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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nodgo</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал детской гематологии и онкологии (РЖДГиО)</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Pediatric Hematology and Oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-1267</issn><issn pub-type="epub">2413-5496</issn><publisher><publisher-name>LTD “Graphica”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21682/2311-1267-2022-9-3-99-106</article-id><article-id custom-type="elpub" pub-id-type="custom">nodgo-864</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Клинический случай длительного персистирования SARS-CoV-2 у младенца с врожденным острым миелоидным лейкозом</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of long-term persistence of SARS-CoV-2 in infant with congenital acute myeloid leukemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0060-4168</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заслуженный врач РФ, главный внештатный специалист-неонатолог Минздрава России, ректор.</p><p>SPIN-код: 4437-9626</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Chief Freelance Specialist Neonatologist of the Ministry of Health of Russia, Rector. SPIN-code: 4437-9626</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">doivanov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1462-6907</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондратьев</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondratiev</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Глеб Валентинович Кондратьев, ассистент кафедры онкологии, детской онкологии и лучевой терапии, врач-детский онколог.</p><p>SPIN-код: 9092-3185</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Assistant Department of Oncology, Pediatric Oncology and Radiation Therapy, Pediatric Oncologist. SPIN-code: 9092-3185</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">spbgvk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4744-0882</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельников</surname><given-names>М. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnikov</surname><given-names>M. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент 5-го курса педиатрического факультета, лаборант кафедры онкологии, детской онкологии и лучевой терапии</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>5th year Student of Pediatrics Faculty, Laboratory Assistant Department of Oncology, Pediatric Oncology and Radiation Therapy</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">melmakse@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1351-1910</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баннова</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Bannova</surname><given-names>S. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры инфекционных заболеваний у детей им. проф. М.Г. Данилевича.</p><p>SPIN-код: 9654-9386</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Associate Professor Department of Infectious Diseases in Children named after professor M.G. Danilevich. SPIN-code: 9654-9386</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">detinfection@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0390-8498</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулева</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuleva</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая кафедрой онкологии, детской онкологии и лучевой терапии; заведующая детским онкологическим отделением, ведущий научный сотрудник научного отдела инновационных методов терапевтической онкологии и реабилитации, профессор учебно-методического отдела.</p><p>SPIN-код: 3441-4820</p><p>194100, Санкт-Петербург, ул. Литовская, 2197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Head of the Department of Oncology, Pediatric Oncology and Radiation Therapy; Head of Pediatric Oncology Department, Leading Researcher of the Research Department of Innovative Therapeutic Oncology and Rehabilitation Methods, Professor of the Training and Methodology Department. SPIN-code: 3441-4820</p><p>2 Litovskaya St., S.-Petersburg, 19410068 Leningradskaya St., Pesochny, S.-Petersburg, 197758</p></bio><email xlink:type="simple">kulevadoc@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8623-4574</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петренко</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrenko</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., проректор по национальным проектам и лечебной работе.</p><p>SPIN-код: 1644-1394</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Vice-Rector for National Projects and Clinical Work. SPIN-code: 1644-1394</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">alez1964@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4068-1731</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимченко</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Timchenko</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующий кафедрой инфекционных заболеваний у детей им. проф. М.Г. Данилевича.</p><p>SPIN-код: 8594-0751</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Head of the Department of Infectious Diseases in Children named after professor M.G. Danilevich. SPIN-code: 8594-0751</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">timchenko220853@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2776-6239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резник</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Reznik</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., главный врач клиники.</p><p>SPIN-код: 9761-6624</p><p>194100, Санкт-Петербург, ул. Литовская, 2</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Chief Physician of the Clinic. SPIN-code: 9761-6624</p><p>2 Litovskaya St., S.-Petersburg, 194100</p></bio><email xlink:type="simple">klinika.spb@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia; N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>09</day><month>11</month><year>2022</year></pub-date><volume>9</volume><issue>3</issue><fpage>99</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванов Д.О., Кондратьев Г.В., Мельников М.Е., Баннова С.Л., Кулева С.А., Петренко Ю.В., Тимченко В.Н., Резник В.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Иванов Д.О., Кондратьев Г.В., Мельников М.Е., Баннова С.Л., Кулева С.А., Петренко Ю.В., Тимченко В.Н., Резник В.А.</copyright-holder><copyright-holder xml:lang="en">Ivanov D.O., Kondratiev G.V., Melnikov M.E., Bannova S.L., Kuleva S.A., Petrenko Y.V., Timchenko V.N., Reznik V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nodgo.org/jour/article/view/864">https://journal.nodgo.org/jour/article/view/864</self-uri><abstract><p>По имеющимся данным, дети менее подвержены развитию тяжелого течения новой коронавирусной инфекции и чаще переносят данную инфекцию в бессимптомной и легкой форме. Сообщается о повышенном риске развития тяжелых состояний у детей первого года жизни, в то же время, согласно литературным данным, течение инфекции у детей, получающих противоопухолевую и иммуносупрессивную терапию, протекает легче по сравнению с детьми с другими сопутствующими патологиями. В данной работе представлен уникальный клинический случай и литературный обзор сочетанной патологии COVID-19-пневмонии с крайне редкой формой врожденного острого миелоидного лейкоза у младенца, в котором представлено описание длительного персистирования инфекции, динамики изменения клинических показателей и состояния ребенка на фоне лейкоза, результаты исследований костного мозга, а также опыт применения донорской плазмы с антителами к SARS-CoV-2.</p></abstract><trans-abstract xml:lang="en"><p>According to the available data, children are less susceptible for developing a severe course of COVID-19 and commonly have mild or asymptomatic course of infection. It is reported about an increased risk of having more severe course in infants, at the same time, according to the literature data, the course in children receiving antineoplastic and immunosuppressive therapy is milder in comparison with other concomitant pathologies. This article presents the unique clinical case and the literature review of combined COVID-19-pneumonia and extremely rare congenital myeloid leukemia in the infant with the description of long-term infection persistence, changes in clinical data in dynamics, bone marrow test results and the experience of using donor plasma with antibodies to SARS-CoV-2.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>пневмония</kwd><kwd>острый миелоидный лейкоз</kwd><kwd>врожденный лейкоз</kwd><kwd>реконвалесцентная плазма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>novel coronavirus infection</kwd><kwd>pneumonia</kwd><kwd>acute myeloid leukemia</kwd><kwd>congenital leukemia</kwd><kwd>convalescent plasma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Усков А.Н., Лобзин Ю.В., Рычкова С.В., Бабаченко И.В., Федоров В.В., Улуханова Л.У., Починяева Л.М. 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