nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2019-6-3-44-53nodgo-525Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESМеланотическая нейроэктодермальная опухоль младенцев: описание опыта НМИЦ ДГОИ им. Дмитрия Рогачева и обзор литературыMelanotic neuroectodermal tumor of infancy: a description of the experience of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology and literature reviewhttps://orcid.org/0000-0002-5489-1879СулеймановаА. М.SuleymanovaA. M.

Амина Магомедовна Сулейманова

врач-детский онколог отделения хирургии № 2 (опухолей торакоабдоминальной локализации)

115478, Москва, Каширское шоссе, 23

Pediatric Oncologist Department of Surgery No. 2 (Tumors of Thoracoabdominal Localization) Research Institute of Pediatric Oncology and Hematology

23 Kashirskoe Shosse, Moscow, 115478

aminasuleymanova313@gmail.comОзеровС. С.OzerovS. S.

к.м.н., врач-нейрохирург отделения онкологии и детской хирургии, главный научный сотрудник отдела нейроонкологии

117997, Москва, ул. Саморы Машела, 1

Cand. of Sci. (Med.), Neurosurgeon of the Department of Oncology and Pediatric Surgery, Chief Researcher of the Department of Neurooncology

1 Samory Mashela St., Moscow, 117997

Gagara3@yandex.ruhttps://orcid.org/0000-0002-9375-7517РощинВ. Ю.RoshchinV. Yu.

врач-патологоанатом патологоанатомического отделения

117997, Москва, ул. Саморы Машела, 1

Pathologist of the Pathology Department

1 Samory Mashela St., Moscow, 117997

vit1982@list.ruhttps://orcid.org/0000-0002-4451-3233ГрачёвН. С.GrachevN. S.

д.м.н., врач-онколог, заведующий отделением онкологии и детской хирургии, руководитель группы хирургии головы и шеи и реконструктивно-пластической хирургии отдела хирургии и анестезиологии, заместитель директора Института онкологии, радиологии и ядерной медицины

117997, Москва, ул. Саморы Машела, 1

Dr. of Sci. (Med.), Oncologist, Head of the Department of Oncology and Pediatric Surgery, Head of the Head and Neck Surgery and Reconstructive Plastic Surgery Unit of the Department of Surgery and Anesthesiology, Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine

1 Samory Mashela St., Moscow, 117997

nick-grachev@yandex.ruhttps://orcid.org/0000-0001-6313-6712БольшаковН. А.BolshakovN. A.

врач-ортопед-травматолог отделения онкологии и детской хирургии

117997, Москва, ул. Саморы Машела, 1

Orthopedic and Traumatologist of the Department of Oncology and Pediatric Surgery

1 Samory Mashela St., Moscow, 117997

bolshakovn@yandex.ruhttps://orcid.org/0000-0003-1308-8622ДруйА. Е.DruyA. E.

к.м.н., врач клинической лабораторной диагностики лаборатории цитогенетики и молекулярной генетики

117997, Москва, ул. Саморы Машела, 1

Cand. of Sci. (Med.), Doctor of Clinical Laboratory Diagnostics Laboratory of Cytogenetics and Molecular Genetics

1 Samory Mashela St., Moscow, 117997

dr-drui@yandex.ruhttps://orcid.org/0000-0001-7317-7104ТерещенкоГ. В.TereshchenkoG. V.

к.м.н., врач-рентгенолог, заведующая рентгенологическим отделением

117997, Москва, ул. Саморы Машела, 1

Cand. of Sci. (Med.), Radiologist, Head of the Radiology Department

1 Samory Mashela St., Moscow, 117997

galina.tereshenko@fccho-moscow.ruКоноваловД. М.KonovalovD. M.

к.м.н., заведующий патологоанатомическим отделением

117997, Москва, ул. Саморы Машела, 1

 

Cand. of Sci. (Med.), Pathologist, Head of the Pathology Department

1 Samory Mashela St., Moscow, 117997

pathmorf@mail.ruhttps://orcid.org/0000-0002-7846-3473СагоянГ. Б.SagoyanG. B.

