Preview

Российский журнал детской гематологии и онкологии (РЖДГиО)

Расширенный поиск

ПЕРВИЧНОЕ РЕЗИСТЕНТНОЕ ТЕЧЕНИЕ И РЕЦИДИВЫ ЛИМФОМЫ ХОДЖКИНА. ПРЕДОТВРАТИМЫЕ ПОТЕРИ ПРИ «САМОМ ИЗЛЕЧИМОМ» ГЕМОБЛАСТОЗЕ

https://doi.org/10.17650/2311-1267-2015-2-2-60-71

Полный текст:

Аннотация

В отличие от большинства злокачественных опухолей при лимфоме Ходжкина (ЛХ) возможность излечения сохраняется и у больных, опухоли которых не ответили на терапию 1-й линии (первичная резистентность или рецидив заболевания). В настоящее время стандартным методом лечения этих пациентов является высокодозная химиотерапия с трансплантацией аутологичных клеток предшественников гемопоэза (ТКПГ). Однако в РФ этот метод лечения используется значимо реже, чем в развитых странах мира, что обусловлено дефицитом доступных трансплантационных мощностей. Невозможность проведения ТКПГ всем пациентам, нуждающимся в ней, негативно сказывается на общей результативности лечения ЛХ, что требует поиска факторов, позволяющих оптимизировать отбор больных для выполнения ТКПГ. Однако анализ результатов зарубежных и отечественных исследований свидетельствует о том, что единственным фактором, позволяющим адекватно проводить отбор больных на проведение ТКПГ, является ответ опухоли на индукционную терапию (пациенты, находящиеся вне состояния ремиссии, получать ТКПГ не должны). Остальные факторы (вариант течения болезни, проведение терапии 2-й линии в анамнезе) не обладают достаточной степенью надежности для принятия решения об отказе в выполнении ТКПГ. Таким образом, все пациенты, у которых в результате проведения индукционной терапии достигнута ремиссия, должны рассматриваться как кандидаты на выполнение ТКПГ, а единственным способом предотвращения гибели больных с рецидивами и первично-резистентным течением ЛХ в РФ является увеличение трансплантационной активности (количества трансплантационных центров).

Об авторе

Н. В. Жуков
ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России; Россия, 117198, Москва, ул. Саморы Машела, 1 ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России; Россия, 117997, Москва, ул. Островитянова, 1
Россия


Список литературы

1. DeVita V. T. Jr, Simon R. M., Hubbard S. M. et al. Curability of advanced Hodgkin,s disease with chemotherapy: long-term follow-up of MOPP-treated patients at the National Cancer Institute. Ann Intern Med 1980;92(5):587–95.

2. Diehl V., Franklin J., Pfreundschuh M. et al. Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin,s disease. N Engl J Med 2003;348(24):2386–95.

3. Engert A., Diehl V., Franklin J. et al. Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin,s lymphoma: 10 years of follow-up of the GHSG HD9 study. J Clin Oncol 2009;27(27):4548–54.

4. Kuruvilla J., Keating A., Crump M. How I treat relapsed and refractory Hodgkin lymphoma. Blood 2011;117(16):4208–17.

5. Federico M., Luminari S., Iannitto E. et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin,s lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. J Clin Oncol 2009;27(5):805–11.

6. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62(1):10–29.

7. Аксель Е. М., Давыдов М. И. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2009 г. Вестник РОНЦ им. Н. Н. Блохина РАМН 2011;22(3 приложение 1). [Axel E. M., Davydov M. I. Cancer statistics in Russia and CIS in 2009. Vestnik RONC im. N. N. Blokhina RAMN = Journal of N. N. Blokhin Russian Cancer Research Center RAMS 2011;22(3 Suppl 1). (In Russ.)].

8. Богатырева Т., Столбовой А., Копп М. и др. Лимфома Ходжкина: трудности

9. на пути реализации стандартов лечения и их преодоление. Врач 2011;12:34–40. [Bogatyreva T., Stolbovoy A., Copp M. et al. Hodgkin,s lymphoma: difficulties encountered in realizing the treatment standards and their overcoming. Vrach = Physician 2011;12:34–40. (In Russ.)].

10. Демина Е. А. Дискуссионные вопросы лечения распространенных стадий лимфомы Ходжкина. Злокачественные опухоли 2013;111(4):18–22. [Demina E. A. Discussion questions treat for advanced stages of Hodgkin,s lymphoma. Zlokachestvennye opukholi = Malignant Tumours 2013;111(4):18–22. (In Russ.)].

