsvetkina A.V., Balashov D.N., Trakhtman P.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/1185">https://journal.nodgo.org/jour/article/view/1185</self-uri><abstract><sec><title>Введение</title><p>Введение. Аллогенная трансплантация гемопоэтических стволовых клеток (ТГСК) активно применяется в клинической практике для лечения различных заболеваний. Реципиенты аллогенной ТГСК нуждаются в значительных объемах трансфузионной терапии, однако реальные потребности в трансфузиях и факторы, влияющие на нее, не оценивались в отечественной практике.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен ретроспективный анализ потребности в трансфузиях различных компонентов донорской крови реципиентов первой аллогенной ТГСК, выполненной в 2018–2022 гг., в течение 1 года наблюдения. Объемы выполненных трансфузий рассчитаны для каждого вида компонентов крови. Трансфузионно зависимый период представлен количеством дней до достижения критериев независимости от трансфузии. В работе приведена частота утраты независимости от трансфузий, оценено влияние различных факторов на трансфузионную потребность и независимость от трансфузий.</p><p>Результаты и их обсуждение. Медиана количества трансфузий эритроцитных компонентов донорской крови составила 2 (межквартильный размах 1–4), концентратов тромбоцитов – 5 (межквартильный размах 3–10). Единственным фактором, оказавшим влияние на объемы трансфузионной терапии, являлся тип диагноза – при незлокачественных заболеваниях требовалось больше трансфузий. На длительность трансфузионно зависимого периода оказывали влияние тип диагноза, источник гемопоэтических стволовых клеток и тип донора. Гендерные различия между донором и реципиентом, как и различия по антигенам системы АВО и режим кондиционирования, не оказывали влияния ни на трансфузионную потребность, ни на независимость от трансфузий.</p></sec><sec><title>Заключение</title><p>Заключение. В данном анализе представлена потребность в трансфузиях компонентов донорской крови реципиентов аллогенной ТГСК в течение 1 года. Результаты анализа могут быть использованы для планирования деятельности центров трансплантации и учреждений службы крови для обеспечения трансфузионной поддержки реципиентов ТГСК.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Allogeneic haematopoietic stem cell transplantation (HSCT) is actively used in clinical practice for the treatment of various diseases. Recipients of allogeneic HSCT require significant amounts of transfusion therapy, but the real need for transfusions and factors influencing this need have not been assessed in domestic practice.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A retrospective analysis of the need for transfusions of blood components of recipients of the first allogeneic HSCT performed in 2018–2022 during the observation period of 1 year was performed. The volumes of transfusions performed were calculated for each type of blood components. The transfusion-dependent period is represented by the number of days until the transfusion independence criteria were reached. The incidence of loss of transfusion independence is presented. The influence of various factors on transfusion requirement and transfusion independence was assessed.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The median number of red blood cells transfusions was 2 (IQR 1–4), the median number of platelet transfusions was 5 (IQR 3–10). The only factor that influenced the volume of transfusion therapy was the type of diagnosis more transfusions were required for nonmalignant diseases. The duration of the transfusion-dependent period was influenced by the type of diagnosis, haematopoietic stem cell source and donor type. Gender differences between donor and recipient, as well as differences in ABO and conditioning regime did not influence either transfusion requirement or independence from transfusions.