nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2019-6-3-94-102nodgo-534Research ArticleСЛУЧАЙ ИЗ ПРАКТИКИCASE STUDYФокальная нодулярная гиперплазия печени как позднее осложнение, возникающее после аутологичной трансплантации гемопоэтических стволовых клеток у детей с нейробластомой (клинический случай и обзор литературы)Focal nodular liver hyperplasia as a late complication that occurs after autologous hematopoietic stem cell transplantation in children with neuroblastoma (clinical case and literature review)СагоянГ. Б.SagoyanG. B.

Гарик Барисович Сагоян

врач-детский онколог отделения хирургии № 2 (опухолей торакоабдоминальной локализации)

115478, Москва, Каширское шоссе, 23

Pediatric Oncologist Department of Surgery No. 2 (Tumors of Thoracoabdominal Localization) Research

23 Kashirskoe Shosse, Moscow, 115478

sagoyan-garik@mail.ruhttps://orcid.org/0000-0002-3767-4477ШаманскаяТ. В.ShamanskayaT. V.

к.м.н., ученый секретарь Института онкологии, радиологии и ядерной медицины НМИЦ ДГОИ им. Дмитрия Рогачева

119991, Москва, Абрикосовский пер., 2

Cand. of Sci. (Med.), Academic Secretary of the Institute of Oncology, Radiology and Nuclear Medicine Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

2 Abrikosovsky per., Moscow, 119991

shamanskaya.tatyana@gmail.comhttps://orcid.org/0000-0002-3704-8783КачановД. Ю.KachanovD. Yu.

д.м.н., заведующий отделением клинической онкологии, заместитель директора Института онкологии, радиологии и ядерной медицины НМИЦ ДГОИ им. Дмитрия Рогачева, SPIN-код: 9878-5540

119991, Москва, Абрикосовский пер., 2

Dr. of Sci. (Med.), Head of the Department of Clinical Oncology and Department of Embryonic Tumor Research & Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

2 Abrikosovsky per., Moscow, 119991

Denis.Kachanov@fccmoscow.ruhttps://orcid.org/0000-0003-4751-5119ГалянТ. Н.GalyanT. N.

к.м.н., заведующая отделением рентгенодиагностики и компьютерной томографии РНЦХ им. академика Б.В. Петровского, SPIN-code: 6821-5834

241033, Брянск, просп. Станке Димитрова, 100

Cand. of Sci. (Med.), Head of the Department of Radiology and Computed Tomography Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia

100 Prosp. Stanke Dimitrova, Bryansk, 241033

galmedi05@gmail.comhttps://orcid.org/0000-0003-4205-5627ФилинА. В.FilinA. V.

д.м.н., заведующий отделением пересадки печени РНЦХ им. акад. Б.В. Петровского

241033, Брянск, просп. Станке Димитрова, 100

Dr. of Sci. (Med.), Head of Liver Transplant Department Russian Scientific Center of Surgery named after. Academician B.V. Petrovsky, Ministry of Health of Russia

100 Prosp. Stanke Dimitrova, Bryansk, 241033

docfilin@inbox.ruhttps://orcid.org/0000-0002-1732-324XРаковМ. А.RakovM. A.

заведующий отделением гематологии, онкологии и химиотерапии Брянской областной детской больницы

117997, Москва, ул. Саморы Машела, 1

Head of Department of Hematology, Oncology and Chemotherapy Bryansk Regional Children’s Hospital

1 Samory Mashela St., Moscow, 117997

drrakov@rambler.ruhttps://orcid.org/0000-0003-2348-221XФеоктистоваЕ. В.FeoktistovaE. V.

к.м.н., заведующая отделением ультразвуковой диагностики НМИЦ ДГОИ им. Дмитрия Рогачева

119991, Москва, Абрикосовский пер., 2

Cand. of Sci. (Med.), Head of Department of Ultrasound Diagnostics Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

2 Abrikosovsky per., Moscow, 119991

9433672@mail.ruhttps://orcid.org/0000-0002-6158-2222ЛикарьЮ. Н.LikarYu. N.

д.м.н., заведующий отделением радиоизотопной диагностики и позитронно-эмиссионной томографии НМИЦ ДГОИим. Дмитрия Рогачева

119991, Москва, Абрикосовский пер., 2

Dr. of Sci. (Med.), Head of the Department of Radioisotope Diagnostics and Positron Emission Tomography Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

2 Abrikosovsky per., Moscow, 119991

Yury.Likar@fccho-moscow.ruhttps://orcid.org/0000-0001-6131-1783ВарфоломееваС. Р.VarfolomeevaS. R.

