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<article article-type="conference-paper" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nodgo-1257</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКИЕ ВОПРОСЫ ДЕТСКОЙ ОНКОЛОГИИ-ГЕМАТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL QUESTIONS OF PEDIATRIC ONCOLOGY-HEMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Актуальные вопросы применения блинатумомаба у детей с острыми лейкозами. Обзор по материалам сателлитного симпозиума «Лечение лейкозов. Вчера, сегодня, завтра»</article-title><trans-title-group xml:lang="en"><trans-title>Current issues regarding the use of blinatumomab in children with acute leukemia. Review of materials from the satellite symposium “Treatment of Leukemia: Yesterday, Today, Tomorrow”</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурцев</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Burtsev</surname><given-names>E. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цветкова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsvetkova</surname><given-names>L. A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киргизов</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirgizov</surname><given-names>K. I.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2026</year></pub-date><volume>13</volume><issue>1</issue><fpage>112</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бурцев Е.А., Цветкова Л.А., Киргизов К.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Бурцев Е.А., Цветкова Л.А., Киргизов К.И.</copyright-holder><copyright-holder xml:lang="en">Burtsev E.A., Tsvetkova L.A., Kirgizov K.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/1257">https://journal.nodgo.org/jour/article/view/1257</self-uri><abstract><p>.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hunger S.P., Mullighan C.G. Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2015;373(16):1541–52. doi: 10.1056/NEJMra1400972.</mixed-citation><mixed-citation xml:lang="en">Hunger S.P., Mullighan C.G. Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2015;373(16):1541–52. doi: 10.1056/NEJMra1400972.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tallen G., Ratei R., Mann G., Kaspers G., Niggli F., Karachunsky A., Ebell W., Escherich G., Schrappe M., Klingebiel T., Fengler R., Henze G., von Stackelberg A. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J Clin Oncol. 2010;28(14):2339–47. doi: 10.1200/JCO.2009.25.1983.</mixed-citation><mixed-citation xml:lang="en">Tallen G., Ratei R., Mann G., Kaspers G., Niggli F., Karachunsky A., Ebell W., Escherich G., Schrappe M., Klingebiel T., Fengler R., Henze G., von Stackelberg A. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratifi cation and intensifi ed short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J Clin Oncol. 2010;28(14):2339–47. doi: 10.1200/JCO.2009.25.1983.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">von Stackelberg A., Völzke E., Kühl J.S., Seeger K., Schrauder A., Escherich G., Henze G., Tallen G.; ALL-REZ BFM Study Group. Outcome of children and adolescents with relapsed acute lymphoblastic leukaemia and non-response to salvage protocol therapy: a retrospective analysis of the ALL-REZ BFM Study Group. Eur J Cancer. 2011;47(1):90–7. doi: 10.1016/j.ejca.2010.09.020.</mixed-citation><mixed-citation xml:lang="en">von Stackelberg A., Völzke E., Kühl J.S., Seeger K., Schrauder A., Escherich G., Henze G., Tallen G.; ALL-REZ BFM Study Group. Outcome of children and adolescents with relapsed acute lymphoblastic leukaemia and non-response to salvage protocol therapy: a retrospective analysis of the ALL-REZ BFM Study Group. Eur J Cancer. 2011;47(1):90–7. doi: 10.1016/j.ejca.2010.09.020.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rabinovich G.A., Gabrilovich D., Sotomayor E.M. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 2007;25:267–96. doi: 10.1146/annurev.immunol.25.022106.141609.</mixed-citation><mixed-citation xml:lang="en">Rabinovich G.A., Gabrilovich D., Sotomayor E.M. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 2007;25:267–96. doi: 10.1146/annurev.immunol.25.022106.141609.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Baeuerle P.A., Reinhardt C. Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res. 2009;69(12):4941–4. doi: 10.1158/0008-5472.CAN-09-0547.</mixed-citation><mixed-citation xml:lang="en">Baeuerle P.A., Reinhardt C. Bispecifi c T-cell engaging antibodies for cancer therapy. Cancer Res. 2009;69(12):4941–4. doi: 10.1158/0008-5472.CAN-09-0547.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bargou R., Leo E., Zugmaier G., Klinger M., Goebeler M., Knop S., Noppeney R., Viardot A., Hess G., Schuler M., Einsele H., Brandl C., Wolf A., Kirchinger P., Klappers P., Schmidt M., Riethmüller G., Reinhardt C., Baeuerle P.A., Kufer P. