The first experience of using immunotherapy in a patient with a recurrence of neuroblastoma

Abstract

Neuroblastoma (NB) is one of the most common childhood solid tumors. Current problem of children’s oncology is treatment of patients from high-risk NB. Now the standard of treatment of these patients is application of the stage-by-stage therapy including induction, consolidation, and post-consolidation. During induction the maximum reduction of the primary tumor and the metastasis for a possibility of optimum local control is reached. Consolidation consists in high-dose chemotherapy which purpose is to consolidate the reached remission. After the completions of treatment patients receive the maintenance therapy, the standard is use of the differentiating therapy in combination with monoclonal anti-GD2-antibody (dinutuximab). Certainly, this tactics allowed achieving considerable progress in treatment of primary patients with unfavorable prognosis. Options of treatment for high-risk NB depend on some factors. Certainly, the tumor dissemination is characterized by extremely adverse forecast for life and recovery of the patient. However a local recurrence can be successfully cured. The purpose of this study is to demonstrate a rare clinical case of therapy from isolated central nervous system NB recurrence.

Conflict of interest. The authors declare no conflict of interest.

Funding. The study was performed without external funding.