<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/2311-1267-2017-4-3-276-287</article-id><article-id custom-type="elpub" pub-id-type="custom">nodgo-310</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИЗБРАННЫЕ ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SELECTED LECTURES</subject></subj-group></article-categories><title-group><article-title>Инновационные достижения в области онкологии</article-title><trans-title-group xml:lang="en"><trans-title>Innovative achievements in the field of oncology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добреньков</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrenkov</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">dobrenkov@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>09</month><year>2017</year></pub-date><volume>4</volume><issue>3</issue><fpage>10</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Добреньков К.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Добреньков К.В.</copyright-holder><copyright-holder xml:lang="en">Dobrenkov K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/310">https://journal.nodgo.org/jour/article/view/310</self-uri><abstract><p>В лекции рассмотрен вопрос о том, как под влиянием последних научных открытий и введения в практику новых препаратов поменялся сам терапевтический подход в области онкологии. Отдельно обсуждена разработка иммунотерапевтических препаратов в рамках концепции взаимодействия опухоли и организма, когда мы рассматриваем опухоль не как отдельную, но как составную часть организма, непрерывно взаимодействующую с различными органами и системами, включая иммунную. Также рассмотрен вопрос о новых концепциях использования иммунотерапии в клинической практике. На примере антитела к GD2- антигену я расскажу о процессе создания и внедрения в клинику антител и как это повлияло на результаты лечения одной из самых частых солидных опухолей у детей – нейробластомы.</p></abstract><trans-abstract xml:lang="en"><p>Lecture considering question of changing of therapeutic approach in the field of oncology under the influence of recent scientific findings and implementation of new drugs. Separately discussed development of drugs for immunotherapy in the concept of relations between tumor and organism when we considering tumor as not a separate, but as a composite part of organism continuously interacting with different organs and systems, including immune system. Question of new concepts of application of immunotherapy in clinical practice also considered. Based on example of antibody to GD2-antigen I will tell about the process of creation and implementation of antibodies to the practice and how this process influenced on the results of treatment of one of the most frequent solid tumors at children – neuroblastoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>иммунотераия</kwd><kwd>инновации</kwd><kwd>антитела</kwd><kwd>GD2-антиген</kwd><kwd>нейробластома</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>immunotherapy</kwd><kwd>innovations</kwd><kwd>antibodies</kwd><kwd>GD2 antigen</kwd><kwd>neuroblastoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