11. Hoppe R. T., Advani R. H., Ai W. Z. et al.; National Comprehensive Cancer Network. Hodgkin lymphoma, version 2.2012 featured updates to the NCCN guidelines. J Natl Compr Canc Netw 2012;10(5):589–97.

12. Engert A., Eichenauer D. A., Dreyling M.; ESMO Guidelines Working Group. Hodgkin,s lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21 Suppl 5: v168–71.

13. Collins G. P., Parker A. N., Pocock C. et al.; British Society of Blood and Marrow Transplantation. Guideline on the management of primary resistant and relapsed classical Hodgkin lymphoma. Br J Haematol 2014;164(1):39–52.

14. Linch D. C., Winfield D., Goldstone A. H. et al. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin,s disease: results of a BNLI randomised trial. Lancet 1993;341(8852):1051–4.

15. Schmitz N., Pfistner B., Sextro M. et al.; German Hodgkin,s Lymphoma Study Group; Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin,s disease:

16. a randomised trial. Lancet 2002;359(9323):2065–71.

17. Schmitz N., Haverkamp H., Josting A. et al. Long term follow up in relapsed Hodgkin,s disease (HD): updated results of the HD-R1 study comparing conventional chemotherapy (cCT) to high-dose chemotherapy (HDCT) with autologous haemopoetic stem cell transplan tation (ASCT) of the German Hodgkin Study Group (GHSG) and the Working Party Lymphoma of the European Group for Blood and Marrow Transplantation (EBMT). J Clin Oncol 2005;23 Suppl 16:6508.

18. Passweg J. R., Baldomero H., Bregni M. et al.; European Group for Blood and Marrow Transplantation. Hematopoietic SCT in Europe: data and trends in 2011. Bone Marrow Transplant 2013;48(9):1161–7.

19. Brice P., Bouabdallah R., Moreau P. et al. Prognostic factors for survival after high-dose therapy and autologous stem cell transplantation for patients with relapsing Hodgkin,s disease: analysis of 280 patients from the French registry. Société Française de Greffe de Moëlle. Bone Marrow Transplant 1997;20(1):21–6.

20. Sweetenham J. W., Taghipour G., Milligan D. et al. High-dose therapy and autologous stem cell rescue for patients with Hodgkin,s disease in first relapse after chemotherapy: results from the EBMT. Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 1997;20(9):745–52.

21. Yuen A. R., Rosenberg S. A., Hoppe R. T. et al. Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin,s disease. Blood 1997;89(3):814–22.

22. Rancea M., Skoetz N., Monsef I. et al. Fourteenth biannual report of the Cochrane Haematological Malignancies Group – focus on autologous stem cell transplantation

23. in hematological malignancies. J Natl Cancer Inst 2012;104(14):NP.

24. Rancea M., Monsef I., von Tresckow B. et al. High-dose chemotherapy followed

25. by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma. Cochrane Database Syst Rev 2013;6:CD009411.

26. Schellong G., Dörffel W., Claviez A. et al. Salvage therapy of progressive and recurrent Hodgkin,s disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group. J Clin Oncol 2005;23(25):6181–9.

27. Josting A., Franklin J., May M. et al. New prognostic score based on treatment outcome of patients with relapsed Hodgkin,s lymphoma registered in the database of the German Hodgkin,s lymphoma study group. J Clin Oncol 2002;20(1):221–30.

28. Salvagno L., Sorarù M., Aversa S. M. et al. Late relapses in Hodgkin,s disease: Outcome of patients relapsing more than twelve months after primary chemotherapy. Ann Oncol 1993;4(8):657–62.

29. Viviani S., Santoro A., Negretti E. et al. Salvage chemotherapy in Hodgkin,s disease. Results in patients relapsing more than twelve months after first complete remission. Ann Oncol 1990;1(2):123–7.

30. Филатова Л. В., Тарасенкова А. А., Гершанович М. Л., Семиглазова Т. Ю. Первично-рефрактерные формы лимфомы Ходжкина. Вопросы онкологии 2012;58(5):627–38. [Filatova L. V., Tarasenkova A. A., Gershanovich M. L., Semiglazova T. Yu. Primary refractory forms of Hodgkin,s lymphoma. Voprosy onkologii = Issues of Oncology 2012;58(5):627–38.

31. (In Russ.)].

