nodgoРоссийский журнал детской гематологии и онкологии (РЖДГиО)Russian Journal of Pediatric Hematology and Oncology2311-12672413-5496LTD “Graphica”10.17650/2311-1267-2015-1-96-100nodgo-89Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESТромбоз воротной вены у пациента со злокачественной рабдоидной опухолью печени (описание клинического случая)Portal vein thrombosis in a patient with a malignant rhabdoid tumor of the liver (Case report)НаумоваАлександра СергеевнаNaumovaA. S.

Россия, 117198, Москва, ул. Саморы Машела, 1

1 Samory Mashela St., Moscow, 117198, Russia

alex.naumova@gmail.comФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава РоссииРоссияFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaRussian Federation2015230520152196100Copyright © Наумова А.С., 20152015Наумова А.С.Naumova A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nodgo.org/jour/article/view/89

В работе представлен клинический случай тромбоза портальной вены у ребенка со злокачественной рабдоидной опухолью печени с описанием тактики применения антитромботической терапии на фоне тромбоцитопении. Представлены литературные данные об эпидемиологии венозных тромбозов (ВТ) среди пациентов детского возраста с онкологическими заболеваниями, патогенезе ВТ, диагностических методах и принципах выбора антитромботической терапии у детей с тромбоэмболическими осложнениями. Подчеркивается роль междисциплинарного взаимодействия в определении тактики ведения пациентов с онкологическими заболеваниями и сопутствующей тромбогеморрагической патологией.

This paper presents a clinical case of portal vein thrombosis in a child with a malignant rhabdoid tumor of the liver with the description of tactics of antithrombotic therapy application in thrombocytopenia. Literature data on the epidemiology of venous thrombosis among pediatric patients with cancer, the pathogenesis of venous thrombosis, diagnostic methods and principles of antithrombotic therapy choice in children with thromboembolic sequela are presented. The role of interdisciplinary interaction in determining the treatment tactics of patients with cancer and concomitant thrombohemorrhagic pathology is emphasized.

