Treatment of acute lymphoblastic leukemia in adolescents and young adults: the experience of the Moscow–Berlin

A. V. Pshonkin; Yu. V. Rumyantseva; D. V. Litvinov; A. F. Karelin; E. G. Boychenko; S. N. Lagoyko; O. I. Bydanov; L. I. Zharikova; O. V. Aleynikova; Ye. S. Tyutikova; M. A. Digoeva; O. R. Arakaev; O. V. Streneva; A. V. Shamardina; G. R. Sharapova; N. V. Myakova; N. I. Ponomareva; I. A. Khachatryan; K. L. Kondratchik; Ye. G. Mansurova; L. M. Minkina; Yu. V. Olshanskaya; N. B. Yudina; I. E. Gerbek; A. P. Shapochnik; A. I. Karachunskiy

doi:10.17650/2311-1267-2016-3-1-35-43

Treatment of acute lymphoblastic leukemia in adolescents and young adults: the experience of the Moscow–Berlin

A. V. Pshonkin, Yu. V. Rumyantseva, D. V. Litvinov, A. F. Karelin, E. G. Boychenko, S. N. Lagoyko, O. I. Bydanov, L. I. Zharikova, O. V. Aleynikova, Ye. S. Tyutikova, M. A. Digoeva, O. R. Arakaev, O. V. Streneva, A. V. Shamardina, G. R. Sharapova, N. V. Myakova, N. I. Ponomareva, I. A. Khachatryan, K. L. Kondratchik, Ye. G. Mansurova, L. M. Minkina, Yu. V. Olshanskaya, N. B. Yudina, I. E. Gerbek, A. P. Shapochnik, A. I. Karachunskiy

https://doi.org/10.17650/2311-1267-2016-3-1-35-43

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Abstract

One of the main risk-factors of acute lymphoblastic leukemia (ALL) is age. The most favorable age group is children from 2 to 9 years old, and the adolescents and young adults have the worst prognosis. Treatment of ALL at adolescents and young adults is a unique problem of modern hematology now. This work presents the analysis of 368 cases of patients with primary ALL 15–18 years old, which were registered in the database of Russian-Belarussian group from April 2002 to November 2014. The aim of the analysis was the estimation of effectiveness of different generations of protocol for adolescents and prognostic significance of different factors to reveal the ways of future therapy optimizing in this age group. Event-free survival of adolescents 15–18 years old according our study was 56 ± 5 % in ALL-MB-2002 study and 57 ± 6 % in ALL-MB-2008 study. We did not received any differences in survival based on immunophenotype of blast cells. But the risk group analysis showed the worst results at patients with ALL from pre-B-precursor cells of high risk. No difference was revealed according the gender. One of the general problems remains high toxicity of therapy at patients of this age group. Treatment related mortality (TRM) was 13.2 and 12 % at ALL-MB-2002 and ALL-MB-2008 accordingly. Main cause of deaths remains infection.

Keywords

acute lymphoblastic leukemia, adolescents, therapy effectiveness, survival, early response

About the Authors

A. V. Pshonkin

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

Yu. V. Rumyantseva

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia
Russian Federation

D. V. Litvinov

A. F. Karelin

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

E. G. Boychenko

City Children's Hospital № 1; Litera A, 14 Avangardnaya St., Saint Petersburg,198205, Russia
Russian Federation

S. N. Lagoyko

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

O. I. Bydanov

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia Republican Scientific Center of Pediatric Oncology, Hematology and Immunology, Ministry of Health of Republic of Belarus; 43 Frunzenskaya St., village Borovlyany, Borovljansky village council, Minsk district, 223053, Republic of Belarus
Russian Federation

L. I. Zharikova

O. V. Aleynikova

Republican Scientific Center of Pediatric Oncology, Hematology and Immunology, Ministry of Health of Republic of Belarus; 43 Frunzenskaya St., village Borovlyany, Borovljansky village council, Minsk district, 223053, Republic of Belarus
Russian Federation

Ye. S. Tyutikova

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

M. A. Digoeva

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

O. R. Arakaev

Regional Children's Clinical Hospital № 1;32 Serafimy Deryabinoy, Yekaterinburg, 620149, Russia
Russian Federation

O. V. Streneva

Regional Children's Clinical Hospital № 1;32 Serafimy Deryabinoy, Yekaterinburg, 620149, Russia
Russian Federation

A. V. Shamardina

Nizhny Novgorod Regional Children Hospital; 211 Vaneeva St., Nizhniy Novgorod, 603136, Russia
Russian Federation

G. R. Sharapova

Nizhnevartovsk District Clinical Children's Hospital; 30 Severnaya St., Nizhnevartovsk, Tyumen Oblast, Khanty-Mansi Autonomous Okrug, 628609, Russia
Russian Federation

N. V. Myakova

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

N. I. Ponomareva

Russian Children's Clinical Hospital, Ministry of Health of Russia; 117 Leninskiy Prosp., Moscow, 117997, Russia
Russian Federation

I. A. Khachatryan

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

K. L. Kondratchik

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia Morozov Children’s Hospital; 1/9 4th Dobryninskiy Per., Moscow, 119049, Russia
Russian Federation

Ye. G. Mansurova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia
Russian Federation

L. M. Minkina

Regional Children's Clinical Hospital № 1; 27 Ostryakova Prosp. Vladivostok, Primorsky Krai, 690078, Russia
Russian Federation

Yu. V. Olshanskaya

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117997, Russia
Russian Federation

N. B. Yudina

Voronezh Regional Children's Clinical Hospital № 1; 114 Lomonosova St., Voronezh, Voronezh Oblast, 394000, Russia
Russian Federation

I. E. Gerbek

Tomsk Regional Clinical Hospital; 96 Ivana Chernykh St., Tomsk, 634063, Russia
Russian Federation

A. P. Shapochnik

Orenburg Regional Clinical Oncology Center; 11 Gagarina Prosp., Orenburg, 460021, Russia
Russian Federation

A. I. Karachunskiy

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Review

For citations:

Pshonkin A.V., Rumyantseva Yu.V., Litvinov D.V., Karelin A.F., Boychenko E.G., Lagoyko S.N., Bydanov O.I., Zharikova L.I., Aleynikova O.V., Tyutikova Ye.S., Digoeva M.A., Arakaev O.R., Streneva O.V., Shamardina A.V., Sharapova G.R., Myakova N.V., Ponomareva N.I., Khachatryan I.A., Kondratchik K.L., Mansurova Ye.G., Minkina L.M., Olshanskaya Yu.V., Yudina N.B., Gerbek I.E., Shapochnik A.P., Karachunskiy A.I. Treatment of acute lymphoblastic leukemia in adolescents and young adults: the experience of the Moscow–Berlin. Russian Journal of Pediatric Hematology and Oncology. 2016;3(1):35-43. (In Russ.) https://doi.org/10.17650/2311-1267-2016-3-1-35-43

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)

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Russian Journal of Pediatric Hematology and Oncology

Treatment of acute lymphoblastic leukemia in adolescents and young adults: the experience of the Moscow–Berlin

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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