</p></sec><sec><title>Conclusion</title><p>Conclusion. This analysis presents the need for transfusions of donor blood components in allogeneic HSCT recipients during 1 year.</p><p>The results of the analysis can be used for planning the activities of transplantation centres and blood service institutions to provide transfusion support for HSCT recipients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансфузии</kwd><kwd>заготовка компонентов донорской крови</kwd><kwd>потребность в трансфузиях</kwd><kwd>аллогенная трансплантация гемопоэтических стволовых клеток</kwd></kwd-group><kwd-group xml:lang="en"><kwd>transfusions</kwd><kwd>donor blood components manufacturing</kwd><kwd>processing of donor blood components</kwd><kwd>calculation of transfusion requirements</kwd><kwd>allogeneic haematopoietic stem cell transplantation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проведено без спонсорской поддержки</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Milkins C., Berryman J., Cantwell C., Elliott C., Haggas R., Jones J., Rowley M., Williams M., Win N. Guidelines for pretrnafusion compatibility procedures in blood transfusion laboratories. Transfus Med. 2013;23:3–35. doi: 10.1111/j.1365-3148.2012.01199.x.</mixed-citation><mixed-citation xml:lang="en">Milkins C., Berryman J., Cantwell C., Elliott C., Haggas R., Jones J., Rowley M., Williams M., Win N. Guidelines for pretrnafusion compatibility procedures in blood transfusion laboratories. Transfus Med. 2013;23:3–35. doi: 10.1111/j.1365-3148.2012.01199.x.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Adkins B.D., Booth G.S., Vasu S. Transfusion support for stem cell transplant recipients. Semin Hematol. 2020;57:51–6. doi: 10.1053/j.seminhematol.2020.07.001.</mixed-citation><mixed-citation xml:lang="en">Adkins B.D., Booth G.S., Vasu S. Transfusion support for stem cell transplant recipients. Semin Hematol. 2020;57:51–6. doi: 10.1053/j.seminhematol.2020.07.001.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Morishima Y., Kashiwase K., Matsuo K., Azuma F., Morishima S., Onizuka M., Yabe T., Murata M., Doki N., Eto T., Mori T., Miyamura K., Sao H., Ichinohe T., Saji H., Kato S., Atsuta Y., Kawa K., Kodera Y., Sasazuki T.; Japan Marrow Donor Program. Biological significance of HLA locus matching in unrelated donor bone marrow transplantation. Blood. 2015;125:1189–97. doi: 10.1182/blood-2014-10-604785.</mixed-citation><mixed-citation xml:lang="en">Morishima Y., Kashiwase K., Matsuo K., Azuma F., Morishima S., Onizuka M., Yabe T., Murata M., Doki N., Eto T., Mori T., Miyamura K., Sao H., Ichinohe T., Saji H., Kato S., Atsuta Y., Kawa K., Kodera Y., Sasazuki T.; Japan Marrow Donor Program. Biological signifi cance of HLA locus matching in unrelated donor bone marrow transplantation. Blood. 2015;125:1189–97. doi: 10.1182/blood-2014-10-604785.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rowley S.D. Hematopoietic stem cell transplantation between red cell incompatible donor-recipient pairs. Bone Marrow Transplant. 2001;28(4):315–21. doi: 10.1038/sj.bmt.1703135. PMID: 11571501.</mixed-citation><mixed-citation xml:lang="en">Rowley S.D. Hematopoietic stem cell transplantation between red cell incompatible donor-recipient pairs. Bone Marrow Transplant. 2001;28(4):315–21. doi: 10.1038/sj.bmt.1703135. PMID: 11571501.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cohn C.S. Transfusion support issues in hematopoietic stem cell transplantation. Cancer Control. 2015;22(1):52–9. doi: 10.1177/107327481502200108. PMID: 25504279.