nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2019-6-1-61-66nodgo-473Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESКлинический случай излечения генерализованной аденовирусной инфекции на фоне реакции «трансплантат против хозяина» у ребенка после трансплантации костного мозга от гаплоидентичного донораClinical case of curing a generalized adenovirus infection on the background of graft versus host reaction in a child after bone marrow transplantation from a haploidentical donorhttps://orcid.org/0000-0003-3211-6158МезенцеваА. В.MezentsevaA. V.

врач-гематолог отделения трансплантации костного мозга

Hematologist Department of Bone Marrow Transplantation

mezentseva_a_v@mail.ruhttps://orcid.org/0000-0003-4431-1444СкоробогатоваЕ. В.SkorobogatovaE. V.

д.м.н., заведующая отделением трансплантации костного мозга

Dr. of Sci. (Med.), Head of Bone Marrow Transplantation Department

skorobog.e@mail.ruhttps://orcid.org/0000-0003-4170-7152БуряА. Е.BuryaA. E.

врач-гематолог отделения трансплантации костного мозга

Hematologist Department of Bone Marrow Transplantation

burya.a.e@gmail.comhttps://orcid.org/0000-0002-2945-284XКиргизовК. И.KirgizovK. I.

к.м.н., заместитель директора Института управления и трансляционной медицины НМИЦ ДГОИ им. Дмитрия Рогачева

Cand. of Sci. (Med.), Deputy Director of the Institute of Management and Translational Medicine Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

kirgiz-off@yandex.ruhttps://orcid.org/0000-0002-2652-8642КонстантиноваВ. В.KonstantinovaV. V.

врач-гематолог отделения трансплантации костного мозга

Hematologist Department of Bone Marrow Transplantation

veronika_md@mail.ruhttps://orcid.org/0000-0003-2395-4045МачневаЕ. Б.MachnevaE. B.

к.м.н., врач-гематолог отделения трансплантации костного мозга

Cand. of Sci. (Med.), Hematologist Department of Bone Marrow Transplantation

lena.machneva@yandex.ruhttps://orcid.org/0000-0002-4569-657XПристансковаЕ. А.PristanskovaE. A.

заведующая отделением гематологии и химиотерапии № 1

Head of the Department of Hematology and Chemotherapy № 1

eprist82@mail.ruРоссийская детская клиническая больница ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияRussian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian FederationРоссийская детская клиническая больница ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияRussian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201911022019616166Copyright © Мезенцева А.В., Скоробогатова Е.В., Буря А.Е., Киргизов К.И., Константинова В.В., Мачнева Е.Б., Пристанскова Е.А., 20192019Мезенцева А.В., Скоробогатова Е.В., Буря А.Е., Киргизов К.И., Константинова В.В., Мачнева Е.Б., Пристанскова Е.А.Mezentseva A.V., Skorobogatova E.V., Burya A.E., Kirgizov K.I., Konstantinova V.V., Machneva E.B., Pristanskova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/473

Аденовирусная инфекция является одной из причин трансплантационно-ассоциированной смертности после аллогенной трансплантации гемопоэтических стволовых клеток. Фульминантная печеночная недостаточность при аденовирусной инфекции представляет диагностическую и терапевтическую проблему в связи с ее агрессивным клиническим течением и крайне неблагоприятным прогнозом, при этом современные методы терапии аденовирусной инфекции основаны на использовании виростатических препаратов и вирус-специфичных лимфоцитов и ассоциированы с тяжелыми побочными эффектами. В статье представлен редкий клинический случай элиминации диссеминированной аденовирусной инфекции с фульминантно развивающейся печеночной недостаточностью у пациента после аллогенной трансплантации костного мозга от гаплоидентичного донора.

Adenovirus infection is one of the causes of transplant-associated mortality after allogeneic hematopoietic stem cell transplantation. Fulminant liver failure with adenovirus infection is a diagnostic and therapeutic problem due to its aggressive clinical course and extremely poor prognosis, while modern methods of treating adenovirus infection are based on the use of virostatic drugs and virus-specific lymphocytes and are associated with severe side effects. The article presents a rare clinical case of elimination of disseminated adenoviral infection with fulminantly developing liver failure in a patient after allogeneic bone marrow transplantation from a haploidentical donor.

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The authors declare that there are no conflicts of interest present.