nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2018-5-1-56-63nodgo-359Research ArticleОбзоры литературыСовременные представления о лечении лимфомы Ходжкина у детей и подростков. Обзор литературыContemporary representations about the treatment of Hodgkin’s lymphoma in children and adolescents. ReviewЕвстратовД. А.EvstratovD. A.

Дмитрий Андреевич Евстратов 

117997, Москва, ул. Саморы Машела, 1

Evstratov.D.A@yandex.ruПшонкинА. В.PshonkinA. V.МяковаН. В.MyakovaN. V.ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201820022018515663Copyright © Евстратов Д.А., Пшонкин А.В., Мякова Н.В., 20182018Евстратов Д.А., Пшонкин А.В., Мякова Н.В.Evstratov D.A., Pshonkin A.V., Myakova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/359

Классическая лимфома Ходжкина (ЛХ) у детей и подростков является одной из наиболее хорошо излечиваемых опухолей. Однако при длительном периоде наблюдения у реконвалесцентов отмечается повышение смертности от вторичных опухолей, цереброваскулярных заболеваний и патологий сердечно-сосудистой системы. Основную роль в возникновении отсроченных осложнений играет лучевая терапия. В современных протоколах лечения ЛХ у детей и подростков проводится оптимизация терапии в зависимости от групп риска и оценки раннего ответа на индукционную терапию для максимального уменьшения возможных побочных эффектов.

Для наиболее эффективного распределения пациентов на группы риска в настоящее время используют несколько факторов риска, основанных на клинических, инструментальных и лабораторных показателях. Ведущее место в проведении стадирования заняла позитронно-эмиссионная томография. Современные подходы диагностики и лечения ЛХ требуют проведения мультицентрового исследования с централизованным пересмотром гистологических препаратов и визуализации для оптимизации терапии у детей и подростков. 

Classical Hodgkin’s lymphoma (HL) in children and adolescents is one of the most well-cured tumors. However, during a long period of follow-up, the death rate from secondary tumors, cerebrovascular diseases and diseases of the cardiovascular system is increased in the reconvalescents. Radiation therapy plays a major role in the occurrence of delayed complications. Modern protocols for the treatment of HL in children and adolescents optimize therapy depending on risk groups and the level of the early response to induction therapy in order to minimize the number of possible side effects.

Nowadays for the most efficient allocation of patients to risk currently there are several risk factors based on clinical, instrumental and laboratory indicators. The leading place in the staging took positron emission tomography. Modern approaches to diagnosis and treatment of HL require a multicenter study with a centralized revision of histological preparations and visualization data to optimize therapy in children and adolescents. 

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The authors declare that there are no conflicts of interest present.