A case of successful use of a tandem regimen of high-dose polychemotherapy followed by autologous hematopoietic stem cell transplantation in a child with a refractory form of germ cell tumor
K. A. Sergeenko,
E. B. Machneva,
T. Z. Aliev,
N. A. Burlak,
O. A. Kapkova,
T. I. Potemkina,
K. V. Mitrakov,
A. P. Kazantsev,
A. S. Temnyy,
D. S. Smirnova,
I. Yu. Trushkova,
V. S. Ermakova,
P. A. Kerimov,
M. D. Malova,
N. G. Stepanyan,
G. B. Sagoya,
A. M. Suleymanova,
G. M. Muftakhova,
I. O. Kostareva,
M. V. Rubanskaya,
K. I. Kirgizov,
S. R. Varfolomeeva https://doi.org/10.21682/2311-1267-2025-12-1-62-69
Abstract
Germ cell tumors (GCTs) are a heterogeneous group of tumors that develop from pluripotent germ cells, diagnosed most often in infants, young children, adolescents and young adults, and are characterized by different localization, histological picture, clinical course and prognosis. Despite the fairly high efficiency of modern standard chemotherapy protocols for GCTs, the treatment of their relapses and refractory forms, which make up to 30–40 % of all GCTs and have an extremely unfavorable prognosis, is very difficult. Currently, there is no single strategy for the treatment of relapses and refractory forms of GCTs, however, the world and domestic literature presents data on the successful use of high-dose chemotherapy (HDCT) in such patients followed by autologous hematopoietic stem cell transplantation (auto-HSCT). To develop and optimize protocols for this therapy method, and therefore improve the treatment outcomes for patients with relapses and refractory forms of GCT, it is necessary to analyze a larger number of studies from various transplant centers working in this area. The article presents current literature data on the use of HDCT followed by auto-HSCT in patients with GCT, as well as a clinical case of successful 2 courses of HDCT with auto-HSCT in tandem mode in a child with a refractory form of GCT with subsequent maintenance of complete remission for 2 years.
About the Authors
K. A. Sergeenko
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
E. B. Machneva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia; Russian Children’s Clinical Hospital – Branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Hematologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov; Hematologist Department of Bone Marrow Transplantation
23 Kashirskoe Shosse, Moscow, 115522
117 Leninskiy Prosp., Moscow, 117997
T. Z. Aliev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
N. A. Burlak
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
O. A. Kapkova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Pediatric Oncology Department of Surgical Treatment Methods with Chemotherapy No. 1 (Head and Neck Tumors) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
T. I. Potemkina
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Hematologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
K. V. Mitrakov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Hematologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
A. P. Kazantsev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Head of the Children s Oncology Department of Surgical Treatment Methods with Chemotherapy (Young Children) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
A. S. Temnyy
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), pediatric oncologist Pediatric Oncology Department of Surgical Treatment Methods No. 2 (Tumors of the Thoracoabdominal Localization and Musculoskeletal System) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
D. S. Smirnova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
I. Yu. Trushkova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
V. S. Ermakova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Hematologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
P. A. Kerimov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Pediatric Oncology Department of Surgical Treatment Methods No. 2 (Tumors of the Thoracoabdominal Localization and Musculoskeletal System) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
M. D. Malova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Transfusiologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durno
23 Kashirskoe Shosse, Moscow, 115522
N. G. Stepanyan
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Transfusiologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
G. B. Sagoya
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Pediatric Oncology Department № 1 (Chemotherapy of Tumors of Thoracoabdominal Localization) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
A. M. Suleymanova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Pediatric Oncology Department № 1 (Chemotherapy of Tumors of Thoracoabdominal Localization) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
G. M. Muftakhova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Pediatric Oncologist Childrenʼs Oncology Department of Surgical Treatment Methods with Chemotherapy (Young Children) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
I. O. Kostareva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Pediatric Bone Marrow and Hematopoietic Stem Cell Transplantation of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
M. V. Rubanskaya
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of the Pediatric Oncology Department № 1 (Chemotherapy of Tumors of Thoracoabdominal Localization) of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
K. I. Kirgizov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Deputy Director for Scientific Work of Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
S. R. Varfolomeeva
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Director of the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov
23 Kashirskoe Shosse, Moscow, 115522
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Review
For citations:
Sergeenko K.A., Machneva E.B., Aliev T.Z., Burlak N.A., Kapkova O.A., Potemkina T.I., Mitrakov K.V., Kazantsev A.P., Temnyy A.S., Smirnova D.S., Trushkova I.Yu., Ermakova V.S., Kerimov P.A., Malova M.D., Stepanyan N.G., Sagoya G.B., Suleymanova A.M., Muftakhova G.M., Kostareva I.O., Rubanskaya M.V., Kirgizov K.I., Varfolomeeva S.R. A case of successful use of a tandem regimen of high-dose polychemotherapy followed by autologous hematopoietic stem cell transplantation in a child with a refractory form of germ cell tumor. Russian Journal of Pediatric Hematology and Oncology. 2025;12(1):62-69. (In Russ.) https://doi.org/10.21682/2311-1267-2025-12-1-62-69
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