Таргетная терапия в лечении метастатических, рецидивных и рефрактерных форм саркомы Юинга и остеогенной саркомы. Обзор литературы
Аннотация
Остеогенная саркома (ОС) и саркома Юинга (СЮ) – наиболее часто встречающиеся костные саркомы у детей, подростков и молодых взрослых. Пациенты с метастатическим распространением, рецидивом или рефрактерной формой заболевания имеют неблагоприятный прогноз: 5-летняя общая выживаемость не превышает 20–30 %. В настоящее время проводятся исследования в целях поиска новых мишеней и путей воздействия на эти опухоли. Цель данного обзора – представить актуальные данные из мировой литературы о потенциально эффективных таргетных препаратах для пациентов с метастатическим распространением, рецидивом или рефрактерными формами ОС и СЮ.
Ключевые слова
Об авторах
Д. А. Моргачева
ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России
Россия
Россия
врач-детский онколог отделения химиотерапии онкогематологических заболеваний и трансплантации костного мозга,
197341, Санкт-Петербург, ул. Аккуратова, 2
Д. Ю. Панова
ООО «Современная медицина»
Россия
Россия
врач-терапевт участковый,
197341, Санкт-Петербург, Коломяжский просп., 20
М. Б. Белогурова
ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России;
ГБУЗ «Санкт-Петербургский клинический научно-практический центр специализированных
видов медицинской помощи (онкологический)»
Россия
Россия
д.м.н., профессор, ведущий научный сотрудник, 197341, Санкт-Петербург, ул. Аккуратова, 2;
заведующая детским онкологическим отделением, 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68А
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Для цитирования:
Моргачева Д.А., Панова Д.Ю., Белогурова М.Б. Таргетная терапия в лечении метастатических, рецидивных и рефрактерных форм саркомы Юинга и остеогенной саркомы. Обзор литературы. Российский журнал детской гематологии и онкологии (РЖДГиО). 2021;8(1):57-63. https://doi.org/10.21682/2311-1267-2021-8-1-57-63
For citation:
Morgacheva D.A., Panova D.Yu., Belogurova M.B. Targeted therapy in metastatic, recurrent and refractory Ewing sarcoma and osteogenic sarcoma. Review of literature. Russian Journal of Pediatric Hematology and Oncology. 2021;8(1):57-63. (In Russ.) https://doi.org/10.21682/2311-1267-2021-8-1-57-63
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