nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2017-4-1-71-76nodgo-284Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESСочетание бифокальной герминомы и артериовенозной мальформации головного мозга в детском возрасте. Клиническое наблюдение и обзор литературыThe combination of a bifocal germinoma and arteriovenous malformations of the brain in children. Clinical observation and review of the literatureСальниковаЕ. А.SalnikovaE. A.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

ea_gerasimova@mail.ruОзеровС. С.OzerovS. S.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

СамаринА. Е.SamarinA. E.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

АнаньеваН. П.AnanievaN. P.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

КобызеваД. А.KobyzevaD. A.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

НечеснюкА. В.NechesnyukA. V.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

ЕмцоваВ. В.EmtsovaV. V.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

АлексеевМ. А.AlekseevM. A.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

ХомяковаС. П.KhomyakovaS. P.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

БогинскаяО. А.BoginskayaO. A.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

ЛитвиновД. В.LitvinovD. V.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

КумироваЭ. В.KumirovaE. V.

117997, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117997

ФГБУ «ННПЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201701032017417176Copyright © Сальникова Е.А., Озеров С.С., Самарин А.Е., Ананьева Н.П., Кобызева Д.А., Нечеснюк А.В., Емцова В.В., Алексеев М.А., Хомякова С.П., Богинская О.А., Литвинов Д.В., Кумирова Э.В., 20172017Сальникова Е.А., Озеров С.С., Самарин А.Е., Ананьева Н.П., Кобызева Д.А., Нечеснюк А.В., Емцова В.В., Алексеев М.А., Хомякова С.П., Богинская О.А., Литвинов Д.В., Кумирова Э.В.Salnikova E.A., Ozerov S.S., Samarin A.E., Ananieva N.P., Kobyzeva D.A., Nechesnyuk A.V., Emtsova V.V., Alekseev M.A., Khomyakova S.P., Boginskaya O.A., Litvinov D.V., Kumirova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/284

Первичные интракраниальные герминативно-клеточные опухоли (ИГКО) являются редкой гетерогенной группой неоплазий, представленной несколькими гистологическими вариантами с различным биологическим профилем и ответом на терапию. Чистые герминомы составляют не более 5 % среди злокачественных новообразований центральной нервной системы у детей, на долю бифокальных гермином приходится лишь 5–10 % всех гермином. В лечении ИГКО применяются лучевая терапия и полихимиотерапия, выбор инициальной лечебной опции зависит от гистологического варианта новообразования и распространенности процесса.

Сосудистые мальформации головного мозга редко встречаются в детском возрасте, в большой доле случаев они являются случайной находкой, что способно существенно повлиять на лечебную тактику при наличии иной патологии головного мозга (например, неопластического процесса).

В статье представлен редкий клинический случай сочетания бифокальной герминомы и артериовенозной мальформации головного мозга у мальчика 13 лет.

Primary intracranial germ cell tumors are rare heterogeneous group of neoplasms presented several histological types with different biological profile and response to therapy. Pure germinomas make up no more than 5 % of malignant tumors of the central nervous system in children, bifocal germinomas account for only 5–10 % of all germinomas. Radiotherapy and chemotherapy are usually used in intracranial germ cell tumors. The choice of initial therapy options is dependent on the histological variants of tumors, and the prevalence of the process (M-stage). Vascular malformations of the brain is rare in childhood, in a large proportion of cases, which is a random finding and can significantly affect the treatment policy in the presence of a brain disease (eg, neoplasia).

We present a rare case of a combination of clinical bifocal germinomas and arteriovenous malformations of the brain in a boy 13 years old

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The authors declare that there are no conflicts of interest present.