Preview

Russian Journal of Pediatric Hematology and Oncology

Advanced search

Endoscopic nephrectomy and kidney resection in children with renal cell carcinoma. Description of clinical cases and literature review

https://doi.org/10.21682/2311-1267-2021-8-3-109-115

Abstract

In spite of the fact that nephoblastoma is a most common pediatric renal tumor, there are periods, during which other renal malignancies are prevalent. Renal cell carcinoma (RCC) becomes increasingly more prevalent with age and has to be reckoned with while choosing diagnostic algorithms and treatment tactics in adolescents.
We present two cases of adolescents with localized RCC. In both cases laparoscopic interventions, nephrectomy and tumor resection, were used without pre-operative chemotherapy. The treatment decision on initial surgical treatment was based on visualization results, in one case additional data was provided by fine needle biopsy.
These cases highlight the importance of differential diagnosis and visualization data-based treatment interventions in adolescents with renal tumors. The fine needle biopsy may provide some additional data which potentially may allow implying less traumatic laparoscopic surgery and potentially allow nephron-sparing interventions.

About the Authors

A. N. Zayceva
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Pediatric Urologist Surgical Department of the Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation

12 Rentgena St., Saint Petersburg, 197022



S. A. Reva
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Urologist, Head of 6th Oncology Department of Surgery and Emergency Medicine Institute

12 Rentgena St., Saint Petersburg, 197022



N. N. Gurgenidze
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Pediatric Surgeon Surgical Department of Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Teaching Fellow for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev

12 Rentgena St., Saint Petersburg, 197022



A. N. Shvetsov
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

MD, Head of Surgery Department of the Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation

12 Rentgena St., Saint Petersburg, 197022



I. V. Kazantsev
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Pediatric Oncologist 2nd Pediatric Transplant Department of Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Teaching Fellow for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev

12 Rentgena St., Saint Petersburg, 197022



A. G. Gevorgyan
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Head of the 2nd Pediatric Transplant Department of Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Assistant Professor for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev 

12 Rentgena St., Saint Petersburg, 197022



A. A. Zakharenko
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of the Department of Oncosurgery of Surgery and Emergency Medicine Institute  

12 Rentgena St., Saint Petersburg, 197022



A. D. Kulagin
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Director of Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Head for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev

12 Rentgena St., Saint Petersburg, 197022



L. S. Zubarovskaya
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Deputy Director for Transplantation, Head of the Department of Pediatric Oncology, Hematology and Transplantology at Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Professor for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev 

12 Rentgena St., Saint Petersburg, 197022



Yu. A. Punanov
First Pavlov State Medical University of St. Petersburg, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Professor for Hematology, Transfusiology and Transplantation Chair named after Professor B.V. Afanasyev

12 Rentgena St., Saint Petersburg, 197022



References

1. Nakata K., Colombet M., Stiller C.A., Pritchard-Jones K., SteliarovaFoucher E., IICC-3 Contributors. Incidence of childhood renal tumors: An international population-based study. Int J Cancer 2020;147(12):3313–27. doi: 10.1002/ijc.33147.

2. Wang J., Li M., Tang D., Gu W., Mao J., Shu Q. Current treatment for Wilms tumor: COG and SIOP standards. World J Pediatr Surg 2019;2:e000038. doi: 10.1136/wjps-2019-000038.

3. van den Heuvel-Eibrink M.M., Hol J.A., Pritchard-Jones K., van Tinteren H., Furtwängler R., Verschuur A.C., Vujanic G.M., Leuschner I., Brok J., Rübe C., Smets A.M., Janssens G.O., Godzinski J., Ramírez-Villar L., de Camargo B., Segers H., Collini P., Gessler M., Bergeron C., Spreafico F., Graf N.; International Society of Pediatric Oncology – Renal Tumour Study Group (SIOP-RTSG). Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol 2017;14(12):743–52. doi: 10.1038/nrurol.2017.163.

4. van der Beek J.N., Geller J.I., de Krijger R.R., Graf N., Pritchard-Jones K., Drost J., Vershuur A.C., Murphy D., Ray S., Spreafico F., Dzhuma K., Littoooij A.S., Selle B., Tytgat G.A.M., van den Heuvel-Eibrink M.M. Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review. Cancers (Basel) 2020;12(7):1776. doi: 10.3390/cancers12071776.

5. Spreafico F., Collini P., Terenziani M., Marchianò A., Piva L. Renal cell carcinoma in children and adolescents. Expert Rev Anticancer Ther 2010;10(12):1968–78. doi: 10.1586/era.10.188.

6. Geller J.I., Ehrlich P.F., Cost N.G., Khanna G., Mullen E.A., Gratias E.J., Naranjo A., Dome J.S., Perlman E.J. Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children’s Oncology Group study AREN03B2. Cancer 2015;121(14):2457–64. doi: 10.1002/cncr.29368.