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321(5891):974–7. doi: 10.1126/science.1158545.</mixed-citation><mixed-citation xml:lang="en">Bargou R., Leo E., Zugmaier G., Klinger M., Goebeler M., Knop S., Noppeney R., Viardot A., Hess G., Schuler M., Einsele H., Brandl C., Wolf A., Kirchinger P., Klappers P., Schmidt M., Riethmüller G., Reinhardt C., Baeuerle P.A., Kufer P. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321(5891):974–7. doi: 10.1126/science.1158545.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Topp M.S., Gökbuget N., Zugmaier G., Klappers P., Stelljes M., Neumann S., Viardot A., Marks R., Diedrich H., Faul C., Reichle A., Horst H.A., Brüggemann M., Wessiepe D., Holland C., Alekar S., Mergen N., Einsele H., Hoelzer D., Bargou R.C. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol. 2014;32(36):4134–40. doi: 10.1200/JCO.2014.56.3247.</mixed-citation><mixed-citation xml:lang="en">Topp M.S., Gökbuget N., Zugmaier G., Klappers P., Stelljes M., Neumann S., Viardot A., Marks R., Diedrich H., Faul C., Reichle A., Horst H.A., Brüggemann M., Wessiepe D., Holland C., Alekar S., Mergen N., Einsele H., Hoelzer D., Bargou R.C. Phase II trial of the anti-CD19 bispecifi c T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol. 2014;32(36):4134–40. doi: 10.1200/JCO.2014.56.3247.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">von Stackelberg A., Locatelli F., Zugmaier G., Handgretinger R., Trippett T.M., Rizzari C., Bader P., OʼBrien M.M., Brethon B., Bhojwani D., Schlegel P.G., Borkhardt A., Rheingold S.R., Cooper T.M., Zwaan C.M., Barnette P., Messina C., Michel G., DuBois S.G., Hu K., Zhu M., Whitlock J.A., Gore L. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/ Refractory Acute Lymphoblastic Leukemia. J Clin Oncol. 2016;34(36):4381–9. doi: 10.1200/JCO.2016.67.3301.</mixed-citation><mixed-citation xml:lang="en">von Stackelberg A., Locatelli F., Zugmaier G., Handgretinger R., Trippett T.M., Rizzari C., Bader P., OʼBrien M.M., Brethon B., Bhojwani D., Schlegel P.G., Borkhardt A., Rheingold S.R., Cooper T.M., Zwaan C.M., Barnette P., Messina C., Michel G., DuBois S.G., Hu K., Zhu M., Whitlock J.A., Gore L. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/ Refractory Acute Lymphoblastic Leukemia. J Clin Oncol. 2016;34(36):4381–9. doi: 10.1200/JCO.2016.67.3301.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F., Zugmaier G., Mergen N., Bader P., Jeha S., Schlegel P.G., Bourquin J.P., Handgretinger R., Brethon B., Rossig C., Chen-Santel C. Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study. Blood Cancer J. 2020;10(7):77. doi: 10.1038/s41408-020-00342-x. Erratum in: Blood Cancer J. 2021;11(2):28. doi: 10.1038/s41408-021-00413-7. Erratum in: Blood Cancer J. 2021;11(10):173. doi: 10.1038/s41408-021-00567-4.</mixed-citation><mixed-citation xml:lang="en">Locatelli F., Zugmaier G., Mergen N., Bader P., Jeha S., Schlegel P.G., Bourquin J.P., Handgretinger R., Brethon B., Rossig C., Chen-Santel C. Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study. Blood Cancer J. 2020;10(7):77. doi: 10.1038/s41408-020-00342-x. Erratum in: Blood Cancer J. 2021;11(2):28. doi: 10.1038/s41408-021-00413-7. Erratum in: Blood Cancer J. 2021;11(10):173. doi: 10.1038/s41408-021-00567-4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F., Zugmaier G., Rizzari C., Morris J.D., Gruhn B., Klingebiel T., Parasole R., Linderkamp C., Flotho C., Petit A., Micalizzi C., Mergen N., Mohammad A., Kormany W.N., Eckert C., Möricke A., Sartor M., Hrusak O., Peters C., Saha V., Vinti L., von Stackelberg A. Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2021;325(9):843–54. doi: 10.1001/jama.2021.0987.</mixed-citation><mixed-citation xml:lang="en">Locatelli F., Zugmaier G., Rizzari C., Morris J.D., Gruhn B., Klingebiel T., Parasole R., Linderkamp C., Flotho C., Petit A., Micalizzi C., Mergen N., Mohammad A., Kormany W.N., Eckert C., Möricke A., Sartor M., Hrusak O., Peters C., Saha V., Vinti L., von Stackelberg A. Eff ect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2021;325(9):843–54. doi: 10.1001/jama.2021.0987.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">DiNardo C.D., Konopleva M.Y. A venetoclax bench-to-bedside story. Nat Cancer. 2021;2(1):3–5. doi: 10.1038/s43018-020-00165-6.</mixed-citation><mixed-citation xml:lang="en">DiNardo C.D., Konopleva M.Y. A venetoclax bench-to-bedside story. Nat Cancer. 2021;2(1):3–5. doi: 10.1038/s43018-020-00165-6.