nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2016-3-2-18-30nodgo-208Research ArticleПРОБЛЕМЫ XXI ВЕКАTHE PROBLEMS OF THE 21 ST CENTURYКлинический обзор анти-CD19 BiTE® и ex vivo данных об анти-CD33 BiTE® в качестве примеров ретаргетирования Т-клеток при гематологических опухоляхClinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignanciesЗугмайерГ.ZugmaierG.КлингерМ.KlingerM.matthias.klinger@amgen.comШмидтМ.SchmidtM.СубклевеМ.SubkleweM.КиргизовК. И.KirgizovK. I.

Автор перевода

translator

ШаманскаяТ. В.ShamanskayaT. V.

Автор перевода

translator

Институт исследований Amgen, МюнхенГерманияAmgen Research (Munich) GmbH, MunichGermanyДепартамент внутренней медицины III, Мюнхенский университет, Мюнхен; Клиническое сотрудничество Группа иммунотерапии, Институт им. Гельмгольца, Мюнхен, ГерманияГерманияDepartment of Internal Medicine III, Klinikum der Universität München, Munich; Clinical Cooperation Group Immunotherapy, Helmholtz Institute Munich, MunichGermany201601062016321830Copyright © Зугмайер Г., Клингер М., Шмидт М., Субклеве М., Киргизов К.И., Шаманская Т.В., 20162016Зугмайер Г., Клингер М., Шмидт М., Субклеве М., Киргизов К.И., Шаманская Т.В.Zugmaier G., Klinger M., Schmidt M., Subklewe M., Kirgizov K.I., Shamanskaya T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/208

Блинатумомаб – биспецифичное антитело, созданное для воздействия на CD-19 клетки, является наиболее продвинутой частью биспецифических молекул, рекрутеров Т-клеток (BiTE®). Программа клинических исследований препарата включает такие нозологии, как В-клеточный острый лимфобластный лейкоз (ОЛЛ) и В-клеточную неходжкинскую лимфому (НХЛ). Достижения ремиссии удалось достичь как у взрослых, так и у детей с рефрактерным/рецидивирующим течением В-клеточного ОЛЛ, что позволило успешно выполнить аллогенную трансплантацию гемопоэтических стволовых клеток. Также блинатумомаб обладал стойким ответом к В-клеточной вялотекущей НХЛ. Блинатумомаб недавно получил одобрение FDA (США) для лечения рефрактерного/рецидивирующего ОЛЛ из клеток предшественников В-лимфоцитов, отрицательного по филадельфийской хромосоме. AMG 330 является исследовательским анти-CD33 BiTE®-антителом. Тестирование в режиме ex vivo на первичных образцах CD33-позитивных пациентов с острым миелоидным лейкозом показало экспансию и цитотоксический эффект против злокачественных клеток у AMG 330. 

Оригинальная статья “Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies” опубликована в журнале Mol Immunol 2015;67(2 Pt A):58–66. doi: 10.1016/j.molimm.2015.02.033. Epub 2015 Apr 13. Стиль и оформле- ние статьи сохранены. Все права защищены. © 2015 Elsevier Ltd.

Blinatumomab, a bispecific antibody construct targeting CD19, is the most advanced member of bis-pecific T-cell engager (BiTE®) molecules. The clinical development program includes B-precursor acute lymphoblastic leukemia (ALL) and B-cell non-Hodgkin lymphoma (NHL). Remissions induced in pediatric and adult patients with relapsed/refractory B-precursor ALL have allowed for successful allogeneic hematopoietic stem cell transplantation in this setting. Blinatumomab has also induced durable responses in low-grade B-cell NHL. Blinatumomab recently gained approval in the United States by the U.S. Food and Drug Administration for treatment of Philadelphia chromosome-negative B-precursor relapsed/refractory acute lymphoblastic leukemia. AMG 330 is an investigational anti-CD33 BiTE® antibody construct. Targeting CD33 ex vivo in primary samples from patients with acute myeloid leukemia (AML) has shown AMG 330-mediated T-cell expansion and T-cell cytotoxicity against AML cells.

“Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies” опубликована в журнале Mol Immunol 2015;67(2 Pt A):58–66. doi: 10.1016/j.molimm.2015.02.033. Epub 2015 Apr 13. Стиль и оформле- ние статьи сохранены. Все права защищены. © 2015 Elsevier Ltd.

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The authors declare that there are no conflicts of interest present.