венозный тромбоззлокачественное новообразованиезлокачественная рабдоидная опухоль печенитромбоз воротной веныантитромботическая терапиянефракционированный гепариннизкомолекулярный гепариндетиvenous thrombosismalignancymalignant rhabdoid tumor of the liverportal vein thrombosisantithrombotic therapyunfractionated heparinlow-molecular heparinchildrenReferencesSetty B.A., O, Brien S.H., Kerlin B.A. Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases. Pediatr Blood Cancer 2012;59(2):258–64.Setty B.A., O, Brien S.H., Kerlin B.A. Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases. Pediatr Blood Cancer 2012;59(2):258–64.Faustino E.V., Hanson S., Spinella P.C. et al. PROphylaxis against ThRombosis prACTice (PROTRACT) Study Investigators of the PALISI BloodNet. A multinational study of thromboprophylaxis practice in critically ill children. Crit Care Med 2014;42(5):1232–40.Faustino E.V., Hanson S., Spinella P.C. et al. PROphylaxis against ThRombosis prACTice (PROTRACT) Study Investigators of the PALISI BloodNet. A multinational study of thromboprophylaxis practice in critically ill children. Crit Care Med 2014;42(5):1232–40.Wiernikowski J.T., Athale U.H. Thromboembolic complications in children with cancer. Thromb Res 2006;118(1):137–52.Wiernikowski J.T., Athale U.H. Thromboembolic complications in children with cancer. Thromb Res 2006;118(1):137–52.Athale U.H., Chan A.K. Thromboembolic complications in pediatric hematologic malignancies. Semin Thromb Hemost 2007;33(4):416–26.Athale U.H., Chan A.K. Thromboembolic complications in pediatric hematologic malignancies. Semin Thromb Hemost 2007;33(4):416–26.Knöfler R., Siegert E., Lauterbach I. et al. Clinical importance of prothrombotic risk factors in pediatric patients with malignancy – impact of central venous lines. Eur J Pediatr 1999;158 Suppl 3:S147–50.Knöfler R., Siegert E., Lauterbach I. et al. Clinical importance of prothrombotic risk factors in pediatric patients with malignancy – impact of central venous lines. Eur J Pediatr 1999;158 Suppl 3:S147–50.Glaser D.W., Medeiros D., Rollins N. et al. Catheter-related thrombosis in children with cancer. J Pediatr 2001;138(2):255–9.Glaser D.W., Medeiros D., Rollins N. et al. Catheter-related thrombosis in children with cancer. J Pediatr 2001;138(2):255–9.Athale U. Thrombosis in pediatric cancer: identifying the risk factors to improve care. Expert Rev Hematol 2013;6(5):599–609.Athale U. Thrombosis in pediatric cancer: identifying the risk factors to improve care. Expert Rev Hematol 2013;6(5):599–609.Raffini L., Huang Y.S., Witmer C. et al. Dramatic increase in venous thromboembolism in children»s hospitals in the United States from 2001 to 2007. Pediatrics 2009;124(4):1001–8.Raffini L., Huang Y.S., Witmer C. et al. Dramatic increase in venous thromboembolism in children»s hospitals in the United States from 2001 to 2007. Pediatrics 2009;124(4):1001–8.Paz-Priel I., Long L., Helman L.J. et al. Thromboembolic events in children and young adults with pediatric sarcoma. J Clin Oncol 2007;25(12):1519–24.Paz-Priel I., Long L., Helman L.J. et al. Thromboembolic events in children and young adults with pediatric sarcoma. J Clin Oncol 2007;25(12):1519–24.Bosch F.X., Ribes J., Díaz M. et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127(5 Suppl 1):5–16.Bosch F.X., Ribes J., Díaz M. et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127(5 Suppl 1):5–16.Lin J., Zhou K.-R., Chen Z.-W. et al. Three-dimensional contrast-enhanced MR angiography in diagnosis of portal vein involvement by hepatic tumors. World J Gastroenterol 2003;9(5): 1114–8.Lin J., Zhou K.-R., Chen Z.-W. et al. Three-dimensional contrast-enhanced MR angiography in diagnosis of portal vein involvement by hepatic tumors. World J Gastroenterol 2003;9(5): 1114–8.Zhou L., Rui J.A., Wang S.B. et al. Risk factors of microvascular invasion, portal vein tumor thrombosis and poor post-resectional survival in HBV-related hepatocellular carcinoma. Hepatogastroenterology 2014;61(134): 1696–703.Zhou L., Rui J.A., Wang S.B. et al. Risk factors of microvascular invasion, portal vein tumor thrombosis and poor post-resectional survival in HBV-related hepatocellular carcinoma. Hepatogastroenterology 2014;61(134): 1696–703.Giorgio A., Calisti G., Montesarchio L. et al. Hepatocellular carcinoma invading portal venous system in cirrhosis: long-term results of percutaneous radiofrequency ablation of both the nodule and portal vein tumor thrombus. A case control study. Anticancer Res 2014;34(11):6785–90.Giorgio A., Calisti G., Montesarchio L. et al. Hepatocellular carcinoma invading portal venous system in cirrhosis: long-term results of percutaneous radiofrequency ablation of both the nodule and portal vein tumor thrombus. A case control study. Anticancer Res 2014;34(11):6785–90.Wang J.N., Chen J.S., Chuang H.Y. et al. Invasion of the cardiovascular system in childhood malignant hepatic tumors. J Pediatr Hematol Oncol 2002;24(6): 436–9.Wang J.N., Chen J.S., Chuang H.Y. et al. Invasion of the cardiovascular system in childhood malignant hepatic tumors. J Pediatr Hematol Oncol 2002;24(6): 436–9.Isaacs H. Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg 2007;42(11):1797–803.Isaacs H. Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg 2007;42(11):1797–803.Litten J.B., Tomlinson G.E. Liver tumors in children. Oncologist 2008;13(7):812–20.Litten J.B., Tomlinson G.E. Liver tumors in children. Oncologist 2008;13(7):812–20.Chalmers E., Ganesen V., Liesner R. et al. British Committee for Standards in Haematology. Guideline on the investigation, management and prevention of venous thrombosis in children. Br J Haematol 2011;154(2):196–207.Chalmers E., Ganesen V., Liesner R. et al. British Committee for Standards in Haematology. Guideline on the investigation, management and prevention of venous thrombosis in children. Br J Haematol 2011;154(2):196–207.Cohen A.T., Spiro T.E., Spyropoulos A.C. et al. D-dimer as a predictor of venous thromboembolism in acutely ill, hospitalized patients: a subanalysis of the randomized controlled MAGELLAN trial. J Thromb Haemost 2014;12(4):479–87.Cohen A.T., Spiro T.E., Spyropoulos A.C. et al. D-dimer as a predictor of venous thromboembolism in acutely ill, hospitalized patients: a subanalysis of the randomized controlled MAGELLAN trial. J Thromb Haemost 2014;12(4):479–87.Kenet G., Nowak-Göttl U. Venous thromboembolism in neonates and children. Best Pract Res Clin Haematol 2012;25(3):333–44.Kenet G., Nowak-Göttl U. Venous thromboembolism in neonates and children. Best Pract Res Clin Haematol 2012;25(3):333–44.Lee A.Y., Peterson E.A. Treatment of cancer-associated thrombosis. Blood 2013;122(14):2310–7.Lee A.Y., Peterson E.A. Treatment of cancer-associated thrombosis. Blood 2013;122(14):2310–7.Monagle P., Chan A.K., Goldenberg N.A. et al. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):737–801.Monagle P., Chan A.K., Goldenberg N.A. et al. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):737–801.

The authors declare that there are no conflicts of interest present.