Problems of clinical and morphologic diagnosis of orolabial melanosis in children
https://doi.org/10.21682/2311-1267-2021-8-3-116-122
Abstract
Pigmented neoplasms of the skin and mucous membranes are a heterogeneous group of benign and malignant neoplasms, some of which are extremely rare in the practice of pediatric oncologist. Orolabial melanosis refers to a benign pigmented pathology of the skin and mucous membranes, requires differential diagnosis with ephelids, melanoma, and when localized on the tongue – with pigmented fungiform papillae of the tongue.
This article presents a clinical case of orolabial melanosis with localization on the tongue in a 9-year-old child that was not previously described in the domestic literature. The clinical, dermatoscopic, immuno-morphological and differential diagnostic features of this pathology are described in detail.
About the Authors
T. S. BelyshevaRussian Federation
Dr. of Sci. (Med.), Leading Researcher Scientific Advisory Division
23 Kashirskoe Shosse, Moscow, 115478
Ya. V. Vishnevskaya
Russian Federation
Cand. of Sci. (Med.), Pathologist Pathology Department
23 Kashirskoe Shosse, Moscow, 115478
I. S. Kletskaya
Russian Federation
Pathologist Pathological Department
117 Leninskiy Prosp., Moscow, 117997
A. V. Michenko
Russian Federation
Cand. Of Sci. (Med.), Associate Professor of the Department of Dermatovenereology and Cosmetology
Bld. 1А, 19 Marshal Timoshenko St., Moscow, 121359
A. S. Volkova
Russian Federation
Resident
23 Kashirskoe Shosse, Moscow, 115478
T. T. Valiev
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) No. 1; Associate Professor Department of Oncology
23 Kashirskoe Shosse, Moscow, 115478
Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow, 119991
S. N. Mikhailova
Russian Federation
Cand. of Sci. (Med.), Head of Scientific Advisory Division
23 Kashirskoe Shosse, Moscow, 115478
S. R. Varfolomeeva
Russian Federation
Dr. of Sci. (Med.), Professor, Director
23 Kashirskoe Shosse, Moscow, 115478
References
1. Müller S. Melanin-associated pigmented lesions of the oral mucosa: presentation, differential diagnosis, and treatment. Dermatol Ther 2010;23(3):220–9. doi: 10.1111/j.1529-8019.2010.01319.x.
2. Kaugars G.E., Heise A.P., Riley W.T., Abbey L.M., Svirsky J.A. Oral melanotic macules. A review of 353 cases. Oral Surg Oral Med Oral Pathol 1993;76(1):59–61. doi: 10.1016/0030-4220(93)90295-f.
3. Gupta G., Williams R.E., Mackie R.M. The labial melanotic macule: a review of 79 cases. Br J Dermatol 1997;136(5):772–5. PMID: 9205516.
4. Shen Z.-Y., Liu W., Bao Z.-X., Zhou Z.-T., Wang L.-Z. Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(1):e21–5. doi: 10.1016/j.tripleo.2011.02.040.
5. Ho K.K., Dervan P., O’Loughlin S., Powell F.C. Labial melanotic macule: a clinical, histopathologic, and ultrastructural study. J Am Acad Dermatol 1993;28(1):33–9. doi: 10.1016/0190-9622(93)70005-e.
6. Lee J.S., Mun J.H. Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule. PLoS One 2018;13(10):e0206768. doi: 10.1371/journal.pone.0206768.
7. Chessa M.A., Patrizi A., Sechi A., Virdi A., Leuzzi M., Neri I. Pigmented fungiform lingual papillae: dermoscopic and clinical features. J Eur Acad Dermatol Venereol 2018;32(6):935–9. doi: 10.1111/jdv.14809.
8. Holzwanger J.M., Rodolph R.I., Heaton C.L. Pigmented fungiform papillae of the tongue: a common variant of oral pigmentation. Int J Dermatol 1974;13(6):403–8. doi: 10.1111/j.1365-4362.1974.tb05073.x.
9. Dohil M.A., Billman G., Pransky S., Eichenfield L.F. The Congenital Lingual Melanotic Macule. Arch Dermatol 2003;139(6):767–70. doi: 10.1001/archderm.139.6.767.
10. Page L.R., Corio R.L., Crawford B.E., Giansanti J.S., Weathers D.R. The oral melanotic macule. Oral Surg Oral Med Oral Pathol 1977;44(2):219–26. doi: 10.1016/0030-4220(77)90272-9.
11. Meleti M., Vescovi P., Mooi W.J., van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105(5):606–16. doi: 10.1016/j.tripleo.2007.07.047.
12. Eisen D. Disorders of pigmentation in the oral cavity. Clin Dermatol 2000;18(5):579–87. doi: 10.1016/s0738-081x(00)00148-6.
13. Savoia F., Ricci L., Patrizi A., Gaddoni G. Congenital Melanotic Macules of the Tongue. A Case Report and Brief Review of the Literature. Pediatr Dermatol 2014;32(1):109–12. doi: 10.1111/pde.12472.
14. Kumar C., Sharma D., Pandita A., Shastri S. Congenital Lingual Melanotic Macule: Rare entity in infants. Sultan Qaboos Univ Med J 2015;15(3):e440–1. doi: 10.18295/squmj.2015.15.03.024.
15. Mun S.J., Jung H.Y., Frolova A., Park K.D., Rhee C.S. Malignant mucosal melanoma in the olfactory cleft of a 10-year-old child. Auris Nasus Larynx 2013;40(2):235–8. doi: 10.1016/j.anl.2012.05.001.
16. Abduljabbar T., Vohra F., Akram Z., Ghani S.M.A., Al-Hamoudi N., Javed F. Efficacy of surgical laser therapy in the management of oral pigmented lesions: A systematic review. J Photochem Photobiol B 2017;173:353–9. doi: 10.1016/j.jphotobiol.2017.06.016.
17. Волгарева Г.М., Белышева Т.С., Завалишина Л.Э., Хестанов Д.Б., Бурова О.С., Вишневская Я.В., Алиев М.Д. Врожденное пигментное новообразование кожи у ребенка: опыт диагностики. Российский биотерапевтический журнал 2019;18(3):63–70. doi: 10.17650/1726-9784-2019-18-3-63-70. [Volgareva G.M., Belysheva T.S., Zavalishina L.E., Khestanov D.B., Burova O.S., Vishnevskaya Ya.V., Aliev M.D. Inborn pigment skin malformation in a child: practice of diagnostics. Rossiyskiy bioterapevticheskiy zhurnal = Russian Journal of Biotherapy 2019;18(3):63–70. (In Russ.)].
18. Belysheva T.S., Vishnevskaya Y.V., Nasedkina T.V., Abramov I.S., Orlova K.V., Lubchenko L.N., Utyashev I.A., Doroshenko M.B., Demidov L.V., Aliev M.D., Emelyanova M.A. Melanoma arising in a giant congenital melanocytic nevus: two case reports. Diagnostic Pathology 2019;14(1):21–9. doi: 10.1186/s13000-019-0797-1.
Review
For citations:
Belysheva T.S., Vishnevskaya Ya.V., Kletskaya I.S., Michenko A.V., Volkova A.S., Valiev T.T., Mikhailova S.N., Varfolomeeva S.R. Problems of clinical and morphologic diagnosis of orolabial melanosis in children. Russian Journal of Pediatric Hematology and Oncology. 2021;8(3):116-122. (In Russ.) https://doi.org/10.21682/2311-1267-2021-8-3-116-122