New insights into the blood clotting
https://doi.org/10.17650/2311-1267-2018-5-3-13-22
Abstract
In recent years, an active revision of ideas about the mechanisms of blood clotting has been performed. Traditional views were largely inaccurate, which is the main reason for the inconsistency of the modern standard set of coagulation tests. This set was found to be insensitive, especially to hypercoagulable disorders. In this paper, we consider modern concepts of how blood clotting occurs. From this consideration follows the need for a critical review of existing methods for assessing the status of hemostasis and a standard set of laboratory tests. The lecture ends with a brief examination of which methods are the most informative today and could form the basis of a new informative coagulation testing set.
Keywords
hemostasis,
thrombosis,
bleeding,
clotting,
thrombin,
stopping of thrombus growth,
procoagulant platelet,
hypercoagulation,
new insights into clotting
Supporting agencies: Russian Science Foundation, grant No. 16-14-00224
About the Authors
F. I. Ataullakhanov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, 117997; 1, Bldg. 2 Leninskie Gory St., Moscow, 119992; 4 Kosygina St., Moscow, 119991
A. G. Rumyantsev
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow, 117997; 1 Ostrovityanova St., Moscow, 117997
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For citations:
Ataullakhanov F.I., Rumyantsev A.G. New insights into the blood clotting. Russian Journal of Pediatric Hematology and Oncology. 2018;5(3):13-22. (In Russ.) https://doi.org/10.17650/2311-1267-2018-5-3-13-22
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