Первичные злокачественные опухоли легких у детей (обзор литературы)

Первичные злокачественные опухоли легких – крайне редко встречающаяся в детском и подростковом возрасте патология.

Цель данной публикации – обзор наиболее полных и весомых ретроспективных исследований, посвященных данной нозологии, изучение эпидемиологии, клинической картины и методов лечения, а также оценка прогноза по заболеванию в зависимости от гистологического типа опухоли.

1. Hartman G.E., Shochat S.J. Primary pulmonary neoplasms of childhood: a review. Ann Thorac Surg. 1983;36(1):108–19. doi: 10.1016/s0003-4975(10)60664-9.

2. Cohen M.C., Kaschula R.O. Primary pulmonary tumors in childhood: a review of 31 years’ experience and the literature. Pediatr Pulmonol. 1992;14(4):222–32. doi: 10.1002/ppul.1950140405.

3. Dishop M.K., Kuruvilla S. Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children’s hospital. Arch Pathol Lab Med. 2008;132(7):1079–103. doi: 10.5858/2008-132-1079-PAMLTI.

4. An J., Han J., Ahn K.H., Kim J., Choi Y.S. Primary neoplasms of the lung in children and adolescents: 22 cases from a single institute. J Lung Cancer. 2009;8(2):103–10. doi: 10.6058/jlc.2009.8.2.103.

5. Weldon C.B., Shamberger M.D. Pediatric pulmonary tumors: primary and metastatic. Semin Pediatr Surg. 2008;17:17–29. doi: 10.1053/j.sempedsurg.2007.10.004.

6. Yu D.C., Grabowski M.J., Kozakewich H.P., Perez-Atayde A.R., Voss S.D., Shamberger R.C., Weldon C.B. Primary lung tumors in children and adolescents: a 90-year experience. J Pediatr Surg. 2010;45:1090–5. doi: 10.1016/j.jpedsurg.2010.02.070.

7. Indolfi P., Casale F., Carli M., Bisobno G., Ninfo V., Cecchetto G., Bagnulo S., Santoro N., Giuliano M., Di Tullio M.T. Pleuropulmonary blastoma: management and prognosis of 11 cases. Cancer. 2000;89:1396–401. doi: 10.1002/1097-0142(20000915)89:63.0.CO;2-2.

8. Dehner L.P., Tazelaar H.D., Manabe T. Pleuropulmonary blastoma. In: World Health Organization classifi cation of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Travis W.D., Brambilla E., Muller-Hermelink H.K., Harris C.C. (eds.). IARC Press, Lyon, 2004. Pp. 99–100.

9. Büyükavc M., Altas S., Salman B., Eren S. An aggressive childhood tumor mimicking pleural empyema: pleuropulmonary blastoma. J Pediatr Hematol Oncol. 2006;28(4):257–9. doi: 10.1097/01.mph.0000212917.24051.6f.

10. Neville H.L., Hogan A.R., Zhuge Y., Perez E.A., Cheung M.C., Koniaris L.G., Thompson W.R., Sola J.E. Incidence and outcomes of malignant pediatric neoplasms. J Surg Res. 2009;156(2):224–30. doi: 10.1016/j.jss.2009.03.100.

11. Abele M., Voggel S., Bremensdorfer C., Spix C., Erdmann F., Kuhlen M., Redlich A., Ebinger M., Lang P., Schneider D.T., Brecht I.B. Incidences and characteristics of primary lung malignancies in childhood in Germany: An analysis of population-based data from German cancer registries. Pediatr Blood Cancer. 2022;69(9):e29744. doi: 10.1002/pbc.29744.

12. Ferrari A., Brecht I.B., Gatta G., Schneider D.T., Orbach D., Cecchetto G., Godzinski J., Reguerre Y., Bien E., Stachowicz-Stencel T., Ost M., Magni C., Kearns P., Vassal G., Massimino M., Biondi A., Bisogno G., Trama A. Defi ning and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors. Eur J Cancer. 2019;110:120–6. doi: 10.1016/j.ejca.2018.12.031.