32. Богатырева Т., Павлов В., Шкляев С. Рецидивы лимфомы Ходжкина: возможности продления жизни без высокодозной химиотерапии. Врач 2012;11:5–8. [Bogatyreva T., Pavlov V., Shklyaev S. Recurrent Hodgkin,s lymphoma: possibilities for prolonging life without high-dose chemotherapy. Vrach = Physician 2012; 11:5–8. (In Russ.)].

33. Sureda A., Arranz R., Iriondo A. et al. Autologous stem-cell transplantation for Hodgkin,s disease: results and prognostic factors in 494 patients from the Grupo Español de Linfomas/Transplante Autólogo de Médula Osea Spanish Cooperative Group. J Clin Oncol 2001;19(5):1395–404.

34. Жуков Н. В., Усс А. Л., Миланович Н. Ф. и др. Оптимальные сроки проведения аутологичной трансплантации клеток предшественников гемопоэза при неблагоприятном течении лимфомы Ходжкина. Зарубежные рекомендации и отечественная практика (часть II). Онкогематология 2014;3:32–40. [Zhukov N. V., Uss A. L., Milanovich N. F. et al. The optimal time for hematopoietic stem cell translantation for Hodgkin,s lymphoma. International guidelines and real practic in Russia and former USSR countries (Part II). Onkogematologiya = Oncohematology 2014;3:32–40. (In Russ.)].

35. Daw S., Wynn R., Wallace H. Manage ment of relapsed and refractory classical Hodgkin lymphoma in children and adoles cents. Br J Haematol 2011;152(3):249–60.

36. To L. B., Levesque J. P., Herbert K. E. How I treat patients who mobilize hematopoietic stem cells poorly. Blood 2011;118(17):4530–40.

37. Jantunen E., Kuittinen T., Nousiainen T. Is chemotherapy scoring useful to predict progenitor cell mobilisation in patients with non-Hodgkin,s lymphoma? Bone Marrow Transplant 2003;32(6):569–73.

38. Жуков Н. В., Усс А. Л., Миланович Н. Ф. и др. Оптимальные сроки проведения аутологичной трансплантации клеток предшественников гемопоэза при неблагоприятном течении лимфомы Ходжкина. Зарубежные рекомендации и отечественная практика. Онкогематология 2014;2:37–44. [Zhukov N. V., Uss A. L., Milanovich N. F. et al. The optimal time for autologous hematopoietic progenitor cell transplantation during treatment of Hodgkin,s lymphoma. Foreign recommendations and russian experience. Onkogematologiya = Oncohematology 2014;2:37–44. (In Russ.)].

39. Bonfante V., Santoro A., Viviani S. et al. Outcome of patients with Hodgkin,s disease failing after primary MOPP-ABVD. J Clin Oncol 1997;15(2):528–34.

40. Sweetenham J. W., Carella A. M., Taghipour G. et al. High-dose therapy and autologous stem-cell transplantation for adult patients with Hodgkin,s disease who do not enter remission after induction chemotherapy: results in 175 patients reported to the European Group

41. for Blood and Marrow Transplantation. Lymphoma Working Party. J Clin Oncol 1999;17(10):3101–9.

42. Lazarus H. M., Rowlings P. A., Zhang M. J. et al. Autotransplants for Hodgkin,s disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry. J Clin Oncol 1999;17(2):534–45.

43. Reece D. E., Barnett M. J., Shepherd J. D. et al. High-dose cyclophosphamide, carmustine (BCNU), and etoposide (VP16-213) with or without cisplatin (CBV +/– P) and autologous transplantation for patients with Hodgkin,s disease who fail to enter a complete remission after combination chemotherapy. Blood 1995;86(2):451–6.

44. Horning S. J., Chao N. J., Negrin R. S. et al. High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin,s disease: analysis of the Stanford University results and prognostic indices. Blood 1997;89(3):801–13.

45. Gianni A. M., Siena S., Bregni M. et al. High-dose sequential chemo-radiotherapy with peripheral blood progenitor cell support for relapsed or refractory Hodgkin,s disease – a 6-year update. Ann Oncol 1993;4(10):889–91.

46. Josting A., Rueffer U., Franklin J. et al. Prognostic factors and treatment outcome

47. in primary progressive Hodgkin lymphoma: a report from the German Hodgkin Lymphoma Study Group. Blood 2000;96(4):1280–6.

48. Smith S. D., Moskowitz C. H., Dean R. et al. Autologous stem cell transplant for early relapsed/refractory Hodgkin lymphoma: results from two transplant centres. Br J Haematol 2011;153(3):358–63.

