nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2020-7-3-78-85nodgo-628Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSТаргетные препараты в лечении острых миелоидных лейкозов у детейTargeted drugs in the treatment of acute myeloid leukemia in childrenhttps://orcid.org/0000-0003-3880-4402СерегинГ. З.SereginG. Z.

Врач-ординатор НИИ детской онкологии и гематологии

115478, Москва, Каширское шоссе, 23

Clinical Resident Research Center Of Pediatric Oncology and Hematology

23 Kashirskoe Shosse, Moscow, 115478

george.seregin@inbox.ruhttps://orcid.org/0000-0001-9095-1771ЛифшицА. В.LifshitsA. V.

Студентка 6-го курса педиатрического факультета

117997, Москва, ул. Островитянова, 1

6th year Student

1 Ostrovityanova St., Moscow, 117997

lifshitsanna@gmail.comhttps://orcid.org/0000-0002-1469-2365ВалиевТ. Т.ValievT. T.

Тимур Теймуразович Валиев, доктор медицинских наук, заведующий детским отделением химиотерапии гемобластозов отдела гематологии и трансплантации костного мозга НМИЦ онкологии им. Н.Н. Блохина, профессор кафедры детской онкологии РМАНПО

115478, Москва, Каширское шоссе, 23, 

125993, Москва, ул. Баррикадная, 2/1, стр. 1

Dr. of Sci. (Med.), Head of the Children’s Department of Hemoblastosis Chemotherapy of the Department of Hematology and Bone Marrow Transplantation of N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Professor at the Department of Pediatric Oncology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

23 Kashirskoe Shosse, Moscow, 115478, 

Bld. 1, 2/1 Barrikadnaya St., Moscow, 125993

timurvaliev@mail.ruФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of RussiaRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian FederationФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of RussiaRussian Federation202020092020737885Copyright © Серегин Г.З., Лифшиц А.В., Валиев Т.Т., 20202020Серегин Г.З., Лифшиц А.В., Валиев Т.Т.Seregin G.Z., Lifshits A.V., Valiev T.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/628

Возможности современной полихимиотерапии острых миелоидных лейкозов (ОМЛ) достигли своего предела, позволив получить общую выживаемость у 70 % больных. Дальнейшая эскалация химиотерапевтических режимов невозможна, поскольку сопряжена с крайне высокой токсичностью и риском развития жизнеугрожающих осложнений. Совершенствование программного лечения ОМЛ сопряжено с клиническим использованием достижений молекулярной биологии, иммунологии и цитогенетики опухолевой клетки. Исследования в области фундаментальной онкологии позволили выявить ключевые этапы лейкозогенеза и определить таргетные (молекулярно-направленные) пути воздействия в лечении ОМЛ.

The recent chemotherapeutic approaches to acute myeloid leukemia (AML) management reached the limits, achieving overall survival rate of approximately 70 %. An intensification of chemotherapeutic regimens is barely possible due to high level of toxicity and risk of lifethreatening complications. The modernization of program therapy of AML involves the clinical application of achievements in molecular biology, immunology and cytogenetic of the tumor cell. The researches in fundamental oncology revealed the phases of leukemogenesis and defined selective ways of targeted therapy in the treatment of AML.

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The authors declare that there are no conflicts of interest present.