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">DiNardo C.D., Pratz K., Pullarkat V., Jonas B.A., Arellano M., Becker P.S., Frankfurt O., Konopleva M., Wei A.H., Kantarjian H.M., Xu T., Hong W.J., Chyla B., Potluri J., Pollyea D.A., Letai A. Venetoclax combined with decitabine or azacitidine in treatmentnaive, elderly patients with acute myeloid leukemia. Blood. 2019;133(1):7–17. doi: 10.1182/blood-2018-08-868752.</mixed-citation><mixed-citation xml:lang="en">DiNardo C.D., Pratz K., Pullarkat V., Jonas B.A., Arellano M., Becker P.S., Frankfurt O., Konopleva M., Wei A.H., Kantarjian H.M., Xu T., Hong W.J., Chyla B., Potluri J., Pollyea D.A., Letai A. Venetoclax combined with decitabine or azacitidine in treatmentnaive, elderly patients with acute myeloid leukemia. Blood. 2019;133(1):7–17. doi: 10.1182/blood-2018-08-868752.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Karol S.E., Alexander T.B., Budhraja A., Pounds S.B., Canavera K., Wang L., Wolf J., Klco J.M., Mead P.E., Das Gupta S., Kim S.Y., Salem A.H., Palenski T., Lacayo N.J., Pui C.H., Opferman J.T., Rubnitz J.E. Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. Lancet Oncol. 2020;21(4):551–60. doi: 10.1016/S1470-2045(20)30060-7.</mixed-citation><mixed-citation xml:lang="en">Karol S.E., Alexander T.B., Budhraja A., Pounds S.B., Canavera K., Wang L., Wolf J., Klco J.M., Mead P.E., Das Gupta S., Kim S.Y., Salem A.H., Palenski T., Lacayo N.J., Pui C.H., Opferman J.T., Rubnitz J.E. Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. Lancet Oncol. 2020;21(4):551–60. doi: 10.1016/S1470-2045(20)30060-7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Winters A.C., Maloney K.W., Treece A.L., Gore L., Franklin A.K. Single-center pediatric experience with venetoclax and azacitidine as treatment for myelodysplastic syndrome and acute myeloid leukemia. Pediatr Blood Cancer. 2020;67(10):e28398. doi: 10.1002/pbc.28398.</mixed-citation><mixed-citation xml:lang="en">Winters A.C., Maloney K.W., Treece A.L., Gore L., Franklin A.K. Single-center pediatric experience with venetoclax and azacitidine as treatment for myelodysplastic syndrome and acute myeloid leukemia. Pediatr Blood Cancer. 2020;67(10):e28398. doi: 10.1002/pbc.28398.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bobeff K., Pastorczak A., Urbanska Z., Balwierz W., Juraszewska E., Wachowiak J., Derwich K., Samborska M., Kalwak K., Dachowska- Kalwak I., Laguna P., Malinowska I., Smalisz K., Gozdzik J., Oszer A., Urbanski B., Zdunek M., Szczepanski T., Mlynarski W., Janczar S. Venetoclax use in paediatric haemato-oncology centres in Poland: a 2022 survey. Children (Basel). 2023;10(4):745. doi: 10.3390/children10040745.</mixed-citation><mixed-citation xml:lang="en">Bobeff  K., Pastorczak A., Urbanska Z., Balwierz W., Juraszewska E., Wachowiak J., Derwich K., Samborska M., Kalwak K., Dachowska- Kalwak I., Laguna P., Malinowska I., Smalisz K., Gozdzik J., Oszer A., Urbanski B., Zdunek M., Szczepanski T., Mlynarski W., Janczar S. Venetoclax use in paediatric haemato-oncology centres in Poland: a 2022 survey. Children (Basel). 2023;10(4):745. doi: 10.3390/children10040745.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Pfeiffer T., Li Y., Karol S.E. Venetoclax-based combination therapy as a bridge to allogeneic hematopoietic stem cell transplant in children with relapsed/refractory AML. Transplant Cell Ther. 2022;28(3):S120–S121.</mixed-citation><mixed-citation xml:lang="en">Pfeiff er T., Li Y., Karol S.E. Venetoclax-based combination therapy as a bridge to allogeneic hematopoietic stem cell transplant in children with relapsed/refractory AML. Transplant Cell Ther. 2022;28(3):S120–S121.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Place A.E., Karol S.E., Forlenza C.J., Cooper T.M., Fraser C., Cario G., OʼBrien M.M., Gerber N.U., Bourquin J.P., Reinhardt D., Rubnitz J.E., Opferman J.T., Sunkersett G., Onishi M., Dunshee D.R., Chen X., Unnebrink K., Vishwamitra D., Dunbar F., Badawi M., Ross J.A., Loh M.L. Venetoclax Combined With Chemotherapy in Pediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2025;72(6):e31630. doi: 10.1002/pbc.31630.</mixed-citation><mixed-citation xml:lang="en">Place A.E., Karol S.E., Forlenza C.J., Cooper T.M., Fraser C., Cario G., OʼBrien M.M., Gerber N.U., Bourquin J.P., Reinhardt D., Rubnitz J.E., Opferman J.T., Sunkersett G., Onishi M., Dunshee D.R., Chen X., Unnebrink K., Vishwamitra D., Dunbar F., Badawi M., Ross J.A., Loh M.L. Venetoclax Combined With Chemotherapy in Pediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2025;72(6):e31630. doi: 10.1002/pbc.31630.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ma J., Luong A., Doan A., Lin T.Y., Ji L., Wang C.P., Yoon S.J., Rushing T., Duong A., Villa M., Parekh C. T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia. Blood Adv. 2025;9(15):3689–93. doi: 10.1182/bloodadvances.2025015894.