Atipical course of clostridial colitis in child with Hodgkin’s lymphoma
https://doi.org/10.21682/2311-1267-2022-9-3-107-112
Abstract
The wide antibiotics use in different areas of medicine has significantly increased the incidence of pseudomembranous colitis caused by Clostridium difficile. Strong necessity of antibacterial therapy in hematological patients is the reason of a higher frequency of this complication after programmed chemotherapy and hematopoietic stem cell transplantation. The atypical course of clostridial colitis makes it difficult to diagnose, leads to delay of treatment and fatal complications. We presented the case of clostridial colitis with atypical clinical manifestations in the 8-year-old child with Hodgkin’s lymphoma. Disease was complicated by colon perforation and fecal peritonitis, which required surgery and long-term rehabilitation. The analysis of publications devoted to clostridial colitis in patients with hematological malignancies was carried out and possible reasons of its atypical course was reviewed. The ways to improve the diagnosis, treatment and prevention of this serious complication are presented.
About the Authors
A. V. Lyanguzov
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Resercher Department of Organization and Support of Scientific Research. SPIN-code: 9887-8608
72 Krasnoarmeyskaya St., Kirov, 610027
S. V. Ignatyev
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Resercher Department of Organization and Support of Scientific Research. SPIN-code: 7656-3876
72 Krasnoarmeyskaya St., Kirov, 610027
S. L. Kalinina
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Head of Anaesthesiology and Reanimatology Department. SPIN-code: 1891-1860
72 Krasnoarmeyskaya St., Kirov, 610027
O. M. Tselousova
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of Children’s Department of Hematology and Chemotherapy. SPIN-code: 5177-8963
72 Krasnoarmeyskaya St., Kirov, 610027
I. P. Tataurova
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Hematologist Children’s Department of Hematology and Chemotherapy
72 Krasnoarmeyskaya St., Kirov, 610027
D. A. Dyakonov
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of Pathomorphological Laboratory. SPIN-code: 6301-6557
72 Krasnoarmeyskaya St., Kirov, 610027
References
1. Shelygin Yu.A., Aleshkin V.A., Sukhina M.A., Mironov A.Yu., Briko N.I., Kozlov R.S., Zverev V.V., Achkasov S.I., Kovalishena O.V., Selkova E.P., Safin A.L., Grenkova T.A., Khalif I.L., Frolov S.A., Kashnikov V.N., Sushkov O.I. Clinical recommendations of the National association of specialists for the healthcare-related infections control and the Russian association of coloproctology on diagnosis, treatment and prophylaxis of Clostridium difficile-associated diarrhea (CDI). Koloproktologiya = Coloproctology. 2018;(3):7–23. (In Russ.) doi: 10.33878/2073-7556-2018-0-3-7-23.
2. Balsells E., Shi T., Leese C., Lyell I., Burrows J., Wiuff C., Campbell H., Kyaw M.H., Nair H. Global burden of Clostridium difficile infections: a systematic review and meta-analysis. J Glob Health. 2019;9(1):010407. doi: 10.7189/jogh.09.010407.
3. Marra A.R., Perencevich E.N., Nelson R.E., Samore M., Khader K., Chiang H.Y., Chorazy M.L., Herwaldt L.A., Diekema D.J., Kuxhausen M.F., Blevins A., Ward M.A., McDanel J.S., Nair R., Balkenende E., Schweizer M.L. Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(1):e1917597. doi: 10.1001/jamanetworkopen.2019.17597.
4. Hall I.C., O’Toole E. Intestinal flora in new-born infants: with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child. 1935;49(2):390–402. doi: 10.1001/archpedi.1935.01970020105010.
5. Larson H.E., Price A.B., Honour P., Borriello S.P. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978;1(8073):1063–6. doi: 10.1016/s0140-6736(78)90912-1.
6. Cammarota G., Gallo A., Ianiro G., Montalto M. Emerging drugs for the treatment of Сlostridium difficile. Expert Opin Emerg Drugs. 2019;24(1):17–28. doi: 10.1080/14728214.2019.1591371.
7. Lessa F.C., Winston L.G., McDonald L.C.; Emerging Infections Program C. difficile Surveillance Team. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372(24):2369–70. doi: 10.1056/NEJMc1505190.
8. Lee H.S., Plechot K., Gohil S., Le J. Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis. Infect Dis Ther. 2021;10(2):687–97. doi: 10.1007/s40121-021-00417-7.
9. Rampling A., Warren R.E., Berry P.J., Swirsky D., Hoggarth C.E., Bevan P.C. Atypical Clostridium difficile colitis in neutropenic patients. Lancet. 1982;2(8290):162–3. doi: 10.1016/s0140-6736(82)91135-7.
10. Binkovitz L.A., Allen E., Bloom D., Long F., Hammond S., Buonomo C., Donnelly L.F. Atypical presentation of Clostridium difficile colitis in patients with cystic fibrosis. AJR Am J Roentgenol. 1999;172(2):517–21. doi: 10.2214/ajr.172.2.9930816.
11. Schmidt-Hieber M., Bierwirth J., Buchheidt D., Cornely O.A., Hentrich M., Maschmeyer G., Schalk E., Vehreschild J.J., Vehreschild M.J.G.T.; AGIHO Working Group. Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol. 2018;97(1):31–49. doi: 10.1007/s00277-017-3183-7.