7. Rialon K.L., Gulack B.C., Englum B.R., Routh J.C., Rice H.E. Factors impacting survival in children with renal cell carcinoma. J Pediatr Surg 2015;50(6):1014–8. doi: 10.1016/j.jpedsurg.2015.03.027.

8. Liu G., Ma Y., Wang S., Han X., Gao D. Laparoscopic Versus Open Radical Nephrectomy for Renal Cell Carcinoma: a Systematic Review and Meta-Analysis. Transl Oncol 2017;10(4):501–10. doi: 10.1016/j.tranon.2017.03.004.

9. Padala S.A., Barsouk A., Thandra K.C., Saginala K., Mohammed A., Vakiti A., Rawla P., Barsouk A. Epidemiology of Renal Cell Carcinoma. World J Oncol 2020;11(3):79–87. doi: 10.14740/wjon1279.

10. Cajaiba M.M., Dyer L.M., Geller J.I., Jennings L.J., George D., Kirschmann D., Rohan S.M., Cost N.S., Khanna G., Mullen E.A., Dome J.S., Fernandez C.V., Perlman E.J. The classification of pediatric and young adult renal cell carcinomas registered on the Children’s Oncology Group (COG) protocol AREN03B2 after focused genetic testing. Cancer 2018;124(16):3381–9. doi: 10.1002/cncr.31578.

11. Indolfi P., Terenziani M., Casale F., Carli M., Bisogno G., Schiavetti A., Manchini A., Rondelli R., Pession A., Jenkner A., Pierani P., Tamaro P., De Bernardi B., Ferrari A., Santoro N., Giuliano M., Ceccetto G., Piva L., Surico G., Di Tullio M.T. Renal cell carcinoma in children: a clinicopathological study. J Clin Oncol 2003;21(3):530–5. doi: 10.1200/JCO.2003.02.072.

12. Graf N., Furtwängler R. Preoperative chemotherapy and local stage III in nephroblastoma. Transl Pediatr 2014;3(1):4–11. doi: 10.3978/j.issn.2224-4336.2013.12.02.

13. Chung E.M., Lattin G.E. Jr, Fagen K.E., Kim A.M., Pavio M.A., Fehringer A.J., Conran R.M. Renal Tumors of Childhood: RadiologicPathologic Corelation Part 2. The 2nd Decade: From the Radiologic Pathology Archives. Radiographics 2017;37(5):1538–58. doi: 10.1148/rg.2017160189.

14. Jackson T.J., Williams R.D., Brok J., Chowdhury T., Ronghe M., Powis M., Pritchard-Jones K., Vujanić G.M., Children’s Cancer and Leukaemia Group (CCLG) Renal Tumours Group. The diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: Report of the UK experience in the SIOP UK WT 2001 trial. Pediatr Blood Cancer 2019;66(6):e27627. doi: 10.1002/pbc.27627.

15. Burnand K., Roberts A., Bouty A., Nightingale M., Campbell M., Heloury Y. Laparoscopic nephrectomy for Wilms’ tumor: Can we expand on the current SIOP criteria? J Pediatr Urol 2018;14(3):253.e1–e8. doi: 10.1016/j.jpurol.2018.01.005.

16. Dome J.S., Geller J.I. Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer 2004;101(7):1575–83. doi: 10.1002/cncr.20548.

17. Saltzman A.F., Stokes W., Walker J., Cost N.G. Factors related to lymph node sampling at the time of surgery in children, adolescents, and young adults with unilateral non-metastatic renal cell carcinoma. J Pediatr Urol 2019;15(3):259.e1–e7. doi: 10.1016/j.jpurol.2019.01.009.

18. Xu C., Lin C., Xu Z., Feng S., Zheng Y. Tumor Enucleation vs. Partial Nephrectomy for T1 Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. Front Oncol 2019;9:473. doi: 10.3389/fonc.2019.00473.

19. Wang X.J., Qu B.Q., Zhou J.P., Zhou Q.M., Lu Y.F., Pan Y., Xu J.X., Miu Y.Y., Wang H.Q., Yu R.S. A Non-Invasive Scoring System to Differential Diagnosis of Clear Cell Renal Cell Carcinoma (ccRCC) From Renal Angiomyolipoma Without Visible Fat (RAML-wvf) Based on CT Features. Front Oncol 2021;11:633034. doi: 10.3389/fonc.2021.633034.


Review

For citations:


Zayceva A.N., Reva S.A., Gurgenidze N.N., Shvetsov A.N., Kazantsev I.V., Gevorgyan A.G., Zakharenko A.A., Kulagin A.D., Zubarovskaya L.S., Punanov Yu.A. Endoscopic nephrectomy and kidney resection in children with renal cell carcinoma. Description of clinical cases and literature review. Russian Journal of Pediatric Hematology and Oncology. 2021;8(3):109-115. (In Russ.) https://doi.org/10.21682/2311-1267-2021-8-3-109-115

Views: 459


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
X