</mixed-citation><mixed-citation xml:lang="en">Ma J., Luong A., Doan A., Lin T.Y., Ji L., Wang C.P., Yoon S.J., Rushing T., Duong A., Villa M., Parekh C. T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia. Blood Adv. 2025;9(15):3689–93. doi: 10.1182/bloodadvances.2025015894.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Глуханюк Е.В., Степанов А.В., Попов А.М., Масчан М.А. Механизмы резистентности В-линейного острого лимфобластного лейкоза при применении CD19-направленной иммунотерапии. Онкогематология. 2018;13(4):27–36. doi: 10.17650/1818-8346-2019- 13-4-27-36.</mixed-citation><mixed-citation xml:lang="en">Glukhanyuk E.V., Stepanov A.V., Popov A.M., Maschan M.A. CD-19-directed immunotherapy resistance mechanisms of B-precursor acute lymphoblastic leukemia. Oncohematology. 2018;13(4):27–36. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sotillo E., Barrett D.M., Black K.L., Bagashev A., Oldridge D., Wu G., Sussman R., Lanauze C., Ruella M., Gazzara M.R., Martinez N.M., Harrington C.T., Chung E.Y., Perazzelli J., Hofmann T.J., Maude S.L., Raman P., Barrera A., Gill S., Lacey S.F., Melenhorst J.J., Allman D., Jacoby E., Fry T., Mackall C., Barash Y., Lynch K.W., Maris J.M., Grupp S.A., Thomas-Tikhonenko A. Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy. Cancer Discov. 2015;5(12):1282–95. doi: 10.1158/2159-8290.CD-15-1020.</mixed-citation><mixed-citation xml:lang="en">Sotillo E., Barrett D.M., Black K.L., Bagashev A., Oldridge D., Wu G., Sussman R., Lanauze C., Ruella M., Gazzara M.R., Martinez N.M., Harrington C.T., Chung E.Y., Perazzelli J., Hofmann T.J., Maude S.L., Raman P., Barrera A., Gill S., Lacey S.F., Melenhorst J.J., Allman D., Jacoby E., Fry T., Mackall C., Barash Y., Lynch K.W., Maris J.M., Grupp S.A., Thomas-Tikhonenko A. Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy. Cancer Discov. 2015;5(12):1282–95. doi: 10.1158/2159-8290.CD-15-1020.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Braig F., Brandt A., Goebeler M., Tony H.P., Kurze A.K., Nollau P., Bumm T., Böttcher S., Bargou R.C., Binder M. Resistance to antiCD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking. Blood. 2017;129(1):100–4. doi: 10.1182/blood-2016-05-718395.</mixed-citation><mixed-citation xml:lang="en">Braig F., Brandt A., Goebeler M., Tony H.P., Kurze A.K., Nollau P., Bumm T., Böttcher S., Bargou R.C., Binder M. Resistance to antiCD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane traffi  cking. Blood. 2017;129(1):100–4. doi: 10.1182/blood-2016-05-718395.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Susa K.J., Seegar T.C., Blacklow S.C., Kruse A.C. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020;9:e52337. doi: 10.7554/eLife.52337.</mixed-citation><mixed-citation xml:lang="en">Susa K.J., Seegar T.C., Blacklow S.C., Kruse A.C. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor traffi  cking. Elife. 2020;9:e52337. doi: 10.7554/eLife.52337.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Зеркаленкова Е.А., Илларионова О.И., Казакова А.Н., Пономарева Н.И., Байдун Л.В., Осипова Е.Ю., Дубровина М.Э., Попов А.М., Конюхова Т.В., Плясунова С.А., Мякова Н.В., Масчан А.А., Ольшанская Ю.В. Смена линейной дифференцировки в рецидиве острого лейкоза с перестройкой гена MLL (KMT2A). Обзор литературы и описание случаев. Онкогематология. 2016;11(2):21–9. doi: 10.17650/1818-8346-2016-11-2-21-29.</mixed-citation><mixed-citation xml:lang="en">Zerkalenkova E.A., Illarionova O.I., Kazakova A.N., Ponomareva N.I., Baydun L.V., Osipova E.Y., Dubrovina M.E., Popov A.M., Konyukhova T.V., Plyasunova S.A., Myakova N.V., Maschan A.A., Olshanskaya Y.V. Lineage switch in relapse of acute leukemia with rearrangement of MLL gene (KMT2A). literature review and case reports. Oncohematology. 2016;11(2):21–9. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rayes A., McMasters R.L., OʼBrien M.M. Lineage Switch in MLL-Rearranged Infant Leukemia Following CD19-Directed Therapy. Pediatr Blood Cancer. 2016;63(6):1113–5. doi: 10.1002/pbc.25953.</mixed-citation><mixed-citation xml:lang="en">Rayes A., McMasters R.L., OʼBrien M.M. Lineage Switch in MLL-Rearranged Infant Leukemia Following CD19-Directed Therapy. Pediatr Blood Cancer. 2016;63(6):1113–5. doi: 10.1002/pbc.25953.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Глуханюк Е.В., Илларионова О.И., Кашпор С.A., Плясунова С.A., Мякова Н.В., Масчан А.А., Попов А.M. Изменение экспрессии CD19 опухолевыми клетками при применении блинатумомаба у детей с рецидивами и рефрактерным течением В-линейного острого лимфобластного лейкоза. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2017;16(4):21–6. doi: 10.24287/1726-1708-2017-16-4-21-26.