The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs
https://doi.org/10.21682/2311-1267-2023-10-2-71-76
Abstract
Currently, the daily routine of a molecular pathologist is DNA methylation and RNA and DNA sequencing. The authors, from the standpoint of researchers and clinicians, explain the molecular methods used not only to diagnose brain tumors, but also to search for possible targets for therapy.
About the Authors
M. V. RyzhovaRussian Federation
Dr. of Sci. (Med.), Head of the Pathology Department
16 4th Tverskaya-Yamskaya St., Moscow, 125047
L. V. Olkhova
Russian Federation
Pediatric Oncologist Department of Bone Marrow Transplantation
117 Leninskiy Prosp., Moscow, 117997
L. V. Shishkina
Russian Federation
Cand. of Sci. (Med.), Pathologist Pathology Department
16 4th Tverskaya-Yamskaya St., Moscow, 125047
A. V. Golanov
Russian Federation
Сorresponding Member of the Russian Academy of Medical Sciences, Dr. of Sci. (Med.), Professor, Head of Radiosurgery and Radiotherapy Department with a Day Hospital
16 4th Tverskaya-Yamskaya St., Moscow, 125047
O. G. Zheludkova
Russian Federation
Dr. of Sci. (Med.), Professor, Expert of the Higher Attestation Commission on Pediatric Neuro-Oncology, 38 Aviatorov St., Moscow, 119620
Pediatric Oncologist DTC IIBS named after S. Berezin and Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky Moscow Healthcare Department, Bldg. 3, 2 Yesenin St., S.-Petersburg, 194354
E. V. Kumirova
Russian Federation
Dr. of Sci. (Med.), Pediatric Oncologist, Deputy Chief Physician for Oncology, 1/9 4th Dobryninskiy Per., Moscow, 119049
Chief Lead Officer, 86 Profsoyuznaya St., Moscow, 117977
Scientific Consultant Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov, 23 Kashirskoe Shosse, Moscow, 115522
A. N. Kislyakov
Russian Federation
Head of the Pathology Department
1/9 4th Dobryninskiy Per., Moscow, 119049
D. A. Skobeev
Russian Federation
Pathologist Pathology Department
1/9 4th Dobryninskiy Per., Moscow, 119049
M. B. Belogurova
Russian Federation
Dr. of Sci. (Med.), Professor, Leading Scientific Collaborator of Institution of Hematology, 2 Akkuratova St., S.-Petersburg, 197341
Head of the Department of Chemotherapy and Combined Treatment of Tumors in Children, 68А Leningradskaya St., Pesochny, S.-Petersburg, 197758
Yu. V. Dinikina
Russian Federation
Cand. of Sci. (Med.), Head of the Laboratory of Pediatric Neuro-Immuno-Oncology of the Pesonalized Medicine Centre and Head of the Department of Chemotherapy for Hematologic Diseases and Bone Marrow Transplantation for Children
2 Akkuratova St., S.-Petersburg, 197341
Yu. M. Zabrodskaya
Russian Federation
Dr. of Sci. (Med.), Head of the Research Laboratory for Pathomorphology of the Nervous System
12 Mayakovsky St., S.-Petersburg, 119014
V. A. Grigorenko
Russian Federation
Radiotherapist, Head of the Radiological Department of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
A. E. Druy
Russian Federation
Cand. of Sci. (Med.), Head of the Laboratory of Molecular Oncology
1 Samory Mashela St., Moscow, 117997
L. A. Papusha
Russian Federation
Cand. of Sci. (Med.), Leading Researcher, Head of the Department of Optimization of CNS Tumor Therapy
1 Samory Mashela St., Moscow, 117997
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Review
For citations:
Ryzhova M.V., Olkhova L.V., Shishkina L.V., Golanov A.V., Zheludkova O.G., Kumirova E.V., Kislyakov A.N., Skobeev D.A., Belogurova M.B., Dinikina Yu.V., Zabrodskaya Yu.M., Grigorenko V.A., Druy A.E., Papusha L.A. The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs. Russian Journal of Pediatric Hematology and Oncology. 2023;10(2):71-76. (In Russ.) https://doi.org/10.21682/2311-1267-2023-10-2-71-76