13. Rojas Y., Shi Y.X., Zhang W., Beierle E.A., Doski J.J., Goldfarb M., Goldin A.B., Gow K.W., Langer M., Vasudevan S.A., Nuchtern J.G. Primary malignant pulmonary tumors in children: a review of the national cancer data base. J Pediatr Surg. 2015;50(6):1004–8. doi: 10.1016/j.jpedsurg.2015.03.032.

14. Smith N.J., Mukherjee D., Wang Y., Brazauskas R., Nelson A.A., Cortina C.S. Epidemiology and outcomes of primary pediatric lung malignancies: Updates from the SEER database. Am J Surg. 2021;222(4):861–6. doi: 10.1016/j.amjsurg.2021.01.037.

15. Demir H.A., Yalcin B., Ciftci A.O., Ciftci A.O., Orhan D., Varan A., Akyuz C., Kutluk T., Buyukpamukcu M. Primary pleuropulmonary neoplasms in childhood: fourteen cases from a single center. Asian Pac J Cancer Prev. 2011;12(2):543–7. PMID: 21545227.

16. Erdmann F., Kaatsch P., Grabow D., Spix C. German Childhood Cancer Registry – Annual Report 2019 (1980–2018). Institute of medical biostatistics, epidemiology and informatics (IMBEI) at the University Medical Center of the Johannes Gutenberg University Mainz. 2020;28.

17. Youlden D.R., Foresto S.A., Aitken J.F. Primary malignant lung tumors in children: a report from the Australian Childhood Cancer Registry, 1983–2015. Pediatr Pulmonol. 2020;55(3):719–22. doi: 10.1002/ppul.24636.

18. Hancock B.J., DiLorenzo M., Youssef S., Yazbeck S., Marcotte J.E., Collin P.P. Childhood primary pulmonary neoplasms. J Pediatr Surg. 1993;28:1133–6. doi: 10.1016/0022-3468(93)90147-d.

19. McCahon E. Lung tumours in children. Paediatr Respir Rev. 2006;7:191–6. doi: 10.1016/j.prrv.2006.05.002.

20. Lal D.R., Clark I., Shalkow J., Downey R.J., Shorter N.A., Klimstra D.S., La Quaglia M.P. Primary epithelial lung malignancies in the pediatric population. Pediatr Blood Cancer. 2005;45:683–6. doi: 10.1002/pbc.20279.

21. Wang L.T., Wilkins E.W., Bode H.H. Bronchial carcinoid tumors in pediatric patients. Chest. 1993;103(5):1426–8. doi: 10.1378/chest.103.5.1426.

22. Moraes T.J., Langer J.C., Forte V., Shayan K., Sweezey N. Pediatric pulmonary carcinoid: a case report and review of the literature. Pediatr Pulmonol. 2003;35:318–22. doi: 10.1002/ppul.10249.

23. Faurox B., Aynie V., Larroquet M., Boccon-Gibod L., Ducou le Pointe H., Tamalet A., Clement A. Carcinoid and mucoepidermoid bronchial tumors in children. Eur J Pediatr. 2005;164:748–52. doi: 10.1007/s00431-005-1740-x.

24. Welsh J.H., Maxson T., Jaksic I., Shahab I., Hicks J. Tracheobroncial mucoepidermoid carcinoma in childhood and adolescence: a case report and review of the literature. Int J Pediatr Otorhinolaryngol. 1998;45:265–73. doi: 10.1016/s0165-5876(98)00120-7.

25. Ramos S.G., Barbosa G.H., Tavora F.R., Jeudy J., Torres L.A.G.M., Tone L.G., Trad C.S. Bronchoalveolar carcinoma arising in a congenial pulmonary airway malformation in a child: case report with an update of this asso ciation. J Pediatr Surg. 2007;42:E1–4. doi: 10.1016/j.jpedsurg.2007.02.003.