49. Moskowitz C. H., Kewalramani T., Nimer S. D. et al. Effectiveness of high dose chemoradiotherapy and autologous stem cell transplantation for patients with biopsy-proven primary refractory Hodgkin,s disease. Br J Haematol 2004;124(5):645–52.

50. Puig N., Pintilie M., Seshadri T. et al. Different response to salvage chemotherapy but similar post-transplant outcomes in patients with relapsed and refractory Hodgkin,s lymphoma. Haematologica 2010;95(9):1496–502.

51. Жуков Н. В., Румянцев А. Г., Усс А. Л. и др. Высокодозная химиотерапия

52. с аутологичной трансплантацией гемопоэтических стволовых клеток при первичной резистентности и резистентных рецидивах лимфомы Ходжкина. Существует ли равное право на жизнь? Клиническая онкогематология. Фундаментальные исследования и клиническая практика 2014;7(3):317–26. [Zhukov N. V., Rumyantsev A. G., Uss A. L. et al. High-dose chemotherapy and autologous stem cell transplantation relapsed/refractory Hodgkin,s lymphoma. Is there an equal right to life? Klinicheskaya onkogematologiya. Fundamentalnye issledovaniya i klinicheskaya praktika = Clinical Oncohematology. Basic Research

53. and Clinical Practice 2014;7(3):317–26. (In Russ.)].

54. Fermé C., Mounier N., Diviné M. et al. Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin,s disease in relapse or failure after initial chemotherapy: results of the Groupe d,Etudes des Lymphomes de l,Adulte H89 Trial. J Clin Oncol 2002;20(2):467–75.

55. Czyz J., Dziadziuszko R., Knopinska-Postuszuy W. et al. Outcome and prognostic factors in advanced Hodgkin,s disease treated with high-dose chemotherapy and autologous stem cell transplantation: a study of 341 patients. Ann Oncol 2004;15(8):1222–30.

56. Stoneham S., Ashley S., Pinkerton C. R. et al. United Kingdom Children,s Cancer Study Group. Outcome after autologous hemopoietic stem cell transplantation in relapsed or refractory childhood Hodgkin disease. J Pediatr Hematol Oncol 2004;26(11):740–5.

57. Sureda A., Constans M., Iriondo A. et al. Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin,s lymphoma autografted after a first relapse. Ann Oncol 2005;16(4):625–33.

58. Moskowitz C. H., Nimer S. D., Zelenetz A. D. et al. A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model. Blood 2001;97(3):616–23.

59. Nademanee A., O,Donnell M. R., Snyder D. S. et al. High-dose chemotherapy with or without total body irradiation followed by autologous bone marrow and/or peripheral blood stem cell transplantation for patients with relapsed and refractory Hodgkin,s disease: results in 85 patients with analysis of prognostic factors. Blood 1995;85(5):1381–90.

60. Brice P., Divine M., Simon D. et al. Feasibility of tandem autologous stem-cell transplantation (ASCT) in induction failure or very unfavorable (UF) relapse from Hodgkin,s disease (HD). Ann Oncol 1999;10(12):1485–8.

61. Morschhauser F., Brice P., Fermé C. et al. Risk-adapted salvage treatment with single

62. or tandem autologous stem-cell transplantation for first relapse/refractory Hodgkin,s lymphoma: results of the prospective multicenter H96 trial by the GELA/ SFGM study group. J Clin Oncol 2008;26(36):5980–7.

63. Moskowitz A. J., Yahalom J., Kewalramani T. et al. Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma. Blood 2010;116(23):4934–7.

64. Bartlett N. L. Therapies for relapsed Hodgkin lymphoma: transplant

65. and non-transplant approaches including immunotherapy. Hematology Am Soc Hematol Educ Program 2005:245–51.

66. Claviez A., Sureda A., Schmitz N. Haematopoietic SCT for children and adolescents with relapsed and refractory Hodgkin,s lymphoma. Bone Marrow Transplant 2008;42:S16–24.

67. Rosenberg S. A., Boiron M., DeVita V.T. et al. Report of the committee on Hodgkin,s disease staging procedures. Cancer Res 1971;31(11):1862–3.

68. Lister T. A., Crowther D., Sutcliffe S. B. et al. Report of a committee convened

69. to discuss the evaluation and staging of patients with Hodgkin,s disease: Cotswolds meeting. J Clin Oncol 1989;7(11):1630–6.

70. Cheson B. D., Fisher R. I., Barrington S. F. et al.; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin,s Study Group; Japanese Lymphoma Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 2014;32(27):3059–68.

