F359C mutation of the BCR-ABL1 gene in adolescent with chronic myeloid leukemia. Case report
https://doi.org/10.21682/2311-1267-2019-6-2-72-75
Abstract
Chronic myeloid leukemia (CML) in children is rare, less than 3 % of all cases of leukemia in pediatric practice. Along with the successes achieved in the treatment of CML with imatinib, it’s necessary to study of molecular factors in predicting resistance to therapy. According to the literature, about 30 % of adult patients with imatinib resistance have point mutations in the kinase domain of BCR-ABL1 gene. The number of reports about mutation spectrum of the BCR-ABL1 gene in children with resistant forms of CML is limited. This article describes the clinical case of secondary resistance to imatinib in a 15-year-old girl with the F359C mutation of BCR-ABL1 gene and a review of the literature.
About the Authors
M. V. Borisevich
Republican Scientific and Practical Center for Pediatric Oncology, Hematology and Immunology, Ministry of Health of the Republic of Belarus
Belarus
Belarus
Deputy Director for organizational and methodical work
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
T. V. Savitskaya
Republican Scientific and Practical Center for Pediatric Oncology, Hematology and Immunology, Ministry of Health of the Republic of Belarus
Belarus
Belarus
Cand. of Sci. (Biol.), Leading Researcher Research Department
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
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Review
For citations:
Borisevich M.V., Savitskaya T.V. F359C mutation of the BCR-ABL1 gene in adolescent with chronic myeloid leukemia. Case report. Russian Journal of Pediatric Hematology and Oncology. 2019;6(2):72-75. (In Russ.) https://doi.org/10.21682/2311-1267-2019-6-2-72-75
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