nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2014-0-1-62-69nodgo-15Research ArticleОбзоры литературыСиндром опсоклонус-миоклонус и нейробластома (обзор литературы)Opsoclonus-myoclonus syndrome and neuroblastoma (a review of literature)КачановД. Ю.KachanovD. Yu.

Москва

Moscow

totti111@list.ruШаманскаяТатьяна ВикторовнаShamanskayaT. V.

Москва

Moscow

totti111@list.ruМалевичО. Б.MalevichO. B.

Москва

Moscow

totti111@list.ruВарфоломееваС. Р.VarfolomeevaS. R.

Москва

Moscow

totti111@list.ruФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава РоссииРоссияFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaRussian Federation201431032015016269Copyright © Качанов Д.Ю., Шаманская Т.В., Малевич О.Б., Варфоломеева С.Р., 20152015Качанов Д.Ю., Шаманская Т.В., Малевич О.Б., Варфоломеева С.Р.Kachanov D.Y., Shamanskaya T.V., Malevich O.B., Varfolomeeva S.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/15

Синдром опсоклонус-миоклонус (ОМС) является редким неврологическим синдромом. Длительное существование неврологических симптомов у пациентов без должного проведенного обследования и лечения, ошибки в диагнозе при первичном обращении больных свидетельствуют о том, что большинство врачей не осведомлены о данном синдроме и критериях его диагностики. Педиатр, который наблюдает ребенка раннего возраста с мозжечковой атаксией, должен знать о том, что это состояние может быть проявлением ОМС. С нейробластомой (НБ) ассоциированы 50 % случаев ОМС, развившегося в детском возрасте. Однако до настоящего времени возникают трудности в ранней диагностике этого состояния, определении объема инициального обследования и тактики терапии. В данной статье приведен обзор литературы, посвященный различным аспектам патогенеза, диагностики, клиники, лечения и прогноза при ОМС. Отдельно рассмотрены вопросы, посвященные ОМС, ассоциированному с НБ.

Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder. Chronic neurological symptoms in patients, improperly examined and treated, and diagnostic errors during their first visit to a doctor suggest that most physicians are unaware of this syndrome and criteria for its diagnosis. The pediatrician who follows up an infant with cerebellar ataxia must know that this condition may be a manifestation of OMS. 50 % of childhood-onset OMS cases are associated with neuroblastoma (NB). However, to date difficulties have emerged in the early diagnosis of this condition and in the determination of initial examination scope and therapy policy. This paper reviews the literature on different aspects of the pathogenesis, diagnosis, clinical presentation, treatment, and prognosis of OMS. The issues of NB-associated OMS are considered separately.

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The authors declare that there are no conflicts of interest present.