Клинический обзор анти-CD19 BiTE® и ex vivo данных об анти-CD33 BiTE® в качестве примеров ретаргетирования Т-клеток при гематологических опухолях

Блинатумомаб – биспецифичное антитело, созданное для воздействия на CD-19 клетки, является наиболее продвинутой частью биспецифических молекул, рекрутеров Т-клеток (BiTE®). Программа клинических исследований препарата включает такие нозологии, как В-клеточный острый лимфобластный лейкоз (ОЛЛ) и В-клеточную неходжкинскую лимфому (НХЛ). Достижения ремиссии удалось достичь как у взрослых, так и у детей с рефрактерным/рецидивирующим течением В-клеточного ОЛЛ, что позволило успешно выполнить аллогенную трансплантацию гемопоэтических стволовых клеток. Также блинатумомаб обладал стойким ответом к В-клеточной вялотекущей НХЛ. Блинатумомаб недавно получил одобрение FDA (США) для лечения рефрактерного/рецидивирующего ОЛЛ из клеток предшественников В-лимфоцитов, отрицательного по филадельфийской хромосоме. AMG 330 является исследовательским анти-CD33 BiTE®-антителом. Тестирование в режиме ex vivo на первичных образцах CD33-позитивных пациентов с острым миелоидным лейкозом показало экспансию и цитотоксический эффект против злокачественных клеток у AMG 330. 

Оригинальная статья “Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies” опубликована в журнале Mol Immunol 2015;67(2 Pt A):58–66. doi: 10.1016/j.molimm.2015.02.033. Epub 2015 Apr 13. Стиль и оформле- ние статьи сохранены. Все права защищены. © 2015 Elsevier Ltd.

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