A review of pharmacogenetic aspects of methotrexate and 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia treatment
https://doi.org/10.21682/2311-1267-2021-8-3-79-85
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Abstract
Significant progress in the treatment of acute lymphoblastic leukemia (ALL) in children has resulted from the development of effective chemoand supportive care therapy protocols. The vector of further research is aimed at reducing toxicity and long-term side effects. The study of pharmacogenetic aspects of toxicity of the main drugs used in the treatment of ALL – methotrexate and 6-mercaptopurine – allowed to identify oligonucleotide polymorphisms that correlate with the concentration of the drug in blood, toxic effects and the risk of relapse of ALL. The clinical administration of pharmacogenetic methods remains a challenging task, requiring additional research, which will make it possible to individualize the ALL therapy on the basis of the results of molecular profiling.
About the Authors
О. D. Gurieva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 1 of the Research Institute of Pediatric Oncology and Hematology
23 Kashirskoe Shosse, Moscow, 115478
Bld. 1, 2/1 Barrikadnaya St., Moscow, 125993
М. I. Savelyeva
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor at the Department of Clinical Pharmacology and Therapy named after Academician B.E. Votchal
Bld. 1, 2/1 Barrikadnaya St., Moscow, 125993
Т. Т. Valiev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 1 of the Research Institute of Pediatric Oncology and Hematology; Professor at the Department of Pediatric Oncology named after Academician L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115478
Bld. 1, 2/1 Barrikadnaya St., Moscow, 125993
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For citations:
Gurieva О.D., Savelyeva М.I., Valiev Т.Т. A review of pharmacogenetic aspects of methotrexate and 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia treatment. Russian Journal of Pediatric Hematology and Oncology. 2021;8(3):79-85. (In Russ.) https://doi.org/10.21682/2311-1267-2021-8-3-79-85
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ISSN 2413-5496 (Online)
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