26. West D., Nicholson A.G., Colquhoun I., Pollock J. Bronchoalveolar carcinoma in congenital cyst adenomatoid malformation of lung. Ann Thorac Surg. 2007;83:687–9. doi: 10.1016/j.athoracsur.2006.06.029.

27. Bartley T.D., Arean V.M. Intrapulmonary neurogenic tumors. J Thorac Cardiovasc Surg. 1965;50:114–23. PMID: 14313860.

28. Crist W.M., Raney R.B. Jr, Newton W., Lawrence W. Jr, Teff t M., Foulkes M.A. Intrathoracic soft tissue sarcomas in children. Cancer. 1982;50(3):598–604. doi: 10.1002/1097-0142(19820801)50:3<598::aidcncr2820500336>3.0.co;2-#.

29. Jimenez J.F., Uthman E.O., Townsend J.W., Gloster E.S., Seibert J.J. Primary bronchopulmonary leiomyosarcoma in childhood. Arch Pathol Lab Med. 1986;110(4):348–51. PMID: 3754125.

30. Pettinato G., Manivel J.C., Saldana M.J., Peyser J., Dehner L.P. Primary bronchopulmonary fi brosarcoma of childhood and adolescence: reassessment of a low-grade malignancy. Clinicopathologic study of fi ve cases and review of the literature. Hum Pathol. 1989;20(5):463–71. doi: 10.1016/0046-8177(89)90012-9.

31. Muwakkit S.A., Rodriguez-Galindo C., El Samra A.I., Khoury R., Akel S.R., Mroueh S., Razzouk B., Abboud M.R. Primary malignant peripheral nerve sheath tumor of the lung in a young child without neurofi bromatosis type 1. Pediatr Blood Cancer. 2006;47(5):636–8. doi: 10.1002/pbc.20787.

32. Ferrari A., Bisogno G., Alaggio R., Cecchetto G., Collini P., Rosolsen A., Meazza C., Indolfi P., Garaventa A., De Sio L., D’Angelo P., Tamaro P., Casanova M., Carli M. Synovial sarcoma of children and adolescents: the prognostic role of axial sites. Eur J Cancer. 2008;44(9):1202–9. doi: 10.1016/j.ejca.2008.03.016.

33. Balaji R., Kumar P., Garg I., Das K. Primary pulmonary rhabdomyosarcoma in a child. J Indian Assoc Pediatr Surg. 2017;22(1):57–9. doi: 10.4103/0971-9261.194629.

34. Wu X., Zhou C., Jin L., Liu H., Liu J., Zhao S. Primary pulmonary lymphoma in children. Orphanet J Rare Dis. 2019;14(1):35. doi: 10.1186/s13023-019-1009-5.

35. Oguz B., Ozcan H.N., Omay B., Ozgen B., Haliloglu M. Imaging of childhood infl ammatory myofi broblastic tumor. Pediatr Radiol. 2015;45(11):1672–81. doi: 10.1007/s00247-015-3377-x.

36. Travis W.D., Brambilla E., Nicholson A.G., Yatabe Y., Austin J.H.M., Beasley M.B., Chirieac L.R., Dacic S., Duhig E., Flieder D.B., Geisinger K., Hirsch F.H., Ishikawa Y., Kerr K.M., Noguchi M., Pelosi G., Powell C.A., Sound Tsao M., Wistuba I., WHO panel. The 2015 World Health Organization classifi cation of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classifi cation. J Thorac Oncol. 2015;10(9):1243–60. doi: 10.1097/JTO.0000000000000630.

37. Messinger Y.H., Stewart D.R., Priest J.R., Williams G.M., Harris A.K., Schultz K.A.P., Yang J., Doros L., Rosenberg P.S., Hill D.A., Dehner L.P. Pleuropulmonary blastoma: a report on 350 central pathology-confi rmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry. Cancer. 2015;121(2):276–85. doi: 10.1002/cncr.29032.

38. Gelinas J.F., Manoukian J., Cote A. Lung involvement in juvenile onset recurrent respiratory papillomatosis: a systematic review of the literature. Int J Pediatr Otorhinolaryngol. 2008;72(4):433–52. doi: 10.1016/j.ijporl.2007.12.003.

