Анти-CD19-моноклональные антитела при острой лимфобластной лейкемии у детей
Аннотация
Разработка моноклональных антител для лечения гемобластозов является быстро развивающейся областью науки. Ряд соединений оказался эффективен при лечении острого лимфобластного лейкоза (ОЛЛ) у детей. В то время как неконъюгированные гуманизированные антитела хорошо переносимы и могут быть легко объединены с химиотерапией, иммуноконъюгаты, доставляющие токсические соединения прямо в клетки-мишени, имеют более серьезные побочные эффекты. Антигены с высокой и селективной экспрессией являются идеальными мишенями для использования антител и подходят для исследований фазы I/II и III при ОЛЛ у детей. Антигены, стабильно экспрессирующиеся на поверхности клетки, подходят как для неконъюгированных антител, вызывающих антитело-зависимую клеточную и комплемент-зависимую цитотоксичность, так и для биспецифических антител с участием Т-клеток. Моноклональные антитела обладают совершенно иным механизмом действия по сравнению с таковым обычной химиотерапии и, безусловно, способны существенно изменить стратегию лечения ОЛЛ в будущем.
Об авторах
А. И. Карачунский
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России;
Россия
117997, Москва, ул. Саморы Машела, 1
Россия
117997, Москва, ул. Саморы Машела, 1
Ю. В. Румянцева
ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России;
Россия
117997, Москва, ул. Саморы Машела, 1
Россия
117997, Москва, ул. Саморы Машела, 1
А. фон Штакельберг
Университетская клиника педиатрии, специализирующаяся в онкологии и гематологии, Университетского медицинского комплекса Шарите
Германия
Берлин
Германия
Берлин
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Для цитирования:
Карачунский А.И., Румянцева Ю.В., фон Штакельберг А. Анти-CD19-моноклональные антитела при острой лимфобластной лейкемии у детей. Российский журнал детской гематологии и онкологии (РЖДГиО). 2016;3(4):60-72. https://doi.org/10.17650/2311-1267-2016-3-4-60-72
For citation:
Karachunskiy A.I., Rumyantseva Y.V., fon Shtakelberg A. Anti-CD19 monoclonal antibodies in acute lymphoblastic leukemia in children. Russian Journal of Pediatric Hematology and Oncology. 2016;3(4):60-72. (In Russ.) https://doi.org/10.17650/2311-1267-2016-3-4-60-72
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