nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2019-6-4-48-54nodgo-553Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESБелок CRABP1 как один из возможных факторов прогноза у детей с нейробластомой группы высокого рискаProtein CRABP1 as one of the possible prognosis factors in children with high-risk neuroblastomahttps://orcid.org/0000-0002-7297-5240СтрогановаА. М.StroganovaA. M.

Анна Михайловна Строганова - кандидат медицинских наук, заведующая молекулярно-биологической лабораторией отдела морфологической и молекулярно-генетической диагностики опухолей НИИ клинической онкологии им. акад. РАН и РАМН Н.Н. Трапезникова НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Cand. of Sci. (Med.), Head of the Molecular Biological Laboratory of the Department of Morphological and Molecular Genetic Diagnosis of Tumors of the N.N. Trapeznikov Research Institute of Clinical Oncology.

23 Kashirskoe Shosse, Moscow, 115478

stroganova_am@mail.ruhttps://orcid.org/0000-0002-1016-539XРубанскаяМ. В.RubanskayaM. V.

Кандидат медицинских наук, старший научный сотрудник 2-го хирургического отделения НИИ детской онкологии и гематологии НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Cand. of Sci. (Med.), Researcher and Pediatric Oncologist Department of Surgery No. 2 Research Institute of Pediatric Oncology and Hematology.

23 Kashirskoe Shosse, Moscow, 115478

marishvecova@yandex.ruhttps://orcid.org/0000-0003-0019-3765ЧемерисГ. Ю.ChemerisG. Yu.

Кандидат биологических наук, старший научный сотрудник патологоанатомического отделения отдела морфологической и молекулярно-генетической диагностики опухолей НИИ клинической онкологии им. акад. РАН и РАМН Н.Н. Трапезникова НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Cand. of Sci. (Biol.), Senior Researcher of the Pathology Department of the N.N. Trapeznikov Research Institute of Clinical Oncology.

23 Kashirskoe Shosse, Moscow, 115478

https://orcid.org/0000-0003-3315-0817ДранкоС. Л.DrankoS. L.

Врач-лабораторный генетик молекулярно-биологической лаборатории отдела морфологической и молекулярно-генетической диагностики опухолей НИИ клинической онкологии им. акад. РАН и РАМН Н.Н. Трапезникова НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Laboratory Geneticist of Molecular Biological Laboratory of the N.N. Trapeznikov Research Institute of Clinical Oncology.

23 Kashirskoe Shosse, Moscow, 115478

s.maykulova@mail.ruhttps://orcid.org/0000-0001-9660-923XКарселадзеА. И.KarseladzeA. I.

Доктор медицинских наук, ведущий научный сотрудник патологоанатомического отделения отдела морфологической и молекулярно-генетической диагностики опухолей НИИ клинической онкологии им. акад. РАН и РАМН Н.Н. Трапезникова НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Dr. of Sci. (Med.), Leading Researcher ofthe Pathology Department of the N.N. Trapeznikov Research Institute ofClinical Oncology.

23 Kashirskoe Shosse, Moscow, 115478

vacutuchuni@mail.ruhttps://orcid.org/0000-0002-7846-3473СагоянГ. Б.SagoyanG. B.

Врач-детский онколог НИИ детской онкологии и гематологии НМИЦ онкологии им. Н.Н. Блохина, аспирант НМИЦ ДГОИ им. Дмитрия Рогачева, SPIN-код: 6304-0159.

115478, Москва, Каширское шоссе, 23; 117997, Москва, ул. Саморы Машела, 1

Pediatric Oncologist Research Institute of Pediatric Oncology and Hematology of N.N. Blokhin NMRCO, Graduate Student Dmitry Rogachev NMRCPHOI, SPIN-code: 6304-0159

23 Kashirskoe Shosse, Moscow, 115478; 1 Samory Mashela St., Moscow, 117997

g.sagojan@ronc.ruhttps://orcid.org/0000-0001-7309-1650КазанцевА. П.KazantsevA. P.

Доктор медицинских наук, заведующий 2-м хирургическим отделением НИИ детской онкологии и гематологии НМИЦ онкологии им. Н.Н. Блохина.

115478, Москва, Каширское шоссе, 23

Dr. of Sci. (Med.), Head of the Department of Surgery No. 2 Research Institute of Pediatric Oncology and Hematology.

23 Kashirskoe Shosse, Moscow, 115478

oncoanat@mail.ruФГБУ «НМИЦонкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of RussiaRussian FederationФГБУ «НМИЦонкологии им. Н.Н. Блохина» Минздрава России; ФГБУ«НМИЦДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian Federation201922012020644854Copyright © Строганова А.М., Рубанская М.В., Чемерис Г.Ю., Дранко С.Л., Карселадзе А.И., Сагоян Г.Б., Казанцев А.П., 20202020Строганова А.М., Рубанская М.В., Чемерис Г.Ю., Дранко С.Л., Карселадзе А.И., Сагоян Г.Б., Казанцев А.П.Stroganova A.M., Rubanskaya M.V., Chemeris G.Y., Dranko S.L., Karseladze A.I., Sagoyan G.B., Kazantsev A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/553

Нейробластома (НБ) — наиболее распространенная экстракраниальная солидная опухоль детского возраста, составляющая 6—10 % всех злокачественных новообразований у детей. Одной из принципиально важных проблем для клинициста является стратификация группы риска и определение тактики лечения пациентов с НБ. В настоящей работе нами были проведены исследования зависимости экспрессии белка CRABP1 в первичном очаге и метастазах опухоли от типа генетических нарушений (амплификация гена MYCN, делеция локуса 11q23) и эффекта проведенной терапии у пациентов с НБ.

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood, accounting for 6—10 % of all malignant neoplasms in children. One of the fundamentally important problems for the clinician is the stratification of the risk group and the definition of treatment tactics for patients with NB. In this work, we studied the dependence of the expression of CRABP1 protein in the primary focus and tumor metastases on the type of genetic disorders (amplification of the MYCN gene, deletion of the 11q23 locus) and the effect of the therapy in patients with NB.

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The authors declare that there are no conflicts of interest present.