39. Casagrande A., Pederiva F. Association between congenital lung malformations and lung tumors in children and adults: a systematic review. J Thorac Oncol. 2016;11(11):1837–45. doi: 10.1016/j.jtho.2016.06.023.

40. Karatayli-Ozgursoy S., Bishop J.A., Hillel A., Akst L., Best S.R. Risk factors for dysplasia in recurrent respiratory papillomatosis in an adult and pediatric population. Ann Otol Rhinol Laryngol. 2016;125(3):235–41. doi: 10.1177/0003489415608196.

41. Mai P.L., Best A.F., Peters J.A., DeCastro R.M., Khincha P.P., Loud J.T., Bremer R.C., Rosenberg P.S., Savage S.A. Risks of fi rst and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li–Fraumeni syndrome cohort. Cancer. 2016;122(23):3673–81. doi: 10.1002/cncr.30248.

42. Niitu Y., Kubota H., Hasegawa S., Horikawa M., Komatsu S. Lung cancer (squamous cell carcinoma) in adolescence. Am J Dis Child. 1974;127:108–11. doi: 10.1001/archpedi.1974.02110200110017.

43. La Salle A.J., Andrassy R.J., Stanfor W. Bronchogenic squamous cell carcinoma in childhood: a case report. J Pediatr Surg. 1977;12:519–21. doi: 10.1016/0022-3468(77)90189-0.

44. Sharma R., Stein D., Khan W. Primary squamous cell carcinoma of the lung in a 7-year old boy: a case report. J Pediatr Hematol Oncol. 2011;33:e307–9. doi: 10.1097/MPH.0b013e31822bf5e2.

45. Longhi A., Bertoni F., Bacchini P., Albisinni U., Mercati U., Bacci G. Simultaneous osteosarcoma lung metastasis and second primary lung cancer. J Pediatr Hematol Oncol. 2004;26(7):457–61. doi: 10.1097/00043426-200407000-00013.

46. Holmqvist A.S., Chen Y., Berano Teh J.B., Sun C., Birch J.M., van des Bos C., Diller L.R., Dilley K., Ginsberg J., Martin L.T., Nagarajan R., Nathan P.C., Neglia J.P., Terenziani M., Tishler D., Meadows A.T., Robinson L.L., Oberlin O., Bhatia S. Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma identifi cation of high-risk populations to guide surveillance: a report from the Late Eff ects Study Group. Cancer. 2019;125(8):1373–83. doi: 10.1002/cncr.31807.

47. Giuseppucci C., Reusmann A., Giubergia V., Barrias C., Kruger A., Siminovich M., Botto H., Cadario M., Boglione M., Srtambach J., Barrenechea M. Primary lung tumors in children: 24 years of experience at a referral center. Pediatr Surg Int. 2016;32:451–7. doi: 10.1007/s00383-016-3884-3.

48. Lichtenberger J.P., Biko D.M., Carter B.W., Pavio M.A., Huppmann A.R., Chung E.M. Primary lung tumors in children: radiologic-pathology correlation. Radiographics. 2018;38(7):2151–72. doi: 10.1148/rg.2018180192.

49. Dahabreh J., Stathopouls G.P., Koutantos J., Rigatos S. Lung carcinoid tumor biology: treatment and survival. Oncol Rep. 2009;21:757–60. doi: 10.3892/or_00000281.

50. Rizzardi G.G., Marulli L., Bortolotti F., Calabrese F., Sartori F., Rea F. Sleeve resections and bronchoplastic procedures in typical central carcinoid tumors. Thorac Cardiovasc Surg. 2008;56:42–5. doi: 10.1055/s-2007-965741.

51. Kanemoto A., Oshiro Y., Sugahara S., Kamagata S., Hirobe S., Toma M., Okumura T., Sakurai H. Proton beam therapy for inoperable recurrence of bronchial high-grade mucoepidermoid carcinoma. Jpn J Clin Oncol. 2012;42:552–5. doi: 10.1093/jjco/hys047.

