nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2018-5-2-45-49nodgo-383Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESКлинический случай спонтанного достижения ремиссии острого миелобластного лейкоза у пациентки с реактивацией цитомегаловирусной инфекции и последующими повторными отторжениями гемопоэтического трансплантата, обусловленными цитотоксическими лимфоцитамиClinical case of spontaneous remission of acute myeloblastic leukemia in a patient with reactivation of cytomegalovirus infection and subsequent repeated rejections of a hemopoietic graft caused by cytotoxic lymphocytesМезенцеваА. В.MezentsevaA. V.mezentseva_a_v@mail.ruФГБУ «РДКБ» Минздрава РоссииРоссияRussian Children’s Clinical Hospital, Ministry of Health of RussiaRussian Federation201823042018524549Copyright © Мезенцева А.В., 20182018Мезенцева А.В.Mezentseva A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/383

Цитомегаловирусная (ЦМВ) инфекция является одним из распространенных осложнений среди пациентов, получающих полихимиотерапию. Однако вопрос влияния ЦМВ-инфекции вне контекста аллогенной трансплантации гемопоэтических стволовых клеток остается малоизученным. В статье представлен редкий клинический случай – достижение полной клинико-гематологической ремиссии рефрактерной нейролейкемии на фоне ЦМВ-инфекции у пациентки с острым миелобластным лейкозом, с последующими отторжениями гемопоэтических трансплантатов на фоне активизации TcRα/β-клона лимфоцитов и ЦМВ-виремии.

Cytomegalovirus (CMV) infection is one of the most an issue of common complications among patients receiving polychemotherapy. However, the question of the influence of CMV infection remains under-explored outside the context of allogeneic transplantation of hematopoietic stem cells. The article presents a rare clinical case – achievement of complete clinical and hematological remission of refractory neuraleukemia against CMV infection in a patient with acute myeloblastic leukemia, followed by rejection of hematopoietic transplants against the background of activation of the TcRα/β-clone of lymphocytes and CMV viremia.

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The authors declare that there are no conflicts of interest present.