</mixed-citation><mixed-citation xml:lang="en">Cohn C.S. Transfusion support issues in hematopoietic stem cell transplantation. Cancer Control. 2015;22(1):52–9. doi: 10.1177/107327481502200108. PMID: 25504279.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Warner M.A., Jambhekar N.S., Saadeh S., Jacob EK., Kreuter J.D., Mundell W.C., Marquez A., Higgins A.A., Madde N.R., Hogan W.J., Kor D.J. Implementation of a patient blood management program in hematopoietic stem cell transplantation. Transfusion. 2019;59:2840–8. doi: 10.1111/trf.15414.</mixed-citation><mixed-citation xml:lang="en">Warner M.A., Jambhekar N.S., Saadeh S., Jacob EK., Kreuter J.D., Mundell W.C., Marquez A., Higgins A.A., Madde N.R., Hogan W.J., Kor D.J. Implementation of a patient blood management program in hematopoietic stem cell transplantation. Transfusion. 2019;59:2840–8. doi: 10.1111/trf.15414.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Datta S.S., Basu S., Chandy M. An analysis of transfusion support in haematopoietic stem cell transplantation – report from a centre in India. Transfus Apher Sci. 2015;53(3):373–7. doi: 10.1016/j.transci.2015.07.006. Epub 2015 Aug 18. PMID: 26321099.</mixed-citation><mixed-citation xml:lang="en">Datta S.S., Basu S., Chandy M. An analysis of transfusion support in haematopoietic stem cell transplantation – report from a centre in India. Transfus Apher Sci. 2015;53(3):373–7. doi: 10.1016/j.transci.2015.07.006. Epub 2015 Aug 18. PMID: 26321099.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Griffith L.M., VanRaden M., Barrett A.J., Childs R.W., Fowler D.H., Kang E.M., Tisdale J.F., Klein H.G., Stroncek D.F. Transfusion support for matched sibling allogeneic hematopoietic stem cell transplantation (1993–2010): factors that predict intensity and time to transfusion independence. Transfusion. 2019;59(1):303–15. doi: 10.1111/trf.14966. Epub 2018 Oct 26. PMID: 30362577; PMCID: PMC6322947.</mixed-citation><mixed-citation xml:lang="en">Griffi th L.M., VanRaden M., Barrett A.J., Childs R.W., Fowler D.H., Kang E.M., Tisdale J.F., Klein H.G., Stroncek D.F. Transfusion support for matched sibling allogeneic hematopoietic stem cell transplantation (1993–2010): factors that predict intensity and time to transfusion independence. Transfusion. 2019;59(1):303–15. doi: 10.1111/trf.14966. Epub 2018 Oct 26. PMID: 30362577; PMCID: PMC6322947.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H., Ko D.H. Transfusion in ABO-incompatible solid organ transplantation. Korean J Blood Transfus. 2020;31:70–2. doi: 10.17945/kjbt.2020.31.1.7.</mixed-citation><mixed-citation xml:lang="en">Kim H., Ko D.H. Transfusion in ABO-incompatible solid organ transplantation. Korean J Blood Transfus. 2020;31:70–2. doi: 10.17945/kjbt.2020.31.1.7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gajewski J.L., Johnson V.V., Sandler S.G., Sayegh A., Klumpp T.R. A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation. Blood. 2008;112(8):3036–47. doi: 10.1182/blood-2007-10-118372. Epub 2008 Jun 26. PMID: 18583566; PMCID: PMC2569162.</mixed-citation><mixed-citation xml:lang="en">Gajewski J.L., Johnson V.V., Sandler S.G., Sayegh A., Klumpp T.R. A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation. Blood. 2008;112(8):3036–47. doi: 10.1182/blood-2007-10-118372. Epub 2008 Jun 26. PMID: 18583566; PMCID: PMC2569162.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Аксельрод Б.А., Балашова Е.Н., Баутин А.Е., Баховадинов Б.Б., Бирюкова Л.С., Буланов А.Ю., Быстрых О.А., Виноградова М.А., Галстян Г.М., Гапонова Т.В., Головкина Л.Л., Гороховский В.С., Еременко А.А., Жибурт Е.Б., Журавель С.В., Кохно А.В., Кузьмина Л.А., Кулабухов В.В., Купряшов А.