Случай развития костной токсичности, имитирующей рецидив основного заболевания, у ребенка с нейробластомой на фоне терапии 13-цис-Ретиноевой кислотой

В статье представлен случай развития поражения костной ткани как проявление токсичности на фоне проведения дифференцировочной терапии 13-цис-Ретиноевой кислотой у пациента с нейробластомой (НБ) группы высокого риска. Данный клинический пример представляет собой интерес как модель дифференциального диагноза метастатического поражения костной ткани у пациентов с диссеминированной НБ и редкого варианта костной токсичности на фоне проведения специфической терапии.

1. Goodman M.S., Gurney J.G., Smith M.A. еt al. Sympathetic nervous system tumors. In: Ries L.A.G., Smith M.A., Gurney J.G. (eds.). Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. National Cancer Institute, SEER Program. NIH Pub. No. 99- 4649. Bethesda, MD; 1999. Pp. 65-72.

2. Peinemann F., van Dalen E.C., Enk H., Berthold F. Retinoic acid postconsolidation therapy for high-risk neuroblastoma patients treated with autologous haematopoietic stem cell transplantation. Cochrane Database Syst Rev 2017;8:CD010685. https://doi.org/10.1002/14651858.CD010685.pub3.

3. Spix C., Pastore G., Sankila R. et al. Neuroblastoma incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006;42(13):2081-91. https://doi.org/10.1016/j. ejca.2006.05.008.

4. Kushner B.H., LaQuaglia M.P., Bonilla M. A. et al. Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age. J Clin Oncol 1994;12(12):2607-13. https://doi.org/10.1200/JCO.1994.12.12.2607

5. Seeger R.C., Reynolds C.P. Neuroblastoma. In: Bone Marrow Transplantation. Edited by S.J. Forman, K.G. Blume, E.D. Thomas. Cambridg, England: Blacwell, 1994. Pp. 814-826.

6. Matthay K.K., Vallablanca I.G., Seeger R.S. et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer Group. N Engl J Med 1999;341(16):1165- 73. https://doi.org/10.1056/NEJM199910143411601.

7. Ikeda H., August C.S., Goldwein J.W. et al. Sites of relapse in patient with neuroblastoma following bone marrow transplantation in relation to preparatory "debulking" treatments. J Pediatr Surg 1992;27(11):1438- 41. PMID: 1479507.

8. Villablanca J.G., Khan A.A., Avramis V.I. et al. Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation. J Clin Oncol 1995;13(4):894-901. https://doi.org/10.1200/ JCO.1995.13.4.894.

9. Gota V., Chinnaswamy G., Vora T. et al. Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients. Cancer Chemother Pharmacol 2016;78(4):763-8. https://doi.org/10.1007/s00280-016-3126-3.

10. Matthay K.K. Targeted isotretinoin in neuroblastoma: kinetics, genetics, or absorption. Clin Cancer Res 2013;19(2):311-3. https://doi.org/10.1158/1078-0432.CCR-12-3313.

11. Cross S.F., Pozza L.D., Munns C.F. Hypercalcemia and osteoblastic lesions induced by 13-cis-retinoic acid mimicking relapsed neuroblastoma. Pediatr Blood Cancer 2009;53(4):666-8. https://doi.org/10.1002/ pbc.22052.

12. Marabelle A., Sapin V., Rousseau R. Hypercalcemia and 13-cis-retinoic acid in post-consolidation therapy of neuroblastoma. Pediatr Blood Cancer 2009;52(2):280-3. https://doi.org/10.1002/ pbc.21768.

13. DiGiovanna J.J. Isotretinoin effects on bone. J Am Acad Dermatol 2001;45(5):S176-82. https://doi.org/10.1067/ mjd.2001.113721.

14. Atalay A., Altaykan A., Ergin G., Kutsal Y.G. Reversible sclerotic changes of lumbar spine and femur due to long-term oral Isotretinoin therapy. Rhuematol Int 2004;24(5):197-300. https://doi.org/10.1007/s00296- 003-0391-3.

15. van Beek E., Löwik C., Karperien M., Papapoulos S. Independent pathways in the modulation of osteoclastic resorptioin by intermediates of the mevalonate biosynthetic pathway: The role of the retinoic acid receptor. Bone 2006;38(2):167-71. https://doi.org/10.1016/j.bone.2005.08.011.

16. Suillington J., Choy L., Derynck R. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol 2002;159(1):135-46. https://doi.org/10.1083/ jcb.200204060.