Focal nodular liver hyperplasia as a late complication that occurs after autologous hematopoietic stem cell transplantation in children with neuroblastoma (clinical case and literature review)
G. B. Sagoyan, 
T. V. Shamanskaya,
D. Yu. Kachanov,
T. N. Galyan,
A. V. Filin,
M. A. Rakov,
E. V. Feoktistova,
Yu. N. Likar,
S. R. Varfolomeeva
T. V. Shamanskaya,
D. Yu. Kachanov,
T. N. Galyan,
A. V. Filin,
M. A. Rakov,
E. V. Feoktistova,
Yu. N. Likar,
S. R. Varfolomeeva https://doi.org/10.21682/2311-1267-2019-6-3-94-102
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Abstract
Focal nodular hyperplasia (FNH) is a regenerative volumetric liver formation that can occur as a result of the reaction of hepatocytes to local vascular circulatory disorders and is one of the late complications in patients who received high-dose chemotherapy followed by hematopoietic stem cell transplantation. This article presents a description of two clinical cases of development of liver FNH in patients with high-risk neuroblastoma identified in the late stages from the end of specific treatment. A possible reason for the development of liver FNH in these patients could be the use of alkylating drugs (ifosfamide, threosulfan, busulfan, melphalan).
About the Authors
G. B. Sagoyan
Research Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Pediatric Oncologist Department of Surgery No. 2 (Tumors of Thoracoabdominal Localization) Research
23 Kashirskoe Shosse