А., Лубнин А.Ю., Мазурок В.А., Меньшугин И.Н., Минеева Н.В., Михайлова Е.А., Никитин Е.А., Оловникова Н.И., Ошоров А.В., Певцов Д.Э., Попцов В.Н., Рогачевский О.В., Салимов Э.Л., Титков К.В., Трахтман П.Е., Троицкая В.В., Федорова Т.А., Фидарова З.Т., Цветаева Н.В., Чжао А.В., Шестаков Е.Ф. Клиническое использование эритроцитсодержащих компонентов донорской крови. Гематология и трансфузиология. 2018;63(4):372–435. doi: 10.25837/HAT.2019.62.39.006.</mixed-citation><mixed-citation xml:lang="en">Akselrod B.A., Balashova E.N., Bautin A.E., Bakhovadinov B.B., Biryukova L.S., Bulanov A.Yu., Bystrykh O.A., Vinogradova M.A., Galstyan G.M., Gaponova T.V., Golovkina L.L., Gorokhovskiy V.S., Eremenko A.A., Zhiburt E.B., Zhuravel S.V., Kokhno A.V., Kuzmina L.A., Kulabukhov V.V., Kupryashov A.A., Lubnin A.Yu., Mazurok V.A., Menshugin I.N., Mineeva N.V., Mihailova E.A., Nikitin E.A., Olovnikova N.I., Oshorov A.V., Pevtsov D.E., Poptsov V.N., Rogachevskiy O.V., Salimov E.L., Titkov K.V., Trakhtman P.E., Troitskaya V.V., Fedorova T.A., Fidarova Z.T., Tsvetaeva N.V., Chzhao A.V., Shestakov E.F. Clinical guidelines for red blood cell transfusion. Gematologiya i transfuziologiya = Russian journal of hematology and transfusiology. 2018;63(4):372–435. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Балашов Д.Н., Трахтман П.Е. Особенности проведения трансфузионной терапии у пациентов после трансплантации гемопоэтических стволовых клеток. Обзор литературы. Онкогематология. 2013;8(3):42–7. doi: 10.17650/1818-8346-2013-8-3-42-47</mixed-citation><mixed-citation xml:lang="en">Balashov D.N., Trakhtman P.E. Features of transfusion therapy in patients undergoing hematopoietic stem cell transplantation. Review of the literature. Onkogematologiya = Oncohematology. 2013;8(3):42–7. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Z., Sorror M.L., Leisenring W., Schoch G., Maloney D.G., Sandmaier B.M., Storb R. The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation. Br J Haematol. 2010;149(1):101–10. doi: 10.1111/j.1365-2141.2009.08073.x. Epub 2010 Jan 11. PMID: 20067562; PMCID: PMC2864362.</mixed-citation><mixed-citation xml:lang="en">Wang Z., Sorror M.L., Leisenring W., Schoch G., Maloney D.G., Sandmaier B.M., Storb R. The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation. Br J Haematol. 2010;149(1):101–10. doi: 10.1111/j.1365-2141.2009.08073.x. Epub 2010 Jan 11. PMID: 20067562; PMCID: PMC2864362.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tay J., Allan D.S., Chatelain E., Coyle D., Elemary M., Fulford A., Petrcich W., Ramsay T., Walker I., Xenocostas A., Tinmouth A., Fergusson D. Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial. J Clin Oncol. 2020;38(13):1463–73. doi: 10.1200/JCO.19.01836. Epub 2020 Feb 21. PMID: 32083994.</mixed-citation><mixed-citation xml:lang="en">Tay J., Allan D.S., Chatelain E., Coyle D., Elemary M., Fulford A., Petrcich W., Ramsay T., Walker I., Xenocostas A., Tinmouth A., Fergusson D. Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial. J Clin Oncol. 2020;38(13):1463–73. doi: 10.1200/JCO.19.01836. Epub 2020 Feb 21. PMID: 32083994.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Robitaille N., Lacroix J., Alexandrov L., Clayton L., Cortier M., Schultz K.R., Bittencourt H., Duval M. Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trial. Biol Blood Marrow Transplant. 2013;19(3):468–73. doi: 10.1016/j.bbmt.2012.12.002. Epub 2012 Dec 7. PMID: 23220014.</mixed-citation><mixed-citation xml:lang="en">Robitaille N., Lacroix J., Alexandrov L., Clayton L., Cortier M., Schultz K.R., Bittencourt H., Duval M. Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trial. Biol Blood Marrow Transplant. 