NUT midline carcinoma – the first proven case of a child in the Republic of Belarus
https://doi.org/10.17650/2311-1267-2017-4-4-67-73
Abstract
NUT midline carcinoma (NMC) is a very rare, highly malignant disease with a specific cytogenetic abnormality t(15;19)(q14;p13.1). This tumor can occur throughout life, unfortunately, most cases are characterized by the presence of metastases at the time of diagnosis. There are clear cytogenetic and molecular-biological criterias for diagnosis. There are no specific standards of therapy that provide effective treatment of this pathology in the world. However, the presence of a chimeric oncogene characterizing the tumor is promising in terms of targeting drug research in the framework of international cooperation. It is also necessary to collect information about this rare disease to analyze it and to identify the most effective therapy method. This article presents an analysis of the clinical case of NMC, first diagnosed in a child of 9-yearsold in the Republic of Belarus.
About the Authors
I. V. Proleskovskaya
Republican Center for Pediatric Oncology, Hematology and Immunology
Belarus
Belarus
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
T. M. Mikhalevskaya
Republican Center for Pediatric Oncology, Hematology and Immunology
Belarus
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
Belarus
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
O. V. Aleinikova
Republican Center for Pediatric Oncology, Hematology and Immunology
Belarus
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
Belarus
43 Frunzenskaya St., Borovlyany village, Minsk district, Minsk region, 223053, Republic of Belarus
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Review
For citations:
Proleskovskaya I.V., Mikhalevskaya T.M., Aleinikova O.V. NUT midline carcinoma – the first proven case of a child in the Republic of Belarus. Russian Journal of Pediatric Hematology and Oncology. 2017;4(4):67-73. (In Russ.) https://doi.org/10.17650/2311-1267-2017-4-4-67-73
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