12. Dokshina I.A., Lyanguzov A.V., Ignatyev S.V., Ignatyev S.V., Sergunina O.Yu., Kalinina S.L., Prokopyev E.S., Dyakonov D.A. Extramedular lesions of a small intestinum in acute myeloid leukemia: case report and literature review. Onkogematologiya = Oncohematology. 2019;14(2):41–7. (In Russ.) doi: 10.17650/1818-8346-2019-14-2-41-47.
13. Moir D.H., Bale P.M. Necropsy findings in childhood leukaemia, emphasizing neutropenic enterocolitis and cerebral calcification. Pathology. 1976;8(3):247–58. doi: 10.3109/00313027609059005.
14. Nesher L., Rolston K.V. Neutropenic enterocolitis, a growing concern in the era of widespread use of aggressive chemotherapy. Clin Infect Dis. 2013;56(5):711–7. doi: 10.1093/cid/cis998.
15. Lavoie Smith E.M., Li L., Chiang C., Thomas K., Hutchinson R.J., Wells E.M., Ho R.H., Skiles J., Chakraborty A., Bridges C.M., Renbarger J. Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia. J Peripher Nerv Syst. 2015;20(1):37–46. doi: 10.1111/jns.12114.
16. Scappaticci G.B., Perissinotti A.J., Nagel J.L., Bixby D.L., Marini B.L. Risk factors and impact of Clostridium difficile recurrence on haematology patients. J Antimicrob Chemother. 2017;72(5):1488–95. doi: 10.1093/jac/dkx005.
17. Ignatev S.V., Lyanguzov A.V., Dokshina I.A., Yanchenko V.A., Lagunova O.R., Pozdeev N.M. Analysing clinical cases of antibiotic-associated colitis in patient with Hodjkin’s lymphoma. Vyatskii medicinskii vestnik = Medical Newsletter of Vyatka. 2018;1(57):67–70. (In Russ.).
18. Klyasova G.A., Malchikova A.O., Tandilova K.S., Blohina E.V., Parovichnikova E.N., Kravchenko S.K., Savchenko V.G. Treatment of candidemia caused by Candida albicans and Candida non-albicans in patients with hematological malignancies. Terapevticheskii arkhiv = Therapeutic Archive. 2019;91(8):84–92. (In Russ.) doi: 10.26442/00403660.2019.08.000385.
19. van Leeuwen P.T., van der Peet J.M., Bikker F.J., Hoogenkamp M.A., Oliveira Paiva A.M., Kostidis S., Mayboroda O.A., Smits W.K., Krom B.P. Interspecies Interactions between Clostridium difficile and Candida albicans. mSphere. 2016;1(6):e00187–16. doi: 10.1128/mSphere.00187-16.
20. Torres-Flores J., Espinoza-Zamora R., Garcia-Mendez J., Cervera-Ceballos E., Sosa-Espinoza A., Zapata-Canto N. Treatment-Related Mortality From Infectious Complications in an Acute Leukemia Clinic. J Hematol. 2020;9(4):123–31. doi: 10.14740/jh751.
21. Revolinski S.L., Munoz-Price L.S. Clostridium difficile in Immunocompromised Hosts: A Review of Epidemiology, Risk Factors, Treatment, and Prevention. Clin Infect Dis. 2019;68(12):2144–53. doi: 10.1093/cid/ciy845.
22. Revolinski S.L., Munoz-Price L.S. Clostridium difficile Exposures, Colonization, and the Microbiome: Implications for Prevention. Infect Control Hosp Epidemiol. 2018;39(5):596–602. doi: 10.1017/ice.2018.36.
23. Kim K.O., Gluck M. Fecal Microbiota Transplantation: An Update on Clinical Practice. Clin Endosc. 2019;52(2):137–43. doi: 10.5946/ce.2019.009.
24. Goloshchapov O.V., Chukhlovin A.B., Bakin E.A., Stanevich O.V., Klementeva R.V., Shcherbakov A.A., Shvetsov A.N., Suvorova M.A., Bondarenko S.N., Kucher M.A., Kulagin A.D., Zubarovskaya L.S., Moiseev I.S. Fecal microbiota transplantation for graft-versus-host disease in children and adults: methods, clinical effects, safety. Terapevticheskii arkhiv = Therapeutic Archive. 2020;92(7):43–54. (In Russ.) doi: 10.26442/00403660.2020.07.000773.
25. Reyna-Figueroa J., Bejarano-Juvera A.A., García-Parra C., Barrón-Calvillo E.E., Queipo-Garcia G.E., Galindo-Delgado P. Decrease of Postchemotherapy Complications with the Use of Probiotics in Children with Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43(4):e457–61. doi: 10.1097/MPH.0000000000001956.
26. Cohen S.A., Woodfield M.C., Boyle N., Stednick Z., Boeckh M., Pergam S.A. Incidence and outcomes of bloodstream infections among hematopoietic cell transplant recipients from species commonly reported to be in over-the-counter probiotic formulations. Transpl Infect Dis. 2016;18(5):699–705. doi: 10.1111/tid.12587.
Review
For citations:
Lyanguzov A.V., Ignatyev S.V., Kalinina S.L., Tselousova O.M., Tataurova I.P., Dyakonov D.A. Atipical course of clostridial colitis in child with Hodgkin’s lymphoma. Russian Journal of Pediatric Hematology and Oncology. 2022;9(3):107-112. (In Russ.) https://doi.org/10.21682/2311-1267-2022-9-3-107-112
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