2013;19(3):468–73. doi: 10.1016/j.bbmt.2012.12.002. Epub 2012 Dec 7. PMID: 23220014.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hosoba S., Waller E.K., Shenvi N., Graiser M., Easley K.A., Al-Kadhimi Z., Andoh A., Antun A.G., Barclay S., Josephson C.D., Koff J. L., Jean Khoury H., Langston A.A., Zimring J.C., Roback J.D., Giver C.R. Peritransplantation red blood cell transfusion is associated with increased risk of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2018;24:973–82. doi: 10.1016/j.bbmt.2018.01.003.</mixed-citation><mixed-citation xml:lang="en">Hosoba S., Waller E.K., Shenvi N., Graiser M., Easley K.A., Al-Kadhimi Z., Andoh A., Antun A.G., Barclay S., Josephson C.D., Koff J. L., Jean Khoury H., Langston A.A., Zimring J.C., Roback J.D., Giver C.R. Peritransplantation red blood cell transfusion is associated with increased risk of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2018;24:973–82. doi: 10.1016/j.bbmt.2018.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schrezenmeier H., Körper S., Höchsmann B., Weinstock C., Carreras E., Dufour C., Mohty M., Kröger N., eds. Transfusion support. In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. 7th ed. Cham (CH): Springer, 2019. Chapter 23. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553976/. doi: 10.1007/978-3-030-02278-5_23.</mixed-citation><mixed-citation xml:lang="en">Schrezenmeier H., Körper S., Höchsmann B., Weinstock C., Carreras E., Dufour C., Mohty M., Kröger N., eds. Transfusion support. In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. 7th ed. Cham (CH): Springer, 2019. Chapter 23. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553976/. doi: 10.1007/978-3-030-02278-5_23.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jekarl D.W., Kim J.K., Han J.H., Lee H., Yoo J., Lim J., Kim Y. Transfusion support in hematopoietic stem cell transplantation. Blood Res. 2023;58(S1):S1–7. doi: 10.5045/br.2023.2023004. Epub 2023 Feb 27. PMID: 36843378; PMCID: PMC10133853.</mixed-citation><mixed-citation xml:lang="en">Jekarl D.W., Kim J.K., Han J.H., Lee H., Yoo J., Lim J., Kim Y. Transfusion support in hematopoietic stem cell transplantation. Blood Res. 2023;58(S1):S1–7. doi: 10.5045/br.2023.2023004. Epub 2023 Feb 27. PMID: 36843378; PMCID: PMC10133853.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Fung M., Eder A.F., Spitalnik S.L., Westhoff C.M. Technical manual. 19th ed. Bethesda, MD: AABB Press, 2017. Pp. 683–91.</mixed-citation><mixed-citation xml:lang="en">Fung M., Eder A.F., Spitalnik S.L., Westhoff C.M. Technical manual. 19th ed. Bethesda, MD: AABB Press, 2017. Pp. 683–91.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Woo K.S., Kim J.E., Kim K.E., Kim J.M., Han J.Y., Kim S.H., Kim K.H. Effect of ABO-incompatibility on allogeneic hematopoietic stem cell transplantation. A single institute study. Korean J Blood Transfus. 2009;20:235–41. doi: 10.32388/uqy1gr.</mixed-citation><mixed-citation xml:lang="en">Woo K.S., Kim J.E., Kim K.E., Kim J.M., Han J.Y., Kim S.H., Kim K.H. Eff ect of ABO-incompatibility on allogeneic hematopoietic stem cell transplantation. A single institute study. Korean J Blood Transfus. 2009;20:235–41. doi: 10.32388/uqy1gr.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Solves P., Carpio N., Carretero C., Lorenzo J.I., Sanz J., Gómez I., López-Chuliá F., Arilla M.J., Regadera A.I., Montesinos P., Sanz G.F., Sanz M.Á. ABO incompatibility does not infl uence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation. Bone Marrow Transplant. 2017;52(3):394–9. doi: 10.1038/bmt.2016.264. Epub 2016 Oct 31. PMID: 27797368.</mixed-citation><mixed-citation xml:lang="en">Solves P., Carpio N., Carretero C., Lorenzo J.I., Sanz J., Gómez I., López-Chuliá F., Arilla M.J., Regadera A.I., Montesinos P., Sanz G.F., Sanz M.