Преимущества и недостатки методов ядерной медицины, используемых при диагностике у пациентов с нейробластомой (обзор литературы)
Аннотация
На момент постановки диагноза приблизительно у 50 % пациентов с нейробластомой (НБ) определяется распространенная форма заболевания. Поэтому правильное стадирование с использованием методов лучевой диагностики и ядерной медицины имеет важнейшее значение у таких больных. Метайодбензилгуанидин (МЙБГ) является аналогом норадреналина и это идеальный туморотропный препарат для визуализации опухолевых клеток, экспрессирующих переносчики норадреналина. К основным недостаткам сцинтиграфии с МЙБГ следует отнести ограниченное пространственное разрешение, низкую чувствительность при диагностике опухолей малых размеров, существование НБ, клетки которых не накапливают МЙБГ, длительность исследования и необходимость выполнения нескольких протоколов сканирования. Позитронно-эмиссионная томография с соответствующим радиофармпрепаратом может стать хорошей альтернативой сцинтиграфии с МЙБГ и помочь при сомнительных и противоречивых результатах.
Ключевые слова
Об авторах
А. Кайлаш
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России
Россия
Россия
117997, Москва, ул. Саморы Машела, 1
Ю. Н. Ликарь
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России
Россия
Россия
117997, Москва, ул. Саморы Машела, 1
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Для цитирования:
Кайлаш А., Ликарь Ю.Н. Преимущества и недостатки методов ядерной медицины, используемых при диагностике у пациентов с нейробластомой (обзор литературы). Российский журнал детской гематологии и онкологии (РЖДГиО). 2016;3(2):50-56. https://doi.org/10.17650/2311-1267-2016-3-2-50-56
For citation:
Kailash A., Likar Yu.N. Advantages and disadvantages of nuclear medicine techniques used in the diagnosis of patients with neuroblastoma (a review). Russian Journal of Pediatric Hematology and Oncology. 2016;3(2):50-56. (In Russ.) https://doi.org/10.17650/2311-1267-2016-3-2-50-56
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