nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”nodgo-689Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSПервичные лимфомы центральной нервной системы у детей и подростковPrimary central nervous system lymphomas in children and adolescentshttps://orcid.org/0000-0003-4999-5195ПавловаТ. Ю.PavlovaT. Yu.

врач-детский онколог детского отделения химиотерапии гемобластозов отдела гематологии и трансплантации костного мозга,

115478, Москва, Каширское шоссе, 23

Pediatric Oncologist Children’s Department of Hemoblastosis Chemotherapy of the Department of  Hematology and Bone Marrow Transplantation of Research Institute of Pediatric Oncology and Hematology,

23 Kashirskoe shosse, Moscow, 115478

md.pavlovaty@mail.ruhttps://orcid.org/0000-0002-1469-2365ВалиевТ. Т.ValievT. T.

д.м.н., заведующий детским отделением химиотерапии гемобластозов отдела гематологии и трансплантации костного мозга,

115478, Москва, Каширское шоссе, 23

Dr. of Sci. (Med.), Head of the Children’s Department of Hemoblastosis Chemotherapy of the Department of Hematology and Bone Marrow Transplantation of Research Institute of Pediatric Oncology and Hematology,

23 Kashirskoe shosse, Moscow, 115478

 

timurvaliev@mail.ruФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of RussiaRussian Federation202107042021814349Copyright © Павлова Т.Ю., Валиев Т.Т., 20212021Павлова Т.Ю., Валиев Т.Т.Pavlova T.Y., Valiev T.T.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/689

Первичные лимфомы центральной нервной системы (ПЛЦНС) являются очень редким и одним из самых агрессивных вариантов экстранодальных неходжкинских лимфом (НХЛ). ПЛЦНС составляют от 4 до 7 % злокачественных опухолей центральной нервной системы у взрослых, а их истинная частота у детей неизвестна. В последние несколько десятилетий встречаемость ПЛЦНС растет, что, возможно, связано с увеличением числа лиц с первичными и вторичными иммунодефицитами, хотя ПЛЦНС диагностируются и у лиц без иммунодефицитных состояний. В связи с редкой частотой встречаемости ПЛЦНС у детей и подростков клинико-морфоиммунологические особенности данного экстранодального варианта НХЛ нуждаются в обобщении и систематизации. Не менее актуальной проблемой является выбор тактики терапии ПЛЦНС в педиатрии. В настоящем обзоре представлен мировой и отечественный опыт диагностики и лечения ПЛЦНС у детей и подростков. 

Primary central nervous system lymphomas (PCNSL) are very rare and one of the most aggressive variants of extranodal nonHodgkin’s lymphomas (NHL). PCNSL comprise from 4 to 7 % of malignant tumors of the central nervous system in adults, and their true frequency in children is unknown. In the last few decades, the frequency of PCNSL has been increasing, possibly due to an increase the number of people with primary and secondary immunodeficiencies, although PCNSL are also diagnosed in people without an immunodeficiency condition. Due to the rare occurrence of PCNSL in children and adolescents, the clinical and morphoimmunological features of this extranodal variant of NHL need to be generalized and systematized. No less important problem is the choice of therapeutic tactics for PCNSL therapy in children. Current review presents the world and domestic experience in the diagnosis and treatment of pediatric and adolescent PCNSL. 

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The authors declare that there are no conflicts of interest present.