Á. ABO incompatibility does not infl uence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation. Bone Marrow Transplant. 2017;52(3):394–9. doi: 10.1038/bmt.2016.264. Epub 2016 Oct 31. PMID: 27797368.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ojha S., Patle V., Nagaraju P., Khattry N. Blood components utilization in hematopoietic stem cell transplantation: Thirteen-year analysis from an apex oncology center of India. Asian J Transfus Sci. 2023;17(2):221–8. doi: 10.4103/ajts.ajts_12_22.</mixed-citation><mixed-citation xml:lang="en">Ojha S., Patle V., Nagaraju P., Khattry N. Blood components utilization in hematopoietic stem cell transplantation: Thirteen-year analysis from an apex oncology center of India. Asian J Transfus Sci. 2023;17(2):221–8. doi: 10.4103/ajts.ajts_12_22.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan S., Yang D., Nakamura R., Zhuang L., Al Malki M.M., Wang S. RBC and platelet transfusion support in the first 30 and 100 days after haploidentical hematopoietic stem cell transplantation. Transfusion. 2019;59(11):3371–85. doi: 10.1111/trf.15531. Epub 2019 Oct 10. PMID: 31599972.</mixed-citation><mixed-citation xml:lang="en">Yuan S., Yang D., Nakamura R., Zhuang L., Al Malki M.M., Wang S. RBC and platelet transfusion support in the fi rst 30 and 100 days after haploidentical hematopoietic stem cell transplantation. Transfusion. 2019;59(11):3371–85. doi: 10.1111/trf.15531. Epub 2019 Oct 10. PMID: 31599972.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Weissinger F., Sandmaier B.M., Maloney D.G., Bensinger W.I., Gooley T., Storb R. Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings. Blood. 2001;98(13):3584–8. doi: 10.1182/blood.v98.13.3584. PMID: 11739160.</mixed-citation><mixed-citation xml:lang="en">Weissinger F., Sandmaier B.M., Maloney D.G., Bensinger W.I., Gooley T., Storb R. Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings. Blood. 2001;98(13):3584–8. doi: 10.1182/blood.v98.13.3584. PMID: 11739160.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanov V., Faucher C., Mohty M., Bilger K., Ladaique P., Sainty D., Arnoulet C., Chabannon C., Vey N., Camerlo J., Bouabdallah R., Maraninchi D., Bardou V.J., Blaise D. Decreased RBCTs after reduced intensity conditioning allogeneic stem cell transplantation: predictive value of prior Hb level. Transfusion. 2004;44(4):501–8. doi: 10.1111/j.1537-2995.2004.03317.x. PMID: 15043564.</mixed-citation><mixed-citation xml:lang="en">Ivanov V., Faucher C., Mohty M., Bilger K., Ladaique P., Sainty D., Arnoulet C., Chabannon C., Vey N., Camerlo J., Bouabdallah R., Maraninchi D., Bardou V.J., Blaise D. Decreased RBCTs after reduced intensity conditioning allogeneic stem cell transplantation: predictive value of prior Hb level. Transfusion. 2004;44(4):501–8. doi: 10.1111/j.1537-2995.2004.03317.x. PMID: 15043564.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Liesveld J., Pawlowski J., Chen R., Hyrien O., Debolt J., Becker M., Phillips G. 2nd, Chen Y. Clinical factors aff ecting engraftment and transfusion needs in SCT: a single-center retrospective analysis. Bone Marrow Transplant. 2013;48(5):691–7. doi: 10.1038/bmt.2012.194. Epub 2012 Oct 22. PMID: 23085827.</mixed-citation><mixed-citation xml:lang="en">Liesveld J., Pawlowski J., Chen R., Hyrien O., Debolt J., Becker M., Phillips G. 2nd, Chen Y. Clinical factors aff ecting engraftment and transfusion needs in SCT: a single-center retrospective analysis. Bone Marrow Transplant. 2013;48(5):691–7. doi: 10.1038/bmt.2012.194. Epub 2012 Oct 22. PMID: 23085827.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
