CRANIAL NEUROPATHY, INDUCED BY VINCRISTINE ADMINISTRATION AT A CHILD SUFFERING WITH EWING,S SARCOMA
https://doi.org/10.17650/2311-1267-2015-2-2-85-88
Abstract
The pharmaceutical neuropathy is the most often complication from the part of the nervous system at children, receiving the therapy with chemical therapeutic agents. Among most unfavorable substance vincristine (VNC) is highlighted, which neurotoxicity often causes the dose reduction or its full withdrawal from the used treatment protocol. The clinical pattern of the VNC induced neuropathy in most cases is represented by the lesion of nerve fibers of upper and lower extremities with the development of symptoms of the peripheral polyneuropathy. In more rare cases VNC causes the lesion of axons of cranial and brain nerves. The given clinical case describes the monitoring of the cranial neuropathy, the lesion of the oculomotor nerve, presented by bilateral ptosis at a child with Ewing,s sarcoma, treated by СWS-2009 protocol.
Keywords
vincristine,
children,
neuropathy,
Ewing,s sarcoma,
treatment,
observation,
protocol,
neurotoxicity,
tumor
About the Author
O. B. Malevich
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117198, Russia
Russian Federation
Russian Federation
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Review
For citations:
Malevich O.B. CRANIAL NEUROPATHY, INDUCED BY VINCRISTINE ADMINISTRATION AT A CHILD SUFFERING WITH EWING,S SARCOMA. Russian Journal of Pediatric Hematology and Oncology. 2015;2(2):85-88. (In Russ.) https://doi.org/10.17650/2311-1267-2015-2-2-85-88
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