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Russian Journal of Pediatric Hematology and Oncology

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The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs

https://doi.org/10.21682/2311-1267-2023-10-2-71-76

Abstract

Currently, the daily routine of a molecular pathologist is DNA methylation and RNA and DNA sequencing. The authors, from the standpoint of researchers and clinicians, explain the molecular methods used not only to diagnose brain tumors, but also to search for possible targets for therapy.

About the Authors

M. V. Ryzhova
N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of the Pathology Department

16 4th Tverskaya-Yamskaya St., Moscow, 125047



L. V. Olkhova
Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation

Pediatric Oncologist Department of Bone Marrow Transplantation

117 Leninskiy Prosp., Moscow, 117997



L. V. Shishkina
N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Pathologist Pathology Department

16 4th Tverskaya-Yamskaya St., Moscow, 125047



A. V. Golanov
N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of Russia
Russian Federation

Сorresponding Member of the Russian Academy of Medical Sciences, Dr. of Sci. (Med.), Professor, Head of Radiosurgery and Radiotherapy Department with a Day Hospital

16 4th Tverskaya-Yamskaya St., Moscow, 125047



O. G. Zheludkova
Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky Moscow Healthcare Department; Diagnostic and Treatment Center of International Institution for Biological Systems named after Sergey Berezin
Russian Federation

Dr. of Sci. (Med.), Professor, Expert of the Higher Attestation Commission on Pediatric Neuro-Oncology, 38 Aviatorov St., Moscow, 119620

Pediatric Oncologist DTC IIBS named after S. Berezin and Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky Moscow Healthcare Department, Bldg. 3, 2 Yesenin St., S.-Petersburg, 194354



E. V. Kumirova
Morozovskaya Children’s Clinical Hospital of the Moscow City Healthcare Department; Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia; N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Pediatric Oncologist, Deputy Chief Physician for Oncology, 1/9 4th Dobryninskiy Per., Moscow, 119049

Chief Lead Officer, 86 Profsoyuznaya St., Moscow, 117977

Scientific Consultant Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov, 23 Kashirskoe Shosse, Moscow, 115522



A. N. Kislyakov
Morozovskaya Children’s Clinical Hospital of the Moscow City Healthcare Department
Russian Federation

Head of the Pathology Department

1/9 4th Dobryninskiy Per., Moscow, 119049



D. A. Skobeev
Morozovskaya Children’s Clinical Hospital of the Moscow City Healthcare Department
Russian Federation

Pathologist Pathology Department

1/9 4th Dobryninskiy Per., Moscow, 119049



M. B. Belogurova
Almazov National Medical Research Centre, Ministry of Health of Russia; Saint Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological) named after N.P. Napalkov
Russian Federation

Dr. of Sci. (Med.), Professor, Leading Scientific Collaborator of Institution of Hematology, 2 Akkuratova St., S.-Petersburg, 197341

Head of the Department of Chemotherapy and Combined Treatment of Tumors in Children, 68А Leningradskaya St., Pesochny, S.-Petersburg, 197758



Yu. V. Dinikina
Almazov National Medical Research Centre, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Head of the Laboratory of Pediatric Neuro-Immuno-Oncology of the Pesonalized Medicine Centre and Head of the Department of Chemotherapy for Hematologic Diseases and Bone Marrow Transplantation for Children

2 Akkuratova St., S.-Petersburg, 197341



Yu. M. Zabrodskaya
Polenov Russian Neurosurgery Institute – Branch of the Almazov National Medical Research Center, Ministry of Health of Russia
Russian Federation

Dr. of Sci. (Med.), Head of the Research Laboratory for Pathomorphology of the Nervous System

12 Mayakovsky St., S.-Petersburg, 119014



V. A. Grigorenko
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation

Radiotherapist, Head of the Radiological Department of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov

23 Kashirskoe Shosse, Moscow, 115522



A. E. Druy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Head of the Laboratory of Molecular Oncology

1 Samory Mashela St., Moscow, 117997



L. A. Papusha
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation

Cand. of Sci. (Med.), Leading Researcher, Head of the Department of Optimization of CNS Tumor Therapy

1 Samory Mashela St., Moscow, 117997



References

1. WHO Classification of Tumours Editorial Board. Central nervous system tumours. [Electronic resource]: https://tumourclassifi cation. iarc.who.int/chapters/45. Lyon (France): International Agency for Research on Cancer; 2021. (WHO classifi cation of tumours series, 5th ed.; vol. 6).

