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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/2311-1267-2015-1-61-65</article-id><article-id custom-type="elpub" pub-id-type="custom">nodgo-80</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group></article-categories><title-group><article-title>Педиатрические тромбозы: применение далтепарина натрия для лечения и профилактики</article-title><trans-title-group xml:lang="en"><trans-title>Pediatric thrombosis: application of dalteparin for treatment and prevention</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свирин</surname><given-names>Павел Вячеславович</given-names></name><name name-style="western" xml:lang="en"><surname>Svirin</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 119049, Москва, 4-й Добрынинский пер., 1/9;</p><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1/9 4 th Dobryninskiy Per., Moscow, 119049, Russia;</p><p>1 Ostrovityanova St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">pavel_svirin@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларина</surname><given-names>Л. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Larina</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1 Ostrovityanova St., Moscow, 117997, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жарков</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zharkov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117198, Москва, ул. Саморы Машела, 1</p></bio><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117198, Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казанкова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazankova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 119049, Москва, 4-й Добрынинский пер., 1/9</p></bio><bio xml:lang="en"><p>1/9 4 th Dobryninskiy Per., Moscow, 119049, Russia</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 119049, Москва, 4-й Добрынинский пер., 1/9</p></bio><bio xml:lang="en"><p>1/9 4 th Dobryninskiy Per., Moscow, 119049, Russia</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лаврентьева</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lavrentyeva</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 119049, Москва, 4-й Добрынинский пер., 1/9</p></bio><bio xml:lang="en"><p>1/9 4 th Dobryninskiy Per., Moscow, 119049, Russia</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Морозовская детская городская клиническая больница»; &#13;
ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Morozov Children's Hospital; &#13;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «Морозовская детская городская клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Morozov Children, s Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>05</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><fpage>61</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Свирин П.В., Ларина Л.Е., Жарков П.А., Казанкова А.А., Петров В.Ю., Лаврентьева И.Н., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Свирин П.В., Ларина Л.Е., Жарков П.А., Казанкова А.А., Петров В.Ю., Лаврентьева И.Н.</copyright-holder><copyright-holder xml:lang="en">Svirin P.V., Larina L.E., Zharkov P.A., Kazankova A.A., Petrov V.Y., Lavrentyeva I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/80">https://journal.nodgo.org/jour/article/view/80</self-uri><abstract><p>Приведен анализ результатов применения далтепарина натрия (препарата Фрагмин®) для профилактики и лечения тромбозов различной локализации у 62 детей. Оценены средние относительные дозы в зависимости от возраста пациентов, эффективность применения и безопасность препарата; необходимость индивидуального контролируемого подбора дозы.</p></abstract><trans-abstract xml:lang="en"><p>The analysis of the results of dalteparin sodium (Fragmin®) application for the prevention and treatment of thrombosis of various biodisposition in 62 children has been given. The average relative dose depending on the age of the patient, the effectiveness of application and the drug, s safety; the need to select individually controlled doses has been evaluated.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбоз</kwd><kwd>низкомолекулярные гепарины</kwd><kwd>далтепарин натрия</kwd><kwd>Фрагмин®</kwd><kwd>нефракционированный гепарин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombosis</kwd><kwd>low-molecular heparins</kwd><kwd>dalteparin sodium</kwd><kwd>Fragmin®</kwd><kwd>unfractionated heparin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher T. Four Cases of Primary Thrombosis of Cerebral Veins and Sinuses in Children. Br Med J 1901;2(2114):9–12.</mixed-citation><mixed-citation xml:lang="en">Fisher T. Four Cases of Primary Thrombosis of Cerebral Veins and Sinuses in Children. Br Med J 1901;2(2114):9–12.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost 1995;74(1):415–25.</mixed-citation><mixed-citation xml:lang="en">Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost 1995;74(1):415–25.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Andrew M., Vegh P., Johnston M. et al. Maturation of the hemostatic system during childhood. Blood 1992;80(8):1998–2005.</mixed-citation><mixed-citation xml:lang="en">Andrew M., Vegh P., Johnston M. et al. Maturation of the hemostatic system during childhood. Blood 1992;80(8):1998–2005.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Nowak-Gottl U., Kosch A., Schlegel N. Thromboembolism in newborns, infants and children. Thromb Haemost 2001;86(1):464–74.</mixed-citation><mixed-citation xml:lang="en">Nowak-Gottl U., Kosch A., Schlegel N. Thromboembolism in newborns, infants and children. Thromb Haemost 2001;86(1):464–74.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Nowak-Gottl U., Kurnik K., Krumpel A., Stoll M. Thrombophilia in the young. Hamostaseologie 2008;28(1–2):16–20.</mixed-citation><mixed-citation xml:lang="en">Nowak-Gottl U., Kurnik K., Krumpel A., Stoll M. Thrombophilia in the young. Hamostaseologie 2008;28(1–2):16–20.