д.м.н., профессор, заместитель директора по научной и лечебной работе – директор НИИ детской онкологии и гематологии аппарата управления НМИЦ онкологии им. Н.Н. Блохина, исполнительный директор РОО НОДГО

115478, Москва, Каширское шоссе, 23

Dr. of Sci. (Med.), Professor, Deputy Director for Research and Clinical Work – Director of the Research Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Executive Director of Regional Public Organization National Society of Pediatric Hematologists and Oncologists

23 Kashirskoe Shosse, Moscow, 115478

clinoncology@gmail.comНИИ детской онкологии и гематологии ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияResearch Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of RussiaRussian FederationФГБНУ «Российский научный центр хирургии им. акад. Б.В. Петровского» Минздрава РоссииРоссияRussian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of RussiaRussian FederationГБУЗ «Брянская областная детская больница»РоссияBryansk Regional Children’s HospitalRussian FederationФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation2019240920196394102Copyright © Сагоян Г.Б., Шаманская Т.В., Качанов Д.Ю., Галян Т.Н., Филин А.В., Раков М.А., Феоктистова Е.В., Ликарь Ю.Н., Варфоломеева С.Р., 20192019Сагоян Г.Б., Шаманская Т.В., Качанов Д.Ю., Галян Т.Н., Филин А.В., Раков М.А., Феоктистова Е.В., Ликарь Ю.Н., Варфоломеева С.Р.Sagoyan G.B., Shamanskaya T.V., Kachanov D.Y., Galyan T.N., Filin A.V., Rakov M.A., Feoktistova E.V., Likar Y.N., Varfolomeeva S.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/534

Фокальная нодулярная гиперплазия (ФНГ) – регенеративное объемное образование печени, которое может возникать как следствие реакции гепатоцитов на локальные сосудистые нарушения кровообращения и являться одним из поздних осложнений у больных, получивших высокодозную химиотерапию с последующей трансплантацией гемопоэтических стволовых клеток. В данной статье представлено описание 2 клинических случаев развития ФНГ печени у пациентов с нейробластомой группы высокого риска, выявленной на поздних сроках от окончания специфического лечения. Возможной причиной развития ФНГ печени у данных пациентов могло быть использование алкилирующих препаратов (ифосфамид, треосульфан, бусульфан, мелфалан).

Focal nodular hyperplasia (FNH) is a regenerative volumetric liver formation that can occur as a result of the reaction of hepatocytes to local vascular circulatory disorders and is one of the late complications in patients who received high-dose chemotherapy followed by hematopoietic stem cell transplantation. This article presents a description of two clinical cases of development of liver FNH in patients with high-risk neuroblastoma identified in the late stages from the end of specific treatment. A possible reason for the development of liver FNH in these patients could be the use of alkylating drugs (ifosfamide, threosulfan, busulfan, melphalan).

