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Use of intravenous immunoglobulins in pediatric hematology/oncology and hematopoietic stem cell transplantation: Properties and indications (federal centers’ experience)

https://doi.org/10.17650/2311-1267-2014-0-3-44-50

Abstract

This paper gives information on the structure of immunoglobulin molecules and the functions of each of them, as well as on the plasma levels of immunoglobulins. It provides basic requirements for the safety of intravenous immunoglobulins (IVVGs) and indications for their use in hematology/oncology and hematopoietic stem cell transplantation. Their doses, regimens, and possible adverse reactions are shown for a number of diseases. Moreover, the paper describes the experience with 10 % IVVGs in the federal center and gives brief clinical examples of the efficiency of using these agents.

About the Authors

K. I. Kirgizov
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; Russian Children’s Clinical Hospital, Ministry of Health of Russia
Russian Federation
Moscow


T. V. Shamanskaya
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
Russian Federation
Moscow


E. A. Pristanskova
Russian Children’s Clinical Hospital, Ministry of Health of Russia
Russian Federation
Moscow


V. V. Konstantinova
Russian Children’s Clinical Hospital, Ministry of Health of Russia
Russian Federation
Moscow


N. V. Sidorova
Russian Children’s Clinical Hospital, Ministry of Health of Russia
Russian Federation
Moscow


D. Yu. Kachanov
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
Russian Federation
Moscow


S. R. Varfolomeeva
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
Russian Federation
Moscow


E. V. Skorobogatova
Russian Children’s Clinical Hospital, Ministry of Health of Russia
Russian Federation
Moscow


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Review

For citations:


Kirgizov K.I., Shamanskaya T.V., Pristanskova E.A., Konstantinova V.V., Sidorova N.V., Kachanov D.Yu., Varfolomeeva S.R., Skorobogatova E.V. Use of intravenous immunoglobulins in pediatric hematology/oncology and hematopoietic stem cell transplantation: Properties and indications (federal centers’ experience). Russian Journal of Pediatric Hematology and Oncology. 2014;(3):44-50. (In Russ.) https://doi.org/10.17650/2311-1267-2014-0-3-44-50

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ISSN 2311-1267 (Print)
ISSN 2413-5496 (Online)
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