nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”nodgo-134Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESОпыт комплексного лечения диссеминированной дисгерминомы яичника (описание клинического случая)Multimodal therapy of disseminated ovarian dysgerminoma (case report)АлябьеваМ. А.AlyabievaM. A.centrles.it@mail.ruФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России; Россия, 117198, Москва, ул. Саморы Машела, 1РоссияFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117198, RussiaRussian Federation201529092015237175Copyright © Алябьева М.А., 20152015Алябьева М.А.Alyabieva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/134

Герминогенно-клеточные опухоли являются редкими, но агрессивными новообразованиями у детей. Однако с использованием современных протоколов лечения достигнуты значительные успехи в выживаемости таких пациентов. В работе представлен разбор клинического случая диссеминированной дисгерминомы яичника с успешным применением комплексного лечения. Представлены литературные данные об эпидемиологии дисгерминомы яичника среди пациентов детского возраста, патогенезе дисгерминомы. Обсуждаются основные методы диагностики и принципы выбора тактики терапии.

Germ-cell tumors are rare, but aggressive tumors in children. The introduction of modern treatment protocols has significantly improved survival in this group of patients. This paper presents the analysis of clinical case of disseminated ovarian dysgerminoma successfully treated using multimodal therapeutic approach. The epidemiology of ovarian dysgerminoma among pediatric patients and the pathogenesis of the disease are discussed based on the analysis of the literature data. We also discuss the basic principles of diagnosis and choice of tactics of treatment.

педиатрияонкологиягерминогенно-клеточные опухолидисгерминомаяичникиоперацияполихимиотерапияpaediatricsoncologygerm cell tumorsdysgerminomaovarysurgerypolychemotherapyReferencesAmerican Cancer Society. Cancer Facts and Figures, 2014. Atlanta, GA: American Cancer Society. http://www.cancer.org/.American Cancer Society. Cancer Facts and Figures, 2014. Atlanta, GA: American Cancer Society. http://www.cancer.org/.Gobel U., Schneider D.T., Calaminus G. et al. Germ-cell tumors in childhood and adolescence. Ann Oncol 2000;11(3):263–71.Gobel U., Schneider D.T., Calaminus G. et al. Germ-cell tumors in childhood and adolescence. Ann Oncol 2000;11(3):263–71.Mangili G., Sigismondi C., Lorusso D., Pignata S. Surveillance policy for stage IA malignant ovarian germ cell tumors in children and young adults. J Clin Oncol 2014;32(25):2814–5.Mangili G., Sigismondi C., Lorusso D., Pignata S. Surveillance policy for stage IA malignant ovarian germ cell tumors in children and young adults. J Clin Oncol 2014;32(25):2814–5.Hanif J. Intra-abdominal tumors in children. J Coll Physicians Surg Pak 2004;14(8):478–80.Hanif J. Intra-abdominal tumors in children. J Coll Physicians Surg Pak 2004;14(8):478–80.Weinberg L.E., Lurain J.R., Singh D.K., Schink J.C. Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. Gynecol Oncol 2011;121(2):285–9.Weinberg L.E., Lurain J.R., Singh D.K., Schink J.C. Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. Gynecol Oncol 2011;121(2):285–9.Michener C.M., Huh W.K, Wu A.Y. et al. Ovarian Dysgerminomas. Medscape, 2015. http://emedicine.medscape.com/article/253701.Michener C.M., Huh W.K, Wu A.Y. et al. Ovarian Dysgerminomas. Medscape, 2015. http://emedicine.medscape.com/article/253701.Bidus M.A., Elkas J.C., Rose G.S. Clinical Gynecologic Oncology, 8th ed: Saunders, an imprint of Elsevier Inc, 2012. Pp. 329–356.Bidus M.A., Elkas J.C., Rose G.S. Clinical Gynecologic Oncology, 8th ed: Saunders, an imprint of Elsevier Inc, 2012. Pp. 329–356.Beryl R.B., Steven R.G., Yvette S.G. Gynecologic Ultrasound: A Problem-Based Approach: Saunders, an imprint of Elsevier Inc, 2014. Pp. 56–57.Beryl R.B., Steven R.G., Yvette S.G. Gynecologic Ultrasound: A Problem-Based Approach: Saunders, an imprint of Elsevier Inc, 2014. Pp. 56–57.Hyseni N., Llullaku S., Jashari H. et al. Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. Case Rep Oncol Med 2014;2014:910852.Hyseni N., Llullaku S., Jashari H. et al. Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. Case Rep Oncol Med 2014;2014:910852.Florette K., Teri A. Ovarian Dysgerminomas Pathology Overview of Ovarian Dysgerminomas. Medscape, 2013.http://emedicine.medscape.com/article/1951026.Florette K., Teri A. Ovarian Dysgerminomas Pathology Overview of Ovarian Dysgerminomas. Medscape, 2013.http://emedicine.medscape.com/article/1951026.Eleftherios P.D., Hervert A.F., Hans L. et al. Tumor Markers: Physiology, Pathobiology, Technology, and Clinical Applications. Washington, DC: AACC Press, 2002. P. 52.Eleftherios P.D., Hervert A.F., Hans L. et al. Tumor Markers: Physiology, Pathobiology, Technology, and Clinical Applications. Washington, DC: AACC Press, 2002. P. 52.Young G., Toretsky J., Campbell A., Eskenazi A. Recognition of common childhood malignancies. Am Fam Physician 2000;61(7):2144–54.Young G., Toretsky J., Campbell A., Eskenazi A. Recognition of common childhood malignancies. Am Fam Physician 2000;61(7):2144–54.Leman E., Gonzalgo M. Prognostic features and markers for testicular cancer management. Indian J Urol 2010;26(1):76–81.Leman E., Gonzalgo M. Prognostic features and markers for testicular cancer management. Indian J Urol 2010;26(1):76–81.Steyerberg E.W., Habbema J.D. Survival of non-seminomatous germ cell cancer patients according to the IGCC classification: An update based on meta-analysis. Eur J Cancer 2006;42(7):820–6.Steyerberg E.W., Habbema J.D. Survival of non-seminomatous germ cell cancer patients according to the IGCC classification: An update based on meta-analysis. Eur J Cancer 2006;42(7):820–6.

The authors declare that there are no conflicts of interest present.