nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2018-5-2-50-55nodgo-384Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESБилатеральная нефробластома у детей. Описание клинического случаяBilateral nephroblastoma in children. Description of the clinical caseКазаковаЛ. Л.KazakovaL. L.lilkin2013@mail.ruФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201823042018525055Copyright © Казакова Л.Л., 20182018Казакова Л.Л.Kazakova L.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/384

Совершенствование методов диагностики и лечения злокачественных новообразований у детей остается одной из главных задач современной педиатрии. Несмотря на успехи, достигнутые при лечении монолатеральной нефробластомы, двустороннее поражение почек опухолью Вильмса вызывает целый ряд трудностей у врачей-детских онкологов на этапе диагностики, в особенности при выборе стратегии и тактики противоопухолевой терапии. В статье представлено описание клинического случая развития билатеральной нефробластомы у ребенка 5 лет.

Improving the methods of diagnostic and treating malignant neoplasms in children remain a major challenge of modern pediatrics. Despite of the achievements made in the treatment of the monolateral nephroblastoma, the ambilateral kidney dysfunction by the Wilms tumor induses a number of difficulties among the pediatric oncologist at the diagnostic phase, particularly in the setting of the strategy and tactics used in the antitumor therapy. This article represents clinical case of decreasing Bilateral nephroblastoma in children of 5 years.

билатеральная нефробластомадвустороннее поражение почекновообразование почкиопухоль Вильмсадетиbilateral nephroblastomabilateral renal damagekidney neoplasmWilms tumorchildrenReferencesErginel B., Vural S., Akin M. et al. Wilms’ tumor: a 24-year retrospective study from a single center. Pediatr Hematol Oncol 2014;31(5):409– 14. doi: 10.3109/08880018.2014.930767.Erginel B., Vural S., Akin M. et al. Wilms’ tumor: a 24-year retrospective study from a single center. Pediatr Hematol Oncol 2014;31(5):409– 14. doi: 10.3109/08880018.2014.930767.Hoffer F.A. Magnetic resonance imaging of abdominal masses in the pediatric patient. Semin Ultrasound CT MR 2005;26(4):212–23. PMID: 16152736.Hoffer F.A. Magnetic resonance imaging of abdominal masses in the pediatric patient. Semin Ultrasound CT MR 2005;26(4):212–23. PMID: 16152736.Алиев М.Д., Поляков В.Г., Менткевич Г.Л., Маякова С.А. Детская онкология. Национальное руководство. М.: Издательская группа РОНЦ, Практическая медицина, 2012. 684 с. [Aliev M.D., Polyakov V.G., Mentkevich G.L., Mayakova S.A. Pediatric oncology. National guidelines. M.: Publishing group RONTS, Practicheskaya meditsina, 2012. 684 p. (In Russ.)].Алиев М.Д., Поляков В.Г., Менткевич Г.Л., Маякова С.А. Детская онкология. Национальное руководство. М.: Издательская группа РОНЦ, Практическая медицина, 2012. 684 с. [Aliev M.D., Polyakov V.G., Mentkevich G.L., Mayakova S.A. Pediatric oncology. National guidelines. M.: Publishing group RONTS, Practicheskaya meditsina, 2012. 684 p. (In Russ.)].Peres E.M., Savasan S., Cushing В. et al. Chromosome analyses of 16 cases of Wilms tumor: different pattern in unfavorable histology. Cancer Genet Cytogenet 2004;148(1):66–70. PMID: 14697643.Peres E.M., Savasan S., Cushing В. et al. Chromosome analyses of 16 cases of Wilms tumor: different pattern in unfavorable histology. Cancer Genet Cytogenet 2004;148(1):66–70. PMID: 14697643.Perotti D., Mondini P., Terenziani M. et al. WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities. J Pediatr Hematol Oncol 2005;27(4):197–201. PMID: 15838390.Perotti D., Mondini P., Terenziani M. et al. WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities. J Pediatr Hematol Oncol 2005;27(4):197–201. PMID: 15838390.Faria P., Beckwith J.B., Mishra K. et al. Focal versus diffuse anaplasia in Wilms tumor-new definitions with prognostic significance: a report from the National Wilms Tumor Study Group. Am J Surg Pathol 1996;20(8):909–20. PMID: 8712292.Faria P., Beckwith J.B., Mishra K. et al. Focal versus diffuse anaplasia in Wilms tumor-new definitions with prognostic significance: a report from the National Wilms Tumor Study Group. Am J Surg Pathol 1996;20(8):909–20. PMID: 8712292.Bardeesy N., Falkoff D., Petruzzi M.J. et al. Anaplastic Wilms’ tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet 1994;7(1):91–7. doi: 10.1038/ ng0594-91.Bardeesy N., Falkoff D., Petruzzi M.J. et al. Anaplastic Wilms’ tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet 1994;7(1):91–7. doi: 10.1038/ ng0594-91.Breslow N., Sharples K., Beckwith J.B. et al. Prognostic factors in nonmetastatic, favorable histology Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer 1991;68(11):2345–53. PMID: 1657352.Breslow N., Sharples K., Beckwith J.B. et al. Prognostic factors in nonmetastatic, favorable histology Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer 1991;68(11):2345–53. PMID: 1657352.Ehrlich P., Chi Y.Y., Chintagumpala M.M. et al. Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534): A Report From the Children’s Oncology Group. Ann Surg 2017;266(3):470–8. doi: 10.1097/ SLA.0000000000002356.Ehrlich P., Chi Y.Y., Chintagumpala M.M. et al. Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534): A Report From the Children’s Oncology Group. Ann Surg 2017;266(3):470–8. doi: 10.1097/ SLA.0000000000002356.

The authors declare that there are no conflicts of interest present.