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The use of Jelonet dressings in the treatment of drug toxicity in autologous stem cell transplantation in children. Clinical case presentation

https://doi.org/10.21682/2311-1267-2021-8-3-97-101

Abstract

One of the complications arising at the stage of hematopoietic stem cell transplantation (HSCT) is skin lesions. This complication is quite common and represents an important diagnostic and therapeutic problem. The main cause of skin lesions in HSCT is drug toxicity, but also infectious lesions. Each of the complications can manifest itself in varying degrees, as well as be combined with others, having a significant negative effect on the patient’s condition, in severe cases posing a threat to the patient’s life. This paper presents a clinical case of a patient with treosulfan toxicoderma who was treated with JELONET dressings.

About the Authors

T. Z. Aliev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Pediatric Oncologist Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit of the Research Institute of Pediatric Oncology and Hematology

23 Kashirskoe Shosse, Moscow, 115478



T. S. Belysheva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Dermatologist, Leading Researcher Scientific Advisory Division Research Institute of Pediatric Oncology and Hematology 

23 Kashirskoe Shosse, Moscow, 115478



K. A. Sergeenko
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation

Resident of the Department of Pediatric Oncology named after Academician L.A. Durnov 

Bld. 1, 2/1 Barrikadnaya St., Moscow, 125993



E. B. Machneva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Hematologist Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit of the Research Institute of Pediatric Oncology and Hematology; Hematologist Department of Bone Marrow Transplantation 

23 Kashirskoe Shosse, Moscow, 115478

117 Leninskiy Prosp., Moscow, 117997



N. V. Sidorova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Head of the Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit of the Research Institute of Pediatric Oncology and Hematology

23 Kashirskoe Shosse, Moscow, 115478



T. T. Valiev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of the Children’s Department of Hemoblastosis Chemotherapy of the Department of Hematology and Bone Marrow Transplantation

23 Kashirskoe Shosse, Moscow, 115478



I. O. Kostareva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Pediatric Oncologist Department of Pediatric Oncology and Hematology with a Bone Marrow Transplant Unit of the Research Institute of Pediatric Oncology and Hematology; Researcher Department of Treatment Optimization and Prophylaxis of Hematopoietic Stem Cell Transplantation Associated Complications 

23 Kashirskoe Shosse, Moscow, 115478

1 Samory Mashela St., Moscow, 117997



K. I. Kirgizov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Deputy Director for Scientific and Educational Work of the Research Institute of Pediatric Oncology and Hematology

23 Kashirskoe Shosse, Moscow, 115478



References

1. Rosman I.S., Lloyd B.M., Hayashi R.J., Bayliss S.J. Cutaneous effects of thiotepa in pediatric patients receiving high-dose chemotherapy with autologous stem cell transplantation. J Am Acad Dermatol 2008;58(4):575–8. doi: 10.1016/j.jaad.2007.12.037.

2. The EBMT Handbook. Hematopoietic Stem Cell Transplantation and Cellular Therapies. Eds.: Carreras E., Dufour C., Mohty M., Kröger N. Springer, 2019. 688 р. doi: 10.1007/978-3-030-02278-5

3. Mays S.R., Kunishige J.H., Truong E., Kontoyiannis D.P., Hymes S.R. Approach to the morbilliform eruption in the hematopoietic transplant patient. Semin Cutan Med Surg 2007;26(3):155–62. doi: 10.1016/j.sder.2007.09.004.

4. Strocchio L., Zecca M., Comoli P., Mina T., Giorgiani G., Giraldi E., Vinti L., Merli P., Regazzi M., Locatelli F. Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in children with sickle cell disease. Br J Haematol 2015;169(5):726–36. doi: 10.1111/bjh.13352.

5. Bolognia J.L., Cooper D.L., Glusac E.J. Toxic erythema of chemotherapy: a useful clinical term. J Am Acad Dermatol 2008;59(3):524–9. doi: 10.1016/j.jaad.2008.05.018.

6. Алиев Т.З., Мачнева Е.Б. Сидорова Н.В., Белышева Т.С., Валиев Т.Т., Киргизов К.И. Поражение кожных покровов при трансплантации гемопоэтических стволовых клеток. Обзор литературы. Вопросы гематологии/онкологии и иммунопатологии в педиатрии 2020;19(2):184–92. doi: 10.24287/1726-1708-2020-19-2-184-192. [Aliev T.Z., Machneva E.B., Sidorova N.V., Belysheva T.S., Valiev T.T., Kirgizov K.I. Skin damage after the hematopoietic stem cell transplantation. Literature review. Voprosy gematologii/onkologii i immunopatologii v pediatrii = Pediatric Hematology/Oncology and Immunopathology 2020;19(2):184–92. (In Russ.)].

7. Руководство по эксплуатации от производителя Smith & Nephew Medical Limited, 101 Hessle Road, Hull HU3 2BN, England, 2015.

8. Foyatier J.L., Hezez G., Masson C.L., Latarjet J. Use of a neutral paraffin dressing (Jelonet) at the Burn Care Center at the Saint Luc Hospital in Lyon. Ann Chir Plast Esthet 1990;35(4):327–30. PMID: 1702958.

9. Rothenberger J., Constantinescu M.A., Held M., Aebersold D.M., Stolz A., Tschumi C., Olariu R. Use of a Polylactide-based Copolymer as a Temporary Skin Substitute for a Patient With Moist Desquamation Due to Radiation. Wounds 2016;28(7):E26–30. PMID: 27428721.

10. Schwarze H., Küntscher M., Uhlig C., Hierlemann H., Prantl L., Noack N., Hartmann B. Suprathel, a new skin substitute, in the management of donor sites of split-thickness skin grafts: results of a clinical study Burns 2007;33(7):850–4. doi: 10.1016/j.burns.2006.10.393.


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For citations:


Aliev T.Z., Belysheva T.S., Sergeenko K.A., Machneva E.B., Sidorova N.V., Valiev T.T., Kostareva I.O., Kirgizov K.I. The use of Jelonet dressings in the treatment of drug toxicity in autologous stem cell transplantation in children. Clinical case presentation. Russian Journal of Pediatric Hematology and Oncology. 2021;8(3):97-101. (In Russ.) https://doi.org/10.21682/2311-1267-2021-8-3-97-101

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ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
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