нейробластомадетиаутологичная трансплантация гемопоэтических стволовых клетокпоздние осложненияфокальная нодулярная гиперплазия печениneuroblastomachildrenautologous hematopoietic stem cell transplantationlate complicationsfocal nodular liver hyperplasiaReferencesMaris J.M. Recent advances in neuroblastoma. N Engl J Med 2010;362(23):2202–11. doi: 10.1056/NEJMra0804577.Maris J.M. Recent advances in neuroblastoma. N Engl J Med 2010;362(23):2202–11. doi: 10.1056/NEJMra0804577.Goodman M.S., Gurney J.G., Smith M.A., Olshan A.F. Sympathetic nervous system tumors. In: Ries L.A.G., Smith M.A., Gurney J.G., Linet M., Tamra T., Young J.L. Jr, Bunin G.R., eds. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER Program. Bethesda, MD, 1999. Pp. 65–72.Goodman M.S., Gurney J.G., Smith M.A., Olshan A.F. Sympathetic nervous system tumors. In: Ries L.A.G., Smith M.A., Gurney J.G., Linet M., Tamra T., Young J.L. Jr, Bunin G.R., eds. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER Program. Bethesda, MD, 1999. Pp. 65–72.Spix C., Pastore G., Sankila R., Stiller C.A., Steliarova-Foucher E. Neuroblastoma incidence and survival in European children (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006;42(13):2081–91. doi: 10.1016/j.ejca.2006.05.008.Spix C., Pastore G., Sankila R., Stiller C.A., Steliarova-Foucher E. Neuroblastoma incidence and survival in European children (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006;42(13):2081–91. doi: 10.1016/j.ejca.2006.05.008.Matthay K.K., Maris J.M., Schleiermacher G., Nakagawara A., Mackall C.L., Diller L., Weiss W.A. Neuroblastoma. Nat Rev Dis Primers 2016;2:16078. doi: 10.1038/nrdp.2016.78.Matthay K.K., Maris J.M., Schleiermacher G., Nakagawara A., Mackall C.L., Diller L., Weiss W.A. Neuroblastoma. Nat Rev Dis Primers 2016;2:16078. doi: 10.1038/nrdp.2016.78.Matthay K.K., Villablanca J.G., Seeger R.C., Stram D.O., Harris R.E., Ramsay N.K., Swift P., Shimada H., Black C.T., Brodeur G.M., Gerbing R.B., Reynolds C.P. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. N Engl J Med 1999;341:1165–73. doi: 10.1056/NEJM199910143411601.Matthay K.K., Villablanca J.G., Seeger R.C., Stram D.O., Harris R.E., Ramsay N.K., Swift P., Shimada H., Black C.T., Brodeur G.M., Gerbing R.B., Reynolds C.P. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. N Engl J Med 1999;341:1165–73. doi: 10.1056/NEJM199910143411601.Laino M.E., Monti S., Klimstra D.S., Tang L.H., Mannelli L. Treatment-related Focal Nodular Hyperplasia Mimicking Liver Metastases. J Pediatr Hematol Oncol 2019;41(2):138–9. doi: 10.1097/ MPH.0000000000001362.Laino M.E., Monti S., Klimstra D.S., Tang L.H., Mannelli L. Treatment-related Focal Nodular Hyperplasia Mimicking Liver Metastases. J Pediatr Hematol Oncol 2019;41(2):138–9. doi: 10.1097/ MPH.0000000000001362.Bouyn C.I., Leclere J., Raimondo G., Le Pointe H.D., Couanet D., Valteau-Couanet D., Hartmann O. Hepatic focal nodular hyperplasia in children previously treated for a solid tumor. Incidence, risk factors, and outcome. Cancer 2003;97:3107–13. doi: 10,1002/cncr.11452.Bouyn C.I., Leclere J., Raimondo G., Le Pointe H.D., Couanet D., Valteau-Couanet D., Hartmann O. Hepatic focal nodular hyperplasia in children previously treated for a solid tumor. Incidence, risk factors, and outcome. Cancer 2003;97:3107–13. doi: 10,1002/cncr.11452.Kumagai H., Masuda T., Oikawa H., Endo K., Takano T. Focal nodular hyperplasia of the liver: direct evidence of circulatory disturbances. J Gastroenterol Hepatol 2000;15:1344–7. PMID: 11129233.Kumagai H., Masuda T., Oikawa H., Endo K., Takano T. Focal nodular hyperplasia of the liver: direct evidence of circulatory disturbances. J Gastroenterol Hepatol 2000;15:1344–7. PMID: 11129233.International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983–93. PMID: 7657307.International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983–93. PMID: 7657307.Franchi-Abella S., Branchereau S. Benign hepatocellular tumors in children: focal nodular hyperplasia and hepatocellular adenoma. Int J Hepatol 2013; 2013:215064. doi: 10.1155/2013/215064.Franchi-Abella S., Branchereau S. Benign hepatocellular tumors in children: focal nodular hyperplasia and hepatocellular adenoma. Int J Hepatol 2013; 2013:215064. doi: 10.1155/2013/215064.Stocker J.T., Kamal G.I. Focal nodular hyperplasia of the liver: a study of 21 pediatric cases Cancer 1981;48(2):336–45. PMID: 7237404.Stocker J.T., Kamal G.I. Focal nodular hyperplasia of the liver: a study of 21 pediatric cases Cancer 1981;48(2):336–45. PMID: 7237404.Pillon M., Carucci N.S., Mainardi C., Carraro E., Zuliani M., Chemello L., Calore E., Tumino M., Varotto S., Toffolutti T., Destro R., Gazzola M. V., Alaggio R., Basso G., Messina C. Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children. Bone Marrow Transplant 2015;50(3):414–9. doi: 10.1038/bmt.2014.276.Pillon M., Carucci N.S., Mainardi C., Carraro E., Zuliani M., Chemello L., Calore E., Tumino M., Varotto S., Toffolutti T., Destro R., Gazzola M. V., Alaggio R., Basso G., Messina C. Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children. Bone Marrow Transplant 2015;50(3):414–9. doi: 10.1038/bmt.2014.276.Joyner B.L., Goyal R.K., Newman B., Levin T.L. Focal nodular hyperplasia of the liver: a sequela of tumor therapy. Pediatr Radiol 2005;35(12):1234–9. doi: 10.1007/s00247-005-1558-8.Joyner B.L., Goyal R.K., Newman B., Levin T.L. Focal nodular hyperplasia of the liver: a sequela of tumor therapy. Pediatr Radiol 2005;35(12):1234–9. doi: 10.1007/s00247-005-1558-8.Fan C.Q., Crawford J.M. Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). J Clin Exp Hepatol 2014;4(4):332–46. doi: 10.1016/j.jceh.2014.10.002.Fan C.Q., Crawford J.M. Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). J Clin Exp Hepatol 2014;4(4):332–46. doi: 10.1016/j.jceh.2014.10.002.Masetti R., Colecchia A., Rondelli R., Martoni A., Vendemini F., Biagi C., Prete A., Festi D., Lima M., Pession A. Benign hepatic nodular lesions after treatment for childhood cancer. J Pediatr Gastroenterol Nutr 2013;56(2):151–5. doi: 10.1097/MPG.0b013e31826f7660.Masetti R., Colecchia A., Rondelli R., Martoni A., Vendemini F., Biagi C., Prete A., Festi D., Lima M., Pession A. Benign hepatic nodular lesions after treatment for childhood cancer. J Pediatr Gastroenterol Nutr 2013;56(2):151–5. doi: 10.1097/MPG.0b013e31826f7660.Berthold F., Ernst A., Hero B., Klingebiel T., Kremens B., Schilling F. H., Simon T. Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation. Br J Cancer 2018;119(3):282–90. doi: 10.1038/s41416-018-0169-8.Berthold F., Ernst A., Hero B., Klingebiel T., Kremens B., Schilling F. H., Simon T. Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation. Br J Cancer 2018;119(3):282–90. doi: 10.1038/s41416-018-0169-8.Elzembely M.M., Dahlberg A.E., Pinto N., Leger K.J., Chow E.J., Park J.R., Carpenter P.A., Baker K.S. Late effects in high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell rescue. Pediatr Blood Cancer 2019;66(1):e27421. doi: 10.1002/pbc.27421.Elzembely M.M., Dahlberg A.E., Pinto N., Leger K.J., Chow E.J., Park J.R., Carpenter P.A., Baker K.S. Late effects in high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell rescue. Pediatr Blood Cancer 2019;66(1):e27421. doi: 10.1002/pbc.27421.Benz-Bohm G., Hero B., Gossmann A., Simon T., Körber F., Berthold F. Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma: how much diagnostic imaging is necessary? Eur J Radiol 2010;74(3):e1–5. doi: 10.1016/j.ejrad.2009.03.011.Benz-Bohm G., Hero B., Gossmann A., Simon T., Körber F., Berthold F. Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma: how much diagnostic imaging is necessary? Eur J Radiol 2010;74(3):e1–5. doi: 10.1016/j.ejrad.2009.03.011.Bartolotta T.V., Midiri M., Scialpi M., Sciarrino E., Galia M., Lagalla R. Focal nodular hyperplasia in normal and fatty liver: a qualitative and quantitative evaluation with contrast-enhanced ultrasound. Eur Radiol 2004;14:583–91. doi: 10.1007/s00330-003-2089-z.Bartolotta T.V., Midiri M., Scialpi M., Sciarrino E., Galia M., Lagalla R. Focal nodular hyperplasia in normal and fatty liver: a qualitative and quantitative evaluation with contrast-enhanced ultrasound. Eur Radiol 2004;14:583–91. doi: 10.1007/s00330-003-2089-z.Wang W., Chen L.D., Lu M.D., Liu G.J., Shen S.L., Xu Z.F., Xie X.Y., Wang Y., Zhou L.Y. Contrast-enchanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-encanced CT. Eur Radiol 2013;23(9):2546–54. doi: 10.1007/s00330-013-2849-3.Wang W., Chen L.D., Lu M.D., Liu G.J., Shen S.L., Xu Z.F., Xie X.Y., Wang Y., Zhou L.Y. Contrast-enchanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-encanced CT. Eur Radiol 2013;23(9):2546–54. doi: 