</mixed-citation><mixed-citation xml:lang="en">Gluhanyuk E.V., Illarionova O.I., Kashpor S.A., Plyasunova S.A., Miakova N.V., Maschan A.A., Popov A.M. Changes in CD19 expression after blinatumomab treatment in pediatric patients with relapsed/refractory B-lineage acute lymphoblastic leukemia. Pediatric Hematology/ Oncology and Immunopathology. 2017;16(4):21–6. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gardner R., Wu D., Cherian S., Fang M., Hanafi L.A., Finney O., Smithers H., Jensen M.C., Riddell S.R., Maloney D.G., Turtle C.J. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. Blood. 2016;127(20):2406–10. doi: 10.1182/blood-2015-08-665547.</mixed-citation><mixed-citation xml:lang="en">Gardner R., Wu D., Cherian S., Fang M., Hanafi  L.A., Finney O., Smithers H., Jensen M.C., Riddell S.R., Maloney D.G., Turtle C.J. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. Blood. 2016;127(20):2406–10. doi: 10.1182/blood-2015-08-665547.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Köhnke T., Krupka C., Tischer J., Knösel T., Subklewe M. Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab. J Hematol Oncol. 2015;8:111. doi: 10.1186/s13045-015-0213-6.</mixed-citation><mixed-citation xml:lang="en">Köhnke T., Krupka C., Tischer J., Knösel T., Subklewe M. Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecifi c T cell engager antibody blinatumomab. J Hematol Oncol. 2015;8:111. doi: 10.1186/s13045-015-0213-6.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Саяпина М.С. Иммунорегуляторные функции ингибиторов PD-1/ PD-L1 и развитие к ним резистентности. Злокачественные опухоли. 2017;(2):94–9. doi: 10.18027/2224-5057-2017-2-94-99.</mixed-citation><mixed-citation xml:lang="en">Sayapina M.S. Immunoregulatory functions of PD-1/PD-L1 inhibitors and development of resistance to them. Malignant tumours. 2017;(2):94–9. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wunderlich M., Manning N., Sexton C., OʼBrien E., Byerly L., Stillwell C., Perentesis J.P., Mulloy J.C., Mizukawa B. PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2021;11:642466. doi: 10.3389/fonc.2021.642466.</mixed-citation><mixed-citation xml:lang="en">Wunderlich M., Manning N., Sexton C., OʼBrien E., Byerly L., Stillwell C., Perentesis J.P., Mulloy J.C., Mizukawa B. PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2021;11:642466. doi: 10.3389/fonc.2021.642466.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang N., Hu W., Dai Y., Wang J., Qu L., Wang D., Liu B., Shao J., Shen S., Jiang H. Blinatumomab demonstrates MRD eradication in MRD-positive/chemotherapy-delayed pediatric B-ALL and high response in relapsed/refractory cases: a multicenter cohort study. Front Immunol. 2025;16:1607138. doi: 10.3389/fimmu.2025.1607138.</mixed-citation><mixed-citation xml:lang="en">Zhang N., Hu W., Dai Y., Wang J., Qu L., Wang D., Liu B., Shao J., Shen S., Jiang H. Blinatumomab demonstrates MRD eradication in MRD-positive/chemotherapy-delayed pediatric B-ALL and high response in relapsed/refractory cases: a multicenter cohort study. Front Immunol. 2025;16:1607138. doi: 10.3389/fi mmu.2025.1607138.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Duell J., Dittrich M., Bedke T., Mueller T., Eisele F., Rosenwald A., Rasche L., Hartmann E., Dandekar T., Einsele H., Topp M.S. Frequency of regulatory T cells determines the outcome of the T-cellengaging antibody blinatumomab in patients with B-precursor ALL. Leukemia. 2017;31(10):2181–90. doi: 10.1038/leu.2017.41.</mixed-citation><mixed-citation xml:lang="en">Duell J., Dittrich M., Bedke T., Mueller T., Eisele F., Rosenwald A., Rasche L., Hartmann E., Dandekar T., Einsele H., Topp M.S. Frequency of regulatory T cells determines the outcome of the T-cellengaging antibody blinatumomab in patients with B-precursor ALL. Leukemia. 2017;31(10):2181–90. doi: 10.1038/leu.2017.41.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng Y., Liu A. Blinatumomab in pediatric B-acute lymphoblastic leukemia. Front Immunol. 2025;16:1611701. doi: 10.3389/fimmu.2025.1611701.</mixed-citation><mixed-citation xml:lang="en">Cheng Y., Liu A. Blinatumomab in pediatric B-acute lymphoblastic leukemia. Front Immunol. 2025;16:1611701. doi: 10.3389/fimmu.2025.1611701.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Webster J., Luskin M., Prince G., Dezern A., DeAngelo D., Levis M., Blackford A., Sharon E., Streicher H., Luznik L., Gojo I. Blinatumomab in Combination with Immune Checkpoint Inhibitors of PD-1 and CTLA-4 in Adult Patients with Relapsed/Refractory (R/R) CD19 Positive B-Cell Acute Lymphoblastic Leukemia (ALL): Preliminary Results of a Phase I Study. Blood. 2018;132:557. doi: 10.1182/blood-2018-99-111845.