nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2016-3-4-60-72nodgo-264Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ/ОБЗОРЫ ЛИТЕРАТУРЫORIGINAL INVESTIGATIONS/LITERATURE REVIEWSАнти-CD19-моноклональные антитела при острой лимфобластной лейкемии у детейAnti-CD19 monoclonal antibodies in acute lymphoblastic leukemia in childrenКарачунскийА. И.KarachunskiyA. I.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

aikarat@mail.ruРумянцеваЮ. В.RumyantsevaYu. V.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

фон ШтакельбергА.Fon ShtakelbergA.

Берлин

1 Augustenburger Platz, Berlin, 13353

ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России;РоссияFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia;Russian FederationУниверситетская клиника педиатрии, специализирующаяся в онкологии и гематологии, Университетского медицинского комплекса ШаритеГерманияKlinik für Pädiatrie mit Schwerpunkt Onkologie und Hämatologie, Charité - Universitätsmedizin Berlin;Germany201617012017346072Copyright © Карачунский А.И., Румянцева Ю.В., фон Штакельберг А., 20172017Карачунский А.И., Румянцева Ю.В., фон Штакельберг А.Karachunskiy A.I., Rumyantseva Y.V., fon Shtakelberg A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/264

Разработка моноклональных антител для лечения гемобластозов является быстро развивающейся областью науки. Ряд соединений оказался эффективен при лечении острого лимфобластного лейкоза (ОЛЛ) у детей. В то время как неконъюгированные гуманизированные антитела хорошо переносимы и могут быть легко объединены с химиотерапией, иммуноконъюгаты, доставляющие токсические соединения прямо в клетки-мишени, имеют более серьезные побочные эффекты. Антигены с высокой и селективной экспрессией являются идеальными мишенями для использования антител и подходят для исследований фазы I/II и III при ОЛЛ у детей. Антигены, стабильно экспрессирующиеся на поверхности клетки, подходят как для неконъюгированных антител, вызывающих антитело-зависимую клеточную и комплемент-зависимую цитотоксичность, так и для биспецифических антител с участием Т-клеток. Моноклональные антитела обладают совершенно иным механизмом действия по сравнению с таковым обычной химиотерапии и, безусловно, способны существенно изменить стратегию лечения ОЛЛ в будущем.

Creation of monoclonal antibodies for leukaemia treatment is rapidly developing area of science. A number of compounds were effective for treatment of acute lymphoblastic leukaemia (ALL) at children. While unconjugated humanized antibodies have good tolerability and can be combined with chemotherapy, immunoconjugates, delivering the toxic compounds directly to the target cells, have more serious adverse effects. Antigens with high and selective expression are the ideal targets for usage with antibodies and suitable for studies of phases I/II and III in case of pediatric ALL. Antigens with stable expression on the cells surfaces, suitable both for unconjugated antibodies, leading to antibodies-dependent cell and complement-dependent cytotoxicity, and for bispecific antibodies with participation of T-cells. Monoclonal antibodies have quite different mechanism of action in comparison with routine chemotherapy and, of course, can change the strategy of ALL treatment in future.

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The authors declare that there are no conflicts of interest present.