10.1007/s00330-013-2849-3.Dill-Macky M.J., Burns P.N., Khalili K., Wilson S.R. Focal hepatic masses: enhancement patterns with SH U 508A and pulse-inversion US. Radiology 2002;222: 1:95–102. doi: 10.1148/radiol.2221010092.Dill-Macky M.J., Burns P.N., Khalili K., Wilson S.R. Focal hepatic masses: enhancement patterns with SH U 508A and pulse-inversion US. Radiology 2002;222: 1:95–102. doi: 10.1148/radiol.2221010092.Lencioni R., Cioni D., Bartolozzi C. Focal liver lesions, detection, characterization, ablation. Springer Verlag, 2005. ISBN: 3540644644.Lencioni R., Cioni D., Bartolozzi C. Focal liver lesions, detection, characterization, ablation. Springer Verlag, 2005. ISBN: 3540644644.Li A.-J., Zhou W.P., Wu M.C. Diagnosis and treatment of hepatic focal nodular hyperplasia: report of 114 cases. Zhonghua Wai Ke Za Zhi (Chinese J Surg) 2006;44(5):321–3. PMID: 16635391.Li A.-J., Zhou W.P., Wu M.C. Diagnosis and treatment of hepatic focal nodular hyperplasia: report of 114 cases. Zhonghua Wai Ke Za Zhi (Chinese J Surg) 2006;44(5):321–3. PMID: 16635391.Mortele K.J., Praet M., Van Vlierberghe H., Kunnen M., Ros P.R. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Am J Roentgenol 2000;175(3):687–92. doi: 10.2214/ajr.175.3.1750687.Mortele K.J., Praet M., Van Vlierberghe H., Kunnen M., Ros P.R. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Am J Roentgenol 2000;175(3):687–92. doi: 10.2214/ajr.175.3.1750687.Seale M.K., Catalano O.A., Saini S., Hahn P.F., Sahani D.V. Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics: a review publication of the Radiological Society of North America 2009;29(6):1725–48. doi: 10.1148/rg.296095515.Seale M.K., Catalano O.A., Saini S., Hahn P.F., Sahani D.V. Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics: a review publication of the Radiological Society of North America 2009;29(6):1725–48. doi: 10.1148/rg.296095515.Sharp S.E., Trout A.T., Weiss B.D., Gelfand M.J. MIBG in Neuroblastoma Diagnostic Imaging and Therapy. Radiographics 2016;36(1):258–78. doi: 10.1148/rg.2016150099.Sharp S.E., Trout A.T., Weiss B.D., Gelfand M.J. MIBG in Neuroblastoma Diagnostic Imaging and Therapy. Radiographics 2016;36(1):258–78. doi: 10.1148/rg.2016150099.Vik T.A., Pfluger T., Kadota R., Castel V., Tulchinsky M., Farto J.C., Heiba S., Serafini A., Tumeh S., Khutoryansky N., Jacobson A.F. (123) I-mIBG scintigraphy in patients with known or suspected neuroblastoma: Results from a prospective multicenter trial. Pediatr Blood Cancer 2009;52(7):784–90. doi: 10.1002/pbc.21932.Vik T.A., Pfluger T., Kadota R., Castel V., Tulchinsky M., Farto J.C., Heiba S., Serafini A., Tumeh S., Khutoryansky N., Jacobson A.F. (123) I-mIBG scintigraphy in patients with known or suspected neuroblastoma: Results from a prospective multicenter trial. Pediatr Blood Cancer 2009;52(7):784–90. doi: 10.1002/pbc.21932.Nakajo M., Shapiro B., Copp J., Kalff V., Gross M.D., Sisson J.C., Beierwaltes W.H. The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131] iodobenzylguanidine (I-131 MIBG) in man: evaluation by scintigraphy. J Nucl Med 1983;24(8):672–82. PMID: 6135764.Nakajo M., Shapiro B., Copp J., Kalff V., Gross M.D., Sisson J.C., Beierwaltes W.H. The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131] iodobenzylguanidine (I-131 MIBG) in man: evaluation by scintigraphy. J Nucl Med 1983;24(8):672–82. PMID: 6135764.Jacobsson H., Hellström P.M., Kogner P., Larsson S.A. Different concentrations of I-123 MIBG and In-111 pentetreotide in the two main liver lobes in children: persisting regional functional differences after birth? Clin Nucl Med 2007;32(1):24–8. doi: 10.1097/01.rlu.0000249592.95945.e4.Jacobsson H., Hellström P.M., Kogner P., Larsson S.A. Different concentrations of I-123 MIBG and In-111 pentetreotide in the two main liver lobes in children: persisting regional functional differences after birth? Clin Nucl Med 2007;32(1):24–8. doi: 10.1097/01.rlu.0000249592.95945.e4.Kulatunge C.R., Son H. False-positive 123I-MIBG scintigraphy due to multiple focal nodular hyperplasia. Clin Nucl Med 2013;38(12):976–8. doi: 10.1097 / RLU.0000000000000234.Kulatunge C.R., Son H. False-positive 123I-MIBG scintigraphy due to multiple focal nodular hyperplasia. Clin Nucl Med 2013;38(12):976–8. doi: 10.1097 / RLU.0000000000000234.

The authors declare that there are no conflicts of interest present.