2. Capper D., Jones D.T.W., Sill M., Hovestadt V., Schrimpf D., Sturm D., Koelsche C., Sahm F., Chavez L., Reuss D.E., Kratz A., Wefers A.K., Huang K., Pajtler K.W., Schweizer L., Stichel D., Olar A., Engel N.W., Lindenberg K., Harter P.N., Braczynski A.K., Plate K.H., Dohmen H., Garvalov B.K., Coras R., Hölsken A., Hewer E., Bewerunge-Hudler M., Schick M., Fischer R., Beschorner R., Schittenhelm J., Staszewski O., Wani K., Varlet P., Pages M., Temming P., Lohmann D., Selt F., Witt H., Milde T., Witt O., Aronica E., Giangaspero F., Rushing E., Scheurlen W., Geisenberger C., Rodriguez F.J., Becker A., Preusser M., Haberler C., Bjerkvig R., Cryan J., Farrell M., Deckert M., Hench J., Frank S., Serrano J., Kannan K., Tsirigos A., Brü ck W., Hofer S., Brehmer S., Seiz-Rosenhagen M., Hänggi D., Hans V., Rozsnoki S., Hansford J.R., Kohlhof P., Kristensen B.W., Lechner M., Lopes B., Mawrin C., Ketter R., Kulozik A., Khatib Z., Heppner F., Koch A., Jouvet A., Keohane C., Mü hleisen H., Mueller W., Pohl U., Prinz M., Benner A., Zapatka M., Gottardo N.G., Driever P.H., Kramm C.M., Mü ller H.L., Rutkowski S., von Hoff K., Frü hwald M.C., Gnekow A., Fleischhack G., Tippelt S., Calaminus G., Monoranu C.M., Perry A., Jones C., Jacques T.S., Radlwimmer B., Gessi M., Pietsch T., Schramm J., Schackert G., Westphal M., Reifenberger G., Wesseling P., Weller M., Collins V.P., Blü mcke I., Bendszus M., Debus J., Huang A., Jabado N., Northcott P.A., Paulus W., Gajjar A., Robinson G.W., Taylor M.D., Jaunmuktane Z., Ryzhova M., Platten M., Unterberg A., Wick W., Karajannis M.A., Mittelbronn M., Acker T., Hartmann C., Aldape K., Schü ller U., Buslei R., Lichter P., Kool M., Herold-Mende C., Ellison D.W., Hasselblatt M., Snuderl M., Brandner S., Korshunov A., von Deimling A., Pfi ster S.M. DNA methylation-based classifi cation of central nervous system tumours. Nature. 2018;555(7697):469–74. doi: 10.1038/nature26000.

3. Capper D., Stichel D., Sahm F., Jones D.T.W., Schrimpf D., Sill M., Schmid S., Hovestadt V., Reuss D.E., Koelsche C., Reinhardt A., Wefers A.K., Huang K., Sievers P., Ebrahimi A., Schöler A., Teichmann D., Koch A., Hänggi D., Unterberg A., Platten M., Wick W., Witt O., Milde T., Korshunov A., Pfi ster S.M., von Deimling A. Practical implementation of DNA methylation and copynumber-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol. 2018;136(2):181–210. doi: 10.1007/s00401-018-1879-y.

4. Ryzhova M.V., Telysheva E.N., Shaikhaev E.G., Starovoitov D.V., Kotelnikova A.O., Galstyan S.A., Okonechnikov K.V. Current diagnostic methods in molecular classifi cation of brain tumors at the Burdenko Neurosurgical Center. Zhurnal Voprosy Neirokhirurgii Imeni N.N. Burdenko = Burdenko’s Journal of Neurosurgery. 2021;85(6):98–101. (In Russ.). doi: 10.17116/neiro20218506198.

5. Ryzhova M.V., Galstyan S.A., Telysheva E.N. Significance of DNA methylation assessment in the morphological diagnosis of brain tumours. Arkhiv patologii = Pathology Archive. 2022;84(3):65–75. (In Russ.). doi: 10.17116/patol20228403165.

6. Sievers P., Henneken S.C., Blume C., Sill M., Schrimpf D., Stichel D., Okonechnikov O., Reuss D.E., Benzel J., Maa K.K., Kool M., Sturm D., Zheng T., Ghasemi D.R., Kohlhof-Meinecke P., Cruz O., Suol M., Lavarino C., Ruf V., Boldt H.B., Pags M., Pouget C., Schweizer L., Kranendonk M.E.G., Akhtar N., Bunkowski S., Stadelmann C., Schü ller U., Mueller W.C., Dohmen H., Acker T., Harter P.N., Mawrin C., Beschorner R., Brandner S., Snuderl M., Abdullaev Z., Aldape K., Gilbert M.R., Armstrong T.S., Ellison D.W., Capper D., Ichimura K., Reifenberger G., Grundy R.G., Jabado N., Krskova L., Zapotocky M., Vicha A., Varlet P., Wesseling P., Rutkowski S., Korshunov A., Wick W., Pfi ster S.M., Jones D.T.W., von Deimling A., Pajtler K.W., Sahm F. Recurrent fusions in PLAGL1 defi ne a distinct subset of pediatric-type supratentorial neuroepithelial tumors. Acta Neuropathol. 2021;142:827–39. doi: 10.1007/s00401-021-02356-6.