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Monagle P., Chan A.K., Goldenberg N.A. et al. Antithrombotic Therapy in Neonates and Children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141: e737S–e801.</mixed-citation><mixed-citation xml:lang="en">Monagle P., Chan A.K., Goldenberg N.A. et al. Antithrombotic Therapy in Neonates and Children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141: e737S–e801.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bidlingmaier С., Kenet G., Kurnik K. et al. Safety and efficacy of low molecular weight heparins in children: a systematic review of the literature and meta-analysis of single-arm studies. Semin Thromb Hemost 2011;37(7):814–25.</mixed-citation><mixed-citation xml:lang="en">Bidlingmaier С., Kenet G., Kurnik K. et al. Safety and efficacy of low molecular weight heparins in children: a systematic review of the literature and meta-analysis of single-arm studies. Semin Thromb Hemost 2011;37(7):814–25.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pineo G.F., Hull R.D. Dalteparin sodium. Expert Opin Pharmacother 2001;2(8): 1325–37.</mixed-citation><mixed-citation xml:lang="en">Pineo G.F., Hull R.D. Dalteparin sodium. Expert Opin Pharmacother 2001;2(8): 1325–37.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Massicotte P., Adams M., Marzinotto V. et al. Low-molecular-weight heparin in pediatric patients with thrombotic disease: a dose finding study. J Pediatr 1996;128(3):313–8.</mixed-citation><mixed-citation xml:lang="en">Massicotte P., Adams M., Marzinotto V. et al. Low-molecular-weight heparin in pediatric patients with thrombotic disease: a dose finding study. J Pediatr 1996;128(3):313–8.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Punzalan R.C., Hillery C.A., Montgomery R.R. et al. Low-molecularweight heparin in thrombotic disease in children and adolescents. J Pediatr Hematol Oncol 2000;22(2):137–42.</mixed-citation><mixed-citation xml:lang="en">Punzalan R.C., Hillery C.A., Montgomery R.R. et al. Low-molecularweight heparin in thrombotic disease in children and adolescents. J Pediatr Hematol Oncol 2000;22(2):137–42.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Massicotte P., Julian J.A., Marzinotto V. et al. Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin-sodium) in pediatric patients. Thromb Res 2003;109(2–3):93–9.</mixed-citation><mixed-citation xml:lang="en">Massicotte P., Julian J.A., Marzinotto V. et al. Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin-sodium) in pediatric patients. Thromb Res 2003;109(2–3):93–9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Laporte S., Mismetti P., Piquet P. et al. Population pharmacokinetic of nadroparin calcium (Fraxiparine) in children hospitalised for open heart surgery. Eur J Pharm Sci 1999;8(2):119–25.</mixed-citation><mixed-citation xml:lang="en">Laporte S., Mismetti P., Piquet P. et al. Population pharmacokinetic of nadroparin calcium (Fraxiparine) in children hospitalised for open heart surgery. Eur J Pharm Sci 1999;8(2):119–25.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kuhle S., Massicotte P., Dinyari M. et al. Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events. Thromb Haemost 2005;94(6):1164–71.</mixed-citation><mixed-citation xml:lang="en">Kuhle S., Massicotte P., Dinyari M. et al. Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events. Thromb Haemost 2005;94(6):1164–71.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Trame M.N., Mitchell L., Krumpel A. et al. Population pharmacokinetics of enoxaparin in infants, children and adolescents during secondary thromboembolic prophylaxis: a cohort study. J Thromb Haemost 2010;8(9):1950–8.</mixed-citation><mixed-citation xml:lang="en">Trame M.N., Mitchell L., Krumpel A. et al. Population pharmacokinetics of enoxaparin in infants, children and adolescents during secondary thromboembolic prophylaxis: a cohort study. J Thromb Haemost 2010;8(9):1950–8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">O'Brien S.H., Kulkarni R., Wallace A. et al. Multicenter dose-finding and efficacy and safety outcomes in neonates and children treated with dalteparin for acute venous thromboembolism. J Thromb Haemost 2014;12(11):1822–5.</mixed-citation><mixed-citation xml:lang="en">O'Brien S.H., Kulkarni R., Wallace A. et al. Multicenter dose-finding and efficacy and safety outcomes in neonates and children treated with dalteparin for acute venous thromboembolism. J Thromb Haemost 2014;12(11):1822–5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nohe N., Flemmer A., Rumler R. et al. The low molecular weight heparin dalteparin for prophylaxis and therapy of thrombosis in childhood: a report on 48 cases. Eur J Pediatr 1999;158(Suppl 3):134–9.</mixed-citation><mixed-citation xml:lang="en">Nohe N., Flemmer A., Rumler R. et al. The low molecular weight heparin dalteparin for prophylaxis and therapy of thrombosis in childhood: a report on 48 cases. Eur J Pediatr 1999;158(Suppl 3):134–9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Inamo Y., Saito K., Hasegawa M. et al. Effect of dalteparin, a low-molecular-weight heparin, as adjunctive therapy in patients with Kawasaki disease: a retrospective study. BMC Pediatr 2014;14:27.</mixed-citation><mixed-citation xml:lang="en">Inamo Y., Saito K., Hasegawa M. et al. Effect of dalteparin, a low-molecular-weight heparin, as adjunctive therapy in patients with Kawasaki disease: a retrospective study. BMC Pediatr 2014;14:27.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Goldenberg N.A., Jacobson L., Hathaway H. et al. Anti-Xa stability of diluted dalteparin for pediatric use. Ann Pharmacother 2008;42(4):511–5.</mixed-citation><mixed-citation xml:lang="en">Goldenberg N.A., Jacobson L., Hathaway H. et al. Anti-Xa stability of diluted dalteparin for pediatric use. Ann Pharmacother 2008;42(4):511–5.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