52. Rizzardi G., Maruli G., Calabrese F., Rugge M., Rebusso A., Sartori F., Rea F. Bronchial carcinoid tumours in children: surgical treatment and outcome in a single institution. Eur J Pediatr Surg. 2009;19:228–31. doi: 10.1055/s-0029-1202857.

53. Marty-Ane C.H., Costes V., Pujol J.L., Alauzen M., Baldet P., Mary H. Carcinoid tumors of the lung: do atypical features require aggressive management? Ann Thorac Surg. 1995;59(1):78–83. doi: 10.1016/0003-4975(94)00630-P.

54. Manchua T.N., Guerreiro-Cardoso P.F., Camargo S.M., Signori L., Andrade C.F., Schneider Moreira A.L., da Silva Moreira J., Felicetti J.C., Camargo J.J. Surgical treatment of bronchial carcinoid tumors: a single-center experience. Lung Canc. 2010;70:158–62. doi: 10.1016/j.lungcan.2010.01.015.

55. Daddi N., Schiavon M., Filosso P.L., Cardillo G., Ambrogi M.C., De Palma A., Luzzi L., Bandiera A., Casali C., Ruff ato A., De Angelis V., Andriolo L.G., Guerrera F., Carleo F., Davini F., Urbani M., Mattioli S., Zannini P., Gotti G., Loizzi M., Puma F., Mussi A., Ricci A., Oliaro A., Rea F. Prognostic factors in a multicenter study of 247 atypical pulmonary carcinoids. Eur J Cardiothorac Surg. 2014;45:677–86. doi: 10.1093/ejcts/ezt470.

56. Degnan A.J., Tocchio S., Kurtom W., Tadros S.S. Pediatric neuroendocrine carcinoid tumors: management, pathology, and imaging fi ndings in a pediatric referral center. Pediatr Blood Canc. 2017;64:264–77. doi: 10.1002/pbc.26477.

57. Rizzardi G., Bertolaccini L., Terzi A. Bronchial carcinoid tumours in children – a review. Eur J Haematol. 2011;7(3):196–9. doi: 10.17925/EOH.2011.07.03.196.

58. Balzer B.W.R., Loo C., Lewis C.R., Trahair T.N., Anazodo A.C. Adenocarcinoma of the lung in childhood and adolescence: a systematic review. J Thorac Oncol. 2018;13(12):1832–41. doi: 10.1016/j.jtho.2018.08.2020.

59. Chin C.H., Huang C.C., Lin M.C., Chao T.Y., Liu S.F. Prognostic factors of tracheobronchial mucoepidermoid carcinoma – 15 years experience. Respirology. 2008;13:275–80. doi: 10.1111/j.1440-1843.2007.01207.x.

60. Ferguson M.K., Landreneau R.J., Hazelrigg S.R., Altorki N.K., Naunheim K.S., Zwischenberger J.B., Kent M., Yim A.P. Long-term outcome after resection for bronchial carcinoid tumors. Eur J Cardiothorac Surg. 2000;18(2):156–61. doi: 10.1016/s1010-7940(00)00493-0.

61. Techavichit P., Hicks M.J., Lopez-Terrada D.H., Quintanilla N.M., Guillerman R.P., Sarabia S.F., Sayeed J.G., Paulino A.C., Muscal J.A., Okcu M.F., Chintagumpala M. Mucoepidermoid carcinoma in children: a single institutional experience. Pediatr Blood Cancer. 2016;63(1):27–31. doi: 10.1002/pbc.25681.

62. Grigoletto V., Tagarelli A., Atzeni C., Cecchetto G., Indolfi P., De Pasquale M.D., De Leonardis F., Coppadoro B., Sorbara S., Chiaravalli S., Ferrari A., Bisogno G. Pleuropulmonary blastoma: a report from the TREP (Tumori Rari in Eta Pediatrica) Project. Tumori. 2020;106(2):126–32. doi: 10.1177/0300891619871344.