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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/2311-1267-2017-4-1-83-88</article-id><article-id custom-type="elpub" pub-id-type="custom">nodgo-287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE STUDY</subject></subj-group></article-categories><title-group><article-title>Гетерогенность 4S стадии нейробластомы: мультидисциплинарный взгляд</article-title><trans-title-group xml:lang="en"><trans-title>Heterogeneity of neuroblastoma stage 4S: a multidisciplinary view</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаманская</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shamanskaya</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><email xlink:type="simple">shamanskaya.tatyana@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Качанов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kachanov</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Феоктистова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Feoktistova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ликарь</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Likar</surname><given-names>Yu. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муфтахова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Muftakhova</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Талыпов</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Talypov</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варфоломеева</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Varfolomeeva</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ННПЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>01</day><month>03</month><year>2017</year></pub-date><volume>4</volume><issue>1</issue><fpage>83</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шаманская Т.В., Качанов Д.Ю., Феоктистова Е.В., Терещенко Г.В., Ликарь Ю.Н., Муфтахова Г.М., Талыпов С.Р., Варфоломеева С.Р., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Шаманская Т.В., Качанов Д.Ю., Феоктистова Е.В., Терещенко Г.В., Ликарь Ю.Н., Муфтахова Г.М., Талыпов С.Р., Варфоломеева С.Р.</copyright-holder><copyright-holder xml:lang="en">Shamanskaya T.V., Kachanov D.Y., Feoktistova E.V., Tereshchenko G.V., Likar Y.N., Muftakhova G.M., Talypov S.R., Varfolomeeva S.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/287">https://journal.nodgo.org/jour/article/view/287</self-uri><abstract><p>4S стадия является уникальной и гетерогенной метастатической формой нейробластомы – наиболее частой экстракраниальной солидной опухоли детского возраста. Крайне важным является мультидисциплинарный подход к ведению данной группы пациентов, от момента постановки диагноза до выработки терапевтического плана и схемы динамического наблюдения.</p></abstract><trans-abstract xml:lang="en"><p>4S stage is unique and heterogeneous metastatic neuroblastoma - the most common extracranial solid tumor of childhood. Extremely important is the multidisciplinary approach to the management of this group of patients, from diagnosis to the development of a therapeutic plan and scheme of dynamic observation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нейробластома</kwd><kwd>дети</kwd><kwd>4S стадия</kwd><kwd>сцинтиграфия с метайодбензилгуанидином</kwd><kwd>ультразвуковая диагностика</kwd><kwd>магнитно-резонансная томография</kwd><kwd>полихимиотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuroblastoma</kwd><kwd>children</kwd><kwd>stage 4S</kwd><kwd>scintigraphy with meta-iodobenzylguanidine</kwd><kwd>ultrasound diagnostics</kwd><kwd>magnetic resonance imaging</kwd><kwd>chemotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung N.K., Dyer M.A. Neuroblastoma: developmental biology, cancer genomics and immunotherapy. 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