Using a low-volume method of extracorporeal photochemotherapy. Description of clinical cases
https://doi.org/10.21682/2311-1267-2024-11-4-98-103
Abstract
Extracorporeal photopheresis (ECP) has proven effective in the treatment of several diseases, including acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. In its standard version, ECP requires leukapheresis to obtain a fraction of mononuclear cells. The possibility of using leukapheresis is limited by the requirements for vascular access and the somatic status of the patient.
In the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia was developed a new ECP method that does not require leukapheresis. This paper presents a description of two clinical cases of severe refractory GVHD treated by micro-ECP.
About the Authors
I. B. Kumukova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; “Kommunarka Moscow Multidisciplinary Clinical Center” of the Department
of Health in Moscow”; Russian Medical Academy of Continuous
Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Researcher; Head of the Transfusion Department; Docent of the Department of Hematology and Transfusiology named after Academicians I.A. Kassirsky and A.I. Vorobyov
1 Samory Mashela St., Moscow, 117997
8 Sosensky Stan St., Kommunarka, Moscow, 108814
Bldg. 1, 2/1 Barrikadnaya St., Moscow, 125993
E. E. Kurnikova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Transfusiologist
1 Samory Mashela St., Moscow, 117997
P. E. Trakhtman
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Transfusiology Department of the Harvesting and Processing of Hemopoietic Stem Cells; Professor of the Department of Hematology and Transfusiology named after Academicians I.A. Kassirsky and A.I. Vorobyov
1 Samory Mashela St., Moscow, 117997
Bldg. 1, 2/1 Barrikadnaya St., Moscow, 125993
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Review
For citations:
Kumukova I.B., Kurnikova E.E., Trakhtman P.E. Using a low-volume method of extracorporeal photochemotherapy. Description of clinical cases. Russian Journal of Pediatric Hematology and Oncology. 2024;11(4):98-103. (In Russ.) https://doi.org/10.21682/2311-1267-2024-11-4-98-103
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