Case of successful treatment of neuroaspergillosis in oncological patient
https://doi.org/10.21682/2311-1267-2019-6-3-68-71
Abstract
Invasive mycoses caused by fungi of the genus Aspergillus, today remain an urgent clinical problem in oncological patients. In 10–20 % of patients with primary by aspergilloma can be detected in the Central nervous system. The article describes a case of neuroaspergillosis in an immunocompromised patient with choroid carcinoma of the right parietal-occipital lobe of the brain. Correct interpretation of risk factors, clinical symptoms and imaging techniques, early diagnosis with verification the pathological process, the use of fungistatic and fungicidal drugs allowed to avoid the negative consequences of fungal neuroinfection.
About the Authors
R. I. Izmozherova
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Clinical Resident of the Department of Chemotherapy and Combined Treatment of Malignant Tumors in Children, SPIN-code: 6824-8710
68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
S. A. Kuleva
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Chemotherapy and Combined Treatment of Malignant Tumors in Children, Leading Researcher of the Research Department of Innovative Therapeutic Oncology and Rehabilitation Methods, Professor of the Training and Methodology Department, SPIN-code: 3441-4820
68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
S. V. Ivanova
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Pediatric Oncologist Department of Chemotherapy and Combined Treatment of Malignant Tumors
in Children, SPIN-code: 7834-0152
68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
N. D. Faseeva
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Pediatric Oncologist Department of Chemotherapy and Combined Treatment of Malignant Tumors in Children
68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
S. A. Tyatkov
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Radiologist of Radiology Department; SPIN-code: 2925-2746
68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
References
1. Maschan A.A., Klyasova G.A., Veselov A.V. Overview of the recommendations of the American society for infectious diseases for the treatment of aspergillosis. Guidelines, 2008. Pp.133–170. (In Russ.)].
2. Klimko N., Kozlova Y., Khostelidi S., Shadrivova O., Borzova Y., Burygina E., Vasilieva N., Denning D.W. The burden of serious fungal diseases in Russia. Mycoses 2015;58 Suppl 5:58–62. doi: 10.1111/myc.12388.
3. Klimko N.N. Invasive aspergillosis in hematological and cancer patients. Onkogematologiya = Oncohematology 2006;1(1–2):97–107. (In Russ.)].
4. Cornillet A., Camus C., Nimubona S., Gandemer V., Tattevin P., Belleguic C., Chevrier S., Meunier C., Lebert C., Aupée M., CauletMaugendre S., Faucheux M., Lelong B., Leray E., Guiguen C., Gangneux J.P. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis. 2006;43(5):57–84. doi: 10.1086/505870.
5. Hoenigl M., Zollner-Schwetz I., Sill H., Linkesch W., Lass-Flörl C., Schnedl W.J., Krause R. Epidemiology of invasive fungal infections and rationale for antifungal therapy in patients with haematological malignancies. Mycoses 2011;54(5):454–9. doi: 10.1111/j.1439-0507.2010.01881.x.
6. Popova M.O., Ekushov K.A., Ayzsilnieks O.V., Volkova A.G., Pinegina O.N., Ignatieva S.M., Slesarchuk O.A., Vladovskaya M.D., Bondarenko S.N., Zubarovskaya L.S., Klimko N.N., Afanasyev B.V. Invasive fungal infections in recipients of allogeneic hematopoietic stem cell teens and young adults. Rossiyskiy zhurnal detskoy gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2016;3(1):44–51. (In Russ.) doi: 10.17650/2311-1267-2016-3-1-44-51
7. Klimko N.N. Mycoses: diagnosis and treatment. A guide for doctors. M.: Premier MT, 2008. 336 p. (In Russ.)
Review
For citations:
Izmozherova R.I., Kuleva S.A., Ivanova S.V., Faseeva N.D., Tyatkov S.A. Case of successful treatment of neuroaspergillosis in oncological patient. Russian Journal of Pediatric Hematology and Oncology. 2019;6(3):68-71. (In Russ.) https://doi.org/10.21682/2311-1267-2019-6-3-68-71
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