</mixed-citation><mixed-citation xml:lang="en">Webster J., Luskin M., Prince G., Dezern A., DeAngelo D., Levis M., Blackford A., Sharon E., Streicher H., Luznik L., Gojo I. Blinatumomab in Combination with Immune Checkpoint Inhibitors of PD-1 and CTLA-4 in Adult Patients with Relapsed/Refractory (R/R) CD19 Positive B-Cell Acute Lymphoblastic Leukemia (ALL): Preliminary Results of a Phase I Study. Blood. 2018;132:557. doi: 10.1182/blood-2018-99-111845.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Stolz S.M., Hofer K.D., Rösler W., Deuel J., Schwotzer R., Schneidawind C., Schneidawind D., Manz M.G., Rieger M.J. Tyrosine kinase inhibitors with blinatumomab versus chemotherapy in Philadelphia-positive acute B-lymphoblastic leukemia. Int J Cancer. 2025;157(6):1197–204. doi: 10.1002/ijc.35468.</mixed-citation><mixed-citation xml:lang="en">Stolz S.M., Hofer K.D., Rösler W., Deuel J., Schwotzer R., Schneidawind C., Schneidawind D., Manz M.G., Rieger M.J. Tyrosine kinase inhibitors with blinatumomab versus chemotherapy in Philadelphia-positive acute B-lymphoblastic leukemia. Int J Cancer. 2025;157(6):1197–204. doi: 10.1002/ijc.35468.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kong J., Miao W., Lu J., Liu Y., Kong X., Qiu H., Song B. Shorter Duration of Blinatumomab Administration to 14 Days Has Same Efficacy and Safety Profile in Treatment of Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: A Retrospective Single-Center Study. Acta Haematol. 2025;148(4):437–42. doi: 10.1159/000542060.</mixed-citation><mixed-citation xml:lang="en">Kong J., Miao W., Lu J., Liu Y., Kong X., Qiu H., Song B. Shorter Duration of Blinatumomab Administration to 14 Days Has Same Effi  cacy and Safety Profi le in Treatment of Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: A Retrospective Single-Center Study. Acta Haematol. 2025;148(4):437–42. doi: 10.1159/000542060.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hall A.G., Rau R.E. Blinatumomab use in pediatric B-ALL: where are we now? Blood Adv. 2025;9(15):3946–54. doi: 10.1182/bloodadvances.2024014043.</mixed-citation><mixed-citation xml:lang="en">Hall A.G., Rau R.E. Blinatumomab use in pediatric B-ALL: where are we now? Blood Adv. 2025;9(15):3946–54. doi: 10.1182/bloodadvances.2024014043.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Handgretinger R., Zugmaier G., Henze G., Kreyenberg H., Lang P., von Stackelberg A. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia. 2011;25(1):181–4. doi: 10.1038/leu.2010.239.</mixed-citation><mixed-citation xml:lang="en">Handgretinger R., Zugmaier G., Henze G., Kreyenberg H., Lang P., von Stackelberg A. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia. 2011;25(1):181–4. doi: 10.1038/leu.2010.239.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F., Zugmaier G., Mergen N., Bader P., Jeha S., Schlegel P.G., Bourquin J.P., Handgretinger R., Brethon B., Rössig C., Kormany W.N., Viswagnachar P., Chen-Santel C. Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis. Blood Adv. 2022;6(3):1004–14. doi: 10.1182/bloodadvances.2021005579.</mixed-citation><mixed-citation xml:lang="en">Locatelli F., Zugmaier G., Mergen N., Bader P., Jeha S., Schlegel P.G., Bourquin J.P., Handgretinger R., Brethon B., Rössig C., Kormany W.N., Viswagnachar P., Chen-Santel C. Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study fi nal analysis. Blood Adv. 2022;6(3):1004–14. doi: 10.1182/bloodadvances.2021005579.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hogan L.E., Brown P.A., Ji L., Xu X., Devidas M., Bhatla T., Borowitz M.J., Raetz E.A., Carroll A., Heerema N.A., Zugmaier G., Sharon E., Bernhardt M.B., Terezakis S.A., Gore L., Whitlock J.A., Hunger S.P., Loh M.L. Childrenʼs Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse. J Clin Oncol. 2023;41(25):4118–29. doi: 10.1200/JCO.22.02200.</mixed-citation><mixed-citation xml:lang="en">Hogan L.E., Brown P.A., Ji L., Xu X., Devidas M., Bhatla T., Borowitz M.J., Raetz E.A., Carroll A., Heerema N.A., Zugmaier G., Sharon E., Bernhardt M.B., Terezakis S.A., Gore L., Whitlock J.A., Hunger S.P., Loh M.L. Childrenʼs Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse. J Clin Oncol. 2023;41(25):4118–29. doi: 10.1200/JCO.22.02200.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Queudeville M., Ebinger M. Blinatumomab in Pediatric Acute Lymphoblastic Leukemia-From Salvage to First Line Therapy (A Systematic Review). J Clin Med. 2021;10(12):2544. doi: 10.3390/jcm10122544.</mixed-citation><mixed-citation xml:lang="en">Queudeville M., Ebinger M. Blinatumomab in Pediatric Acute Lymphoblastic Leukemia-From Salvage to First Line Therapy (A Systematic Review). J Clin Med. 2021;10(12):2544. doi: 10.3390/jcm10122544.