врач-детский онколог отделения хирургии № 2 (опухолей торакоабдоминальной локализации) НИИ детской онкологии и гематологии

115478, Москва, Каширское шоссе, 23

Pediatric Oncologist Department of Surgery No. 2 (Tumors of Thoracoabdominal Localization)

23 Kashirskoe Shosse, Moscow, 115478

sagoyan-garik@mail.ruhttps://orcid.org/0000-0002-3767-4477ШаманскаяТ. В.ShamanskayaT. V.

к.м.н., ученый секретарь Института онкологии, радиологии и ядерной медицины

117997, Москва, ул. Саморы Машела, 1

Cand. of Sci. (Med.), Academic Secretary of the Institute of Oncology, Radiology and Nuclear Medicine

1 Samory Mashela St., Moscow, 117997

shamanskaya.tatyana@gmail.comhttps://orcid.org/0000-0002-3704-8783КачановД. Ю.KachanovD. Yu.

д.м.н., заведующий отделением клинической онкологии, заместитель директора Института онкологии, радиологиии ядерной медицины, SPIN-код: 9878-5540

117997, Москва, ул. Саморы Машела, 1

Dr. of Sci. (Med.), Head of the Department of Clinical Oncology and Department of Embryonic Tumor Research & Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine, SPIN-code: 9878-5540

1 Samory Mashela St., Moscow, 117997

Denis.Kachanov@fccho-moscow.ruhttps://orcid.org/0000-0001-6131-1783ВарфоломееваС. Р.VarfolomeevaS. R.

д.м.н., профессор, заместитель директора по научной и лечебной работе – директор НИИ детской онкологии и гематологии аппарата управления, исполнительный директор РОО НОДГО

115478, Москва, Каширское шоссе, 23

Dr. of Sci. (Med.), Professor, Deputy Director for Research and Clinical Work – Director

23 Kashirskoe Shosse, Moscow, 115478

clinoncology@gmail.comНИИ детской онкологии и гематологии ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияResearch Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of RussiaRussian FederationФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201922092019634453Copyright © Сулейманова А.М., Озеров С.С., Рощин В.Ю., Грачёв Н.С., Большаков Н.А., Друй А.Е., Терещенко Г.В., Коновалов Д.М., Сагоян Г.Б., Шаманская Т.В., Качанов Д.Ю., Варфоломеева С.Р., 20192019Сулейманова А.М., Озеров С.С., Рощин В.Ю., Грачёв Н.С., Большаков Н.А., Друй А.Е., Терещенко Г.В., Коновалов Д.М., Сагоян Г.Б., Шаманская Т.В., Качанов Д.Ю., Варфоломеева С.Р.Suleymanova A.M., Ozerov S.S., Roshchin V.Y., Grachev N.S., Bolshakov N.A., Druy A.E., Tereshchenko G.V., Konovalov D.M., Sagoyan G.B., Shamanskaya T.V., Kachanov D.Y., Varfolomeeva S.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/525

Меланотическая нейроэктодермальная опухоль младенцев (МНЭО) относится к редким опухолям с неопределенным биологическим поведением. Наиболее часто МНЭО локализуются в области головы и шеи. Стандартом терапии является радикальное хирургическое удаление опухоли, что зачастую сопряжено с высокими рисками тяжелых послеоперационных осложнений за счет локализации опухоли. В случае метастатической, местно-распространенной формы заболевания или в случае развития рецидивов используются альтернативные методы лечения, включающие химиотерапию, лучевую терапию. Целью данной публикации является изучение клинических и морфологических характеристик опухоли, оценка эффективности различных вариантов лечения, а также описание 2 клинических случаев МНЭО у детей раннего возраста.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare type of tumor with uncertain clinical behavior. The tumor commonly occurred in the head and neck region. Radical surgical resection is the standard of treatment, which is often associated with high risks of severe postoperative complications due to tumor localization. Alternative methods of treatment including chemotherapy/radiotherapy are used in metastatic, locally advanced and relapsed cases of MNTI. The aim of this study was to analyze clinical and morphological characteristics of the tumor, evaluate the effectiveness of various treatment options, and to describe two clinical cases of MNTI.

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The authors declare that there are no conflicts of interest present.