nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.21682/2311-1267-2022-9-1-29-44nodgo-800Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSСпектр синдромов избыточного роста, связанных с мутацией PIK3CA. Обзор литературыA spectrum of overgrowth syndromes associated with the PIK3CA mutation. Literature reviewhttps://orcid.org/0000-0002-7846-3473СагоянГ. Б.SagoyanG. B.

Гарик Барисович Сагоян, научный сотрудник, врач-детский онколог детского онкологического отделения хирургических методов лечения с проведением химиотерапии № 2 (опухолей торакоабдоминальной локализации) НИИ детской онкологии и гематологии, SPIN-код: 6304-0159

Москва

Researcher, Pediatric Oncologist of Pediatric Oncology Department of Surgical Methods of Treatment with Chemotherapy No. 2 (Tumors of Thoracoabdominal Localization) of Research Institute of Pediatric Oncology and Hematology, SPIN-code: 6304-0159

Moscow

sagoyan-garik@mail.ruhttps://orcid.org/0000-0002-8552-7682КлецкаяИ. С.KletskayaI. S.

врач-патологоанатом патологоанатомического отделения

Москва

Pathologist Pathology Department at Russian Children’s Clinical Hospital

Moscow

ikletskaya@gmail.comhttps://orcid.org/0000-0003-4529-7891ИмянитовЕ. Н.ImyanitovE. N.

член-корр. РАН, д.м.н., профессор, руководитель научного отдела биологии опухолевого роста и лаборатории молекулярной онкологии, SPIN-код: 1909-7323

Санкт-Петербург

Corresponding Member of RAS, Dr. of Sci. (Med.), Professor, Head of the Research Department of Biology of Tumor Growth and the Laboratory of Molecular Oncology, SPIN-code: 1909-7323

Saint Petersburg

evgeny@imyanitov.spb.ruhttps://orcid.org/0000-0003-0652-6049МарееваЮ. М.MareevaYu. M.

врач-детский онколог консультативного отделения

Москва

Pediatric Oncologist of Advisory Department

Moscow

7261610@mail.ruhttps://orcid.org/0000-0002-9054-5068ЖуковН. В.ZhukovN. V.

д.м.н., профессор, руководитель отдела мультидисциплинарной онкологии, SPIN-код: 8151-9305, ResearcherID: I-3833-2018

Москва

Dr. of Sci. (Med.), Professor, Head of Multidisciplinary Oncology Department, ResearcherID: I-3833-2018, SPIN-code: 8151-9305

Moscow

1cancerdoctor1@gmail.comhttps://orcid.org/0000-0001-7944-8438ХагуровР. А.KhagurovR. A.

к.м.н., врач-детский хирург отделения микрохирургии

Москва

Surgeon of the Department of Reconstructive Microsurgery

Moscow

dr.khagurov@gmail.comhttps://orcid.org/0000-0002-5489-1879СулеймановаА. М.SuleymanovaA. M.

научный сотрудник, врач-детский онколог детского онкологического отделения хирургических методов лечения с проведением химиотерапии № 2 (опухолей торакоабдоминальной локализации) НИИ детской онкологии и гематологии

Москва

Researcher, Pediatric Oncologist of Pediatric Oncology Department of Surgical Methods of Treatment with Chemotherapy No. 2 (Tumors of Thoracoabdominal Localization) of Research Institute of Pediatric Oncology and Hematology

Moscow

aminasuleymanova313@gmail.comНМИЦ онкологии им. Н.Н. БлохинаРоссияN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaRussian FederationРДКБ РНИМУ им. Н.И. ПироговаРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian FederationНМИЦ онкологии им. Н.Н. ПетроваРоссияN.N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaRussian FederationНМИЦ ДГОИ им. Дмитрия РогачеваРоссияDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaRussian FederationДГКБ им. Н.Ф. ФилатоваРоссияN.F. Filatov Children’s City Clinical Hospital, Moscow Department of HealthRussian Federation202230042022912944Copyright © Сагоян Г.Б., Клецкая И.С., Имянитов Е.Н., Мареева Ю.М., Жуков Н.В., Хагуров Р.А., Сулейманова А.М., 20222022Сагоян Г.Б., Клецкая И.С., Имянитов Е.Н., Мареева Ю.М., Жуков Н.В., Хагуров Р.А., Сулейманова А.М.Sagoyan G.B., Kletskaya I.S., Imyanitov E.N., Mareeva Y.M., Zhukov N.V., Khagurov R.A., Suleymanova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/800

Спектр синдромов избыточного роста, связанных с мутацией PIK3CA (PIK3CA-Related Overgrowth Spectrum, PROS), – термин, объединяющий редкие заболевания, которые характеризуются пороками развития и чрезмерным разрастанием тканей. Эти нарушения вызваны соматическими мутациями в гене PIK3CA, произошедшими на этапе эмбриогенеза. В статье рассмотрены патогенез, клиническая картина, диагностика и лечение данного спектра синдромов.

В работе часть использованных иллюстраций заимствована, права авторов учтены и не нарушены. Заимствование разрешено журналами, где были опубликованы статьи.

PIK3CA-Related Overgrowth Spectrum (PROS) refers to rare syndromes, which are characterized by malformations and excessive tissue growth and caused by somatic mutations in the PIK3CA gene occurring during embryogenesis. This article discusses the pathogenesis, clinical picture, diagnosis and treatment of these syndromes.

Some of the illustrations used in this article are copied from other resources, the rights of the authors are respected and not violated. The appropriate permissions from the journals have been obtained.

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The authors declare that there are no conflicts of interest present.