nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2016-3-3-30-36nodgo-244Research ArticleИЗБРАННЫЕ ЛЕКЦИИSELECTED LECTURESВыбор донора при аллогенной трансплантации гемопоэтических стволовых клетокSelection of donor of allogeneic hematopoietic stem cell transplantationАфанасьевБ. В.AfanasievB. V.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

bmt-director@spb-gmu.ruЗубаровскаяЛ. С.ZubarovskayaL. S.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

АлянскийА. Л.AlyanskiyA. L.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

ПаинаО. В.PainaO. V.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

БоровковаА. С.BorovkovaA. S.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

КузьмичЕ. В.KuzmichYe. V.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

БыковаТ. А.BykovaT. A.

197022, Санкт-Петербург, ул. Л. Толстого, 6–8

6–8 L’va Tolstogo St., St. Petersburg, 197022

ДеевР. В.DeevR. V.

119333, Москва, Олимпийский просп., 18/1

18/1 Olimpiysky prospect, Moscow, 129110

ИсаевА. А.IsaevA. A.

119333, Москва, Олимпийский просп., 18/1

18/1 Olimpiysky prospect, Moscow, 129110

Научно-исследовательский институт детской гематологии, онкологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияRaisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St.Petersburg, Ministry of Health of RussiaRussian FederationПАО «Институт стволовых клеток человека»РоссияHuman Stem Cells InstituteRussian Federation201622092016333036Copyright © Афанасьев Б.В., Зубаровская Л.С., Алянский А.Л., Паина О.В., Боровкова А.С., Кузьмич Е.В., Быкова Т.А., Деев Р.В., Исаев А.А., 20162016Афанасьев Б.В., Зубаровская Л.С., Алянский А.Л., Паина О.В., Боровкова А.С., Кузьмич Е.В., Быкова Т.А., Деев Р.В., Исаев А.А.Afanasiev B.V., Zubarovskaya L.S., Alyanskiy A.L., Paina O.V., Borovkova A.S., Kuzmich Y.V., Bykova T.A., Deev R.V., Isaev A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/244

Выбор донора гемопоэтических стволовых клеток (ГСК), оптимально соответствующего реципиенту, является одним из основных условий успешности проведения аллогенной трансплантации и складывается из рассмотрения особенностей реципиента и предполагаемого донора, индивидуальные характеристики которых определяют тактику выполнения процедуры. Основными из них являются характер заболевания реципиента, совместимость по генам HLA-системы, тип донора (родственный, неродственный), источник ГСК (костный мозг, периферические стволовые клетки крови, пуповинная кровь). При гаплоидентичной трансплантации ГСК особое значение имеют возраст донора (до 30 лет), мужской пол, NIMA-несовместимость, наличие NK- аллореактивности. В настоящее время для каждого пациента, имеющего показания к аллогенной трансплантации, может быть найден донор, при этом последовательно должны быть рассмотрены следующие варианты: совместимый родственный донор; совместимый неродственный донор; частично совместимый неродственный донор (8/10 или 9/10); гаплоидентичный донор; пуповинная кровь; совместимый родственный донор после in vitro фертилизации с предимплантационной генетической диагностикой.

Selection of donor is the basis for success of allogeneic hematopoietic stem cell (HSC) transplantation (allo-HSCT). It needs to consider the individual characteristics of recipient and donor. The main of these are -disease, the HLA-matching, type of donor (related, unrelated), the source of HSC (BM, PBSC, umbilical cord blood). For haplo-HSCT particular importance are donor age below 30 years, male, NIMA incompatibility, NK-allo reactivity. Currently, for each patient, having indications for allo-HSCT, can be found allogeneic HSC donor. The following possibilities may be considered consequentially: a matched related donor; matched unrelated donor; partially matched unrelated donor (9/10 or 8/10); haploidentical donor; umbilical cord blood; matched sibling donor after in vitro fertilization – preimplantation genetic diagnosis.

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The authors declare that there are no conflicts of interest present.