7. Alhalabi K.T., Stichel D., Sievers P., Peterzie H., Sommerkamp A.C., Sturm D., Wittmann A., Sill M., Jager N., Beck P., Pajtler K.W., Snuder M., Jour G., Delorenzo M., Martin A.M., Levy A., Dalvi N., Hansford J.R., Gottardo N.G., Uro-Coste E., Maurage C.-A., Godfraind C., Fanny Vandenbos F., Pietsch T., Kramm C., Filippidou M., Kattamis A., Jones C., Ora I., Mikkelsen T.S., Zapotocky M., Sumerauer D., Scheie D., McCabe M., Wesseling P., Tops B.B.J., Kranendonk M.E.G., Karajannis M.A., Bouvier N., Papaemmanuil E., Dohmen H., Acker T., von Hoff K., Schmid S., Miele E., Filipski K., Kitanovski L., Krskova L., Gojo J., Haberler C., Alvaro F., Ecker J., Selt F., Milde T., Witt O., Oehme I., Kool M., von Deimling A., Korshunov A., Pfi ster S.M., Sahm F., Jones D.T.W. PATZ1 fusions defi ne a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol. 2021;142:841–57. doi: 10.1007/s00401-021-02354-8.

8. Roosen M., Odé Z., Bunt J., Kool M. The oncogenic fusion landscape in pediatric CNS neoplasms. Acta Neuropathol. 2022;143(4):427–51. doi: 10.1007/s00401-022-02405-8.

9. Okonechnikov K.V., Ryzhova M.V., Galstyan S.A., Telysheva E.N. Application of high throughput sequencing in pediatric neurooncology. Arkhiv patologii = Pathology Archive. 2022;84(2):58 63. (In Russ.). doi: 10.17116/patol20228402158.

10. Capper D., Reifenberger G., French P.J., Schweizer L., Weller M., Touat M., Niclou S.P., Euskirchen P., Haberler C., Hegi M.E., Brandner S., Le Rhun E., Rudà R., Sanson M., Tabatabai G., Sahm F., Wen P.Y., Wesseling P., Preusser M., van den Bent M.J. EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection. Neuro Oncol. 2023;25(5):813–26. doi: 10.1093/neuonc/noad008.

11. Petrova E.I., Galstyan S.A., Telysheva E.N., Ryzhova M.V. Visualization of DNA methylation profiling data as a quality control tool for molecular classifi cation of CNS tumors. Rossiiskii neirokhirurgicheskii zhurnal imeni professora A.L. Polenova = Russian Neurosurgical Journal named after prof. A.L. Polenov. 2022;14(4):64–70. (In Russ.) doi: 10.56618/20712693_2022_14_4_64..

12. Kobiakov G.L., Absaliamova O.V., Poddubskiy A.A., Lodygina K.S., Kobyakova E.A. The 2016 WHO classifi cation of primary central nervous system tumors: a clinician’s view. Zhurnal Voprosy Neirokhirurgii Imeni N.N. Burdenko = Burdenko’s Journal of Neurosurgery. 2018;88(3):88 96. (In Russ.). doi: 10.17116/neiro201882388.

13. Dinikina Yu.V., Belogurova M.B. Major features of the 2021 WHO Classification of Tumors of the Central Nervous System: clinician’s view. Rossiyskiy zhurnal personalizirovannoy meditsiny = Russian Journal for Personalized Medicine. 2022;2(4):77–90. (In Russ.). doi: 10.18705/2782-3806-2022-2-4-77-90.


Review

For citations:


Ryzhova M.V., Olkhova L.V., Shishkina L.V., Golanov A.V., Zheludkova O.G., Kumirova E.V., Kislyakov A.N., Skobeev D.A., Belogurova M.B., Dinikina Yu.V., Zabrodskaya Yu.M., Grigorenko V.A., Druy A.E., Papusha L.A. The principles of therapy for modern diagnosis of brain tumors in children, which determine the prescription of the drugs. Russian Journal of Pediatric Hematology and Oncology. 2023;10(2):71-76. (In Russ.) https://doi.org/10.21682/2311-1267-2023-10-2-71-76

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ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
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