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">van der Sluis I.M., de Lorenzo P., Kotecha R.S., Attarbaschi A., Escherich G., Nysom K., Stary J., Ferster A., Brethon B., Locatelli F., Schrappe M., Scholte-van Houtem P.E., Valsecchi M.G., Pieters R. Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia. N Engl J Med. 2023;388(17):1572–81. doi: 10.1056/NEJMoa2214171.</mixed-citation><mixed-citation xml:lang="en">van der Sluis I.M., de Lorenzo P., Kotecha R.S., Attarbaschi A., Escherich G., Nysom K., Stary J., Ferster A., Brethon B., Locatelli F., Schrappe M., Scholte-van Houtem P.E., Valsecchi M.G., Pieters R. Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia. N Engl J Med. 2023;388(17):1572–81. doi: 10.1056/NEJMoa2214171.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Martins M.V., de Lorenzo P., Kotecha R.S., Attarbaschi A., Escherich G., Nysom K., Stary J., Ferster A., Brethon B., Locatelli F., Schrappe M., Scholte-van Houtem P.E., Valsecchi M.G., Huitema A.D.R., Pieters R., van der Sluis I.M. Sustained Benefit of Blinatumomab in Infants With KMT2A-Rearranged ALL: Long-Term Outcomes, Toxicity, and Pharmacokinetics. J Clin Oncol. 2026;44(5):370–4. doi: 10.1200/JCO-25-01806.</mixed-citation><mixed-citation xml:lang="en">Martins M.V., de Lorenzo P., Kotecha R.S., Attarbaschi A., Escherich G., Nysom K., Stary J., Ferster A., Brethon B., Locatelli F., Schrappe M., Scholte-van Houtem P.E., Valsecchi M.G., Huitema A.D.R., Pieters R., van der Sluis I.M. Sustained Benefi t of Blinatumomab in Infants With KMT2A-Rearranged ALL: Long-Term Outcomes, Toxicity, and Pharmacokinetics. J Clin Oncol. 2026;44(5):370–4. doi: 10.1200/JCO-25-01806.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta S., Rau R.E., Kairalla J.A., Rabin K.R., Wang C., Angiolillo A.L., Alexander S., Carroll A.J., Conway S., Gore L., Kirsch I., Kubaney H.R., Li A.M., McNeer J.L., Militano O., Miller T.P., Moyer Y., OʼBrien M.M., Okada M., Reshmi S.C., Shago M., Wagner E., Winick N., Wood B.L., Haworth-Wright T., Zaman F., Zugmaier G., Zupanec S., Devidas M., Hunger S.P., Teachey D.T., Raetz E.A., Loh M.L. Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2025;392(9):875–91. doi: 10.1056/NEJMoa2411680.</mixed-citation><mixed-citation xml:lang="en">Gupta S., Rau R.E., Kairalla J.A., Rabin K.R., Wang C., Angiolillo A.L., Alexander S., Carroll A.J., Conway S., Gore L., Kirsch I., Kubaney H.R., Li A.M., McNeer J.L., Militano O., Miller T.P., Moyer Y., OʼBrien M.M., Okada M., Reshmi S.C., Shago M., Wagner E., Winick N., Wood B.L., Haworth-Wright T., Zaman F., Zugmaier G., Zupanec S., Devidas M., Hunger S.P., Teachey D.T., Raetz E.A., Loh M.L. Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2025;392(9):875–91. doi: 10.1056/NEJMoa2411680.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Maude S.L., Laetsch T.W., Buechner J., Rives S., Boyer M., Bittencourt H., Bader P., Verneris M.R., Stefanski H.E., Myers G.D., Qayed M., De Moerloose B., Hiramatsu H., Schlis K., Davis K.L., Martin P.L., Nemecek E.R., Yanik G.A., Peters C., Baruchel A., Boissel N., Mechinaud F., Balduzzi A., Krueger J., June C.H., Levine B.L., Wood P., Taran T., Leung M., Mueller K.T., Zhang Y., Sen K., Lebwohl D., Pulsipher M.A., Grupp S.A. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018;378(5):439–48. doi: 10.1056/NEJMoa1709866.</mixed-citation><mixed-citation xml:lang="en">Maude S.L., Laetsch T.W., Buechner J., Rives S., Boyer M., Bittencourt H., Bader P., Verneris M.R., Stefanski H.E., Myers G.D., Qayed M., De Moerloose B., Hiramatsu H., Schlis K., Davis K.L., Martin P.L., Nemecek E.R., Yanik G.A., Peters C., Baruchel A., Boissel N., Mechinaud F., Balduzzi A., Krueger J., June C.H., Levine B.L., Wood P., Taran T., Leung M., Mueller K.T., Zhang Y., Sen K., Lebwohl D., Pulsipher M.A., Grupp S.A. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018;378(5):439–48. doi: 10.1056/NEJMoa1709866.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Laetsch T.W., Maude S.L., Rives S., Hiramatsu H., Bittencourt H., Bader P., Baruchel A., Boyer M., De Moerloose B., Qayed M., Buechner J., Pulsipher M.A., Myers G.D., Stefanski H.E., Martin P.L., Nemecek E., Peters C., Yanik G., Khaw S.L., Davis K.L., Krueger J., Balduzzi A., Boissel N., Tiwari R., OʼDonovan D., Grupp S.A. Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial. J Clin Oncol. 2023;41(9):1664–9. doi: 10.1200/JCO.22.00642.</mixed-citation><mixed-citation xml:lang="en">Laetsch T.W., Maude S.L., Rives S., Hiramatsu H., Bittencourt H., Bader P., Baruchel A., Boyer M., De Moerloose B., Qayed M., Buechner J., Pulsipher M.A., Myers G.D., Stefanski H.E., Martin P.L., Nemecek E., Peters C., Yanik G., Khaw S.L., Davis K.L., Krueger J., Balduzzi A., Boissel N., Tiwari R., OʼDonovan D., Grupp S.A. ThreeYear Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial. J Clin Oncol. 