71. Canellos G. P. Residual mass in lymphoma may not be residual disease. J Clin Oncol 1988;6(6):931–3.

72. Radford J. A., Cowan R. A., Flanagan M. et al. The significance of residual mediastinal abnormality on the chest radiograph following treatment for Hodgkin,s disease. J Clin Oncol 1988;6(6):940–6.

73. Jabbour E., Hosing C., Ayers G. et al. Pretransplant positive positron emission tomography/gallium scans predict poor outcome in patients with recurrent/refractory Hodgkin lymphoma. Cancer 2007;109(12):2481–9.

74. Colpo A., Hochberg E., Chen Y. B. Current status of autologous stem cell transplantation in relapsed and refractory Hodgkin,s lymphoma. Oncologist 2012;17(1):80–90.

75. Quddus F., Armitage J. O. Salvage therapy for Hodgkin,s lymphoma. Cancer J 2009;15(2):161–3.

76. Mendler J. H., Friedberg J. W. Salvage therapy in Hodgkin,s lymphoma. Oncologist 2009;14(4):425–32.

77. Martín A., Fernández-Jiménez M. C., Caballero M. D. et al. Long-term follow-up in patients treated with Mini-BEAM

78. as salvage therapy for relapsed or refractory Hodgkin,s disease. Br J Haematol 2001;113(1):161–71.

79. Fernández-Jiménez M. C., Canales M. A., Ojeda E. et al. Salvage chemotherapy

80. with mini-BEAM for relapsed or refractory Hodgkin,s disease prior to autologous peripheral blood stem cell transplantation. Haematologica 1999;84(11):1007–11.

81. Aparicio J., Segura A., Garcerá S. et al. ESHAP is an active regimen for relapsing Hodgkin,s disease. Ann Oncol 1999;10(5):593–5.

82. Rodriguez J., Rodriguez M. A., Fayad L. et al. ASHAP: a regimen for cytoreduction of refractory or recurrent Hodgkin,s disease. Blood 1999;93(11):3632–6.

83. Suyanı E., Sucak G. T., Akı Ş. Z. et al. Gemcitabine and vinorelbine combination

84. is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT. Ann Hematol 2011;90(6):685–91.

85. Santoro A., Magagnoli M., Spina M. et al. Ifosfamide, gemcitabine,

86. and vinorelbine: a new induction regimen for refractory and relapsed Hodgkin,s lymphoma. Haematologica 2007;92(1): 35–41.

87. Dreger P., Klöss M., Petersen B. et al. Autologous progenitor cell transplantation: prior exposure to stem. Blood 1995;86(10):3970–8.

88. Kuruvilla J., Nagy T., Pintilie M. et al. Similar response rates and superior early progression-free survival with gemcitabine, dexamethasone, and cisplatin salvage therapy compared with carmustine, etoposide, cytarabine, and melphalan salvage therapy prior to autologous stem cell transplantation for recurrent or refractory Hodgkin lymphoma. Cancer 2006;106(2):353–60.

89. Shea T. C., Beaven A. W., Moore D. T. et al. Sequential high-dose ifosfamide, carboplatin and etoposide with rituximab for relapsed Hodgkin and large B-cell non-Hodgkin lymphoma: increased toxicity without improvement in progression-free survival. Leuk Lymphoma 2009;50(5):741–8.

90. Josting A., Müller H., Borchmann P. et al. Dose intensity of chemotherapy in patients with relapsed Hodgkin,s lymphoma. J Clin Oncol 2010;28(34):5074–80.


Для цитирования:


Жуков Н.В. ПЕРВИЧНОЕ РЕЗИСТЕНТНОЕ ТЕЧЕНИЕ И РЕЦИДИВЫ ЛИМФОМЫ ХОДЖКИНА. ПРЕДОТВРАТИМЫЕ ПОТЕРИ ПРИ «САМОМ ИЗЛЕЧИМОМ» ГЕМОБЛАСТОЗЕ. Российский журнал детской гематологии и онкологии (РЖДГиО). 2015;2(2):60-71. https://doi.org/10.17650/2311-1267-2015-2-2-60-71

For citation:


Zhukov N.V. PRIMARY RESISTANT COURSE AND RECURRENCE OF THE HODGKIN,S LYMPHOMA. PREVENTABLE LOSSES AT “MOST RECOVERABLE” HEMOBLASTOSIS. Russian Journal of Pediatric Hematology and Oncology. 2015;2(2):60-71. (In Russ.) https://doi.org/10.17650/2311-1267-2015-2-2-60-71

Просмотров: 550


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)