Индивидуализированная терапия нейробластомы
https://doi.org/10.17650/2311-1267-2016-3-4-36-47
Аннотация
Нейробластома (НБ) – злокачественная эмбриональная опухоль детского возраста, характеризующаяся возможностью развития спонтанной регрессии у пациентов группы низкого риска или регрессии опухоли после проведения низкодозовой полихимиотерапии.
В отличие от больных указанной группы большинство пациентов группы высокого риска имеют крайне неблагоприятный прогноз, несмотря на проведение интенсивной мультимодальной терапии. Поэтому НБ является идеальной моделью для внедрения индивидуализированных терапевтических подходов. В течение многих лет пациентам с НБ проводилось риск-адаптированное лечение в соответствии с клиническими характеристиками заболевания и молекулярными особенностями опухоли на момент постановки диагноза.
В последнее время все большее значение приобретает внедрение подходов терапии, основанных на модификации лечения при проведении оценки ответа на проводимую терапию, а также использование таргетной молекулярной терапии, направленной против определенных молекулярно-генетических аномалий. Однако каждый терапевтический подход должен основываться на проспективных клинических исследованиях.
Об авторах
Т. Симон
Отделение детской онкологии и гематологии, Детская больница, Кельнский университет
Германия
Кельн, Германия
Германия
Кельн, Германия
М. Фишер
Отделение экспериментальной детской онкологии, Кельнский университет
Германия
Кельн, Германия
Германия
Кельн, Германия
Б. Херо
Отделение детской онкологии и гематологии, Детская больница, Кельнский университет
Германия
Кельн, Германия
Германия
Кельн, Германия
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Рецензия
Для цитирования:
Симон Т., Фишер М., Херо Б. Индивидуализированная терапия нейробластомы. Российский журнал детской гематологии и онкологии (РЖДГиО). 2016;3(4):36-47. https://doi.org/10.17650/2311-1267-2016-3-4-36-47
For citation:
Simon T., Fischer M., Hero B. Individualized therapy in neuroblastoma. Russian Journal of Pediatric Hematology and Oncology. 2016;3(4):36-47. https://doi.org/10.17650/2311-1267-2016-3-4-36-47
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