2023;41(9):1664–9. doi: 10.1200/JCO.22.00642.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Li A.M., Maude S.L. With BiTEs at the kiddie table, where do CARs come in for pediatric B-ALL? Hematology Am Soc Hematol Educ Program. 2025;2025(1):443–9. doi: 10.1182/hematology.2025000735.</mixed-citation><mixed-citation xml:lang="en">Li A.M., Maude S.L. With BiTEs at the kiddie table, where do CARs come in for pediatric B-ALL? Hematology Am Soc Hematol Educ Program. 2025;2025(1):443–9. doi: 10.1182/hematology.2025000735.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Myers R.M., Taraseviciute A., Steinberg S.M., Lamble A.J., Sheppard J., Yates B., Kovach A.E., Wood B., Borowitz M.J., Stetler-Stevenson M., Yuan C.M., Pillai V., Foley T., Chung P., Chen L., Lee D.W., Annesley C., DiNofia A., Grupp S.A., John S., Bhojwani D., Brown P.A., Laetsch T.W., Gore L., Gardner R.A., Rheingold S.R., Pulsipher M.A., Shah N.N. Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL. J Clin Oncol. 2022;40(9):932–44. doi: 10.1200/JCO.21.01405.</mixed-citation><mixed-citation xml:lang="en">Myers R.M., Taraseviciute A., Steinberg S.M., Lamble A.J., Sheppard J., Yates B., Kovach A.E., Wood B., Borowitz M.J., Stetler-Stevenson M., Yuan C.M., Pillai V., Foley T., Chung P., Chen L., Lee D.W., Annesley C., DiNofi a A., Grupp S.A., John S., Bhojwani D., Brown P.A., Laetsch T.W., Gore L., Gardner R.A., Rheingold S.R., Pulsipher M.A., Shah N.N. Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL. J Clin Oncol. 2022;40(9):932–44. doi: 10.1200/JCO.21.01405.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Qi Y., Liu H., Li X., Shi Y., Mu J., Li J., Wang Y., Deng Q. Blinatumomab as salvage therapy in patients with relapsed/refractory B-ALL who have failed/progressed after anti-CD19-CAR T therapy. Ann Med. 2023;55(1):2230888. doi: 10.1080/07853890.2023.2230888.</mixed-citation><mixed-citation xml:lang="en">Qi Y., Liu H., Li X., Shi Y., Mu J., Li J., Wang Y., Deng Q. Blinatumomab as salvage therapy in patients with relapsed/refractory B-ALL who have failed/progressed after anti-CD19-CAR T therapy. Ann Med. 2023;55(1):2230888. doi: 10.1080/07853890.2023.2230888.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Cao W., Li N., Wang G., Xu H., Yang Y., Wang J., Xu J., Li Y., Zhang Y., Cao Y., Wang N. Efficacy and safety comparison of CAR-T and blinatumomab immunotherapy as bridge-to-transplant strategies in relapsed/refractory B cell acute lymphoblastic leukemia. J Transl Med. 2025;23(1):391. doi: 10.1186/s12967-025-06399-1.</mixed-citation><mixed-citation xml:lang="en">Cao W., Li N., Wang G., Xu H., Yang Y., Wang J., Xu J., Li Y., Zhang Y., Cao Y., Wang N. Effi  cacy and safety comparison of CAR-T and blinatumomab immunotherapy as bridge-to-transplant strategies in relapsed/refractory B cell acute lymphoblastic leukemia. J Transl Med. 2025;23(1):391. doi: 10.1186/s12967-025-06399-1.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Leahy A.B., Newman H., Li Y., Liu H., Myers R., DiNofia A., Dolan J.G., Callahan C., Baniewicz D., Devine K., Wray L., Aplenc R., June C.H., Grupp S.A., Rheingold S.R., Maude S.L. CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials. Lancet Haematol. 2021;8(10):e711–22. doi: 10.1016/S2352-3026(21)00238-6.</mixed-citation><mixed-citation xml:lang="en">Leahy A.B., Newman H., Li Y., Liu H., Myers R., DiNofi a A., Dolan J.G., Callahan C., Baniewicz D., Devine K., Wray L., Aplenc R., June C.H., Grupp S.A., Rheingold S.R., Maude S.L. CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from fi ve clinical trials. Lancet Haematol. 2021;8(10):e711–22. doi: 10.1016/S2352-3026(21)00238-6.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Burtsev E.A., Filina O.A., Juravel M.R., Kurmanov B.M., Tiganova O.A., Kondratchik K.L., Tenovskaya T.А., Gorev V.V., Valieva S.I., Gadjieva S.M., Kumirova E.V. Initial experience of successful usage of industrial CAR-T therapy with the tisagenlecleucel product in children with refractory B-ALL. Cellular Therapy and Transplantation. 2025;14(4):56–63. doi: 10.18620/ctt-1866-8836-2025-14-4-56-63.</mixed-citation><mixed-citation xml:lang="en">Burtsev E.A., Filina O.A., Juravel M.R., Kurmanov B.M., Tiganova O.A., Kondratchik K.L., Tenovskaya T.А., Gorev V.V., Valieva S.I., Gadjieva S.M., Kumirova E.V. Initial experience of successful usage of industrial CAR-T therapy with the tisagenlecleucel product in children with refractory B-ALL. Cellular Therapy and Transplantation. 2025;14(4):56–63. doi: 10.18620/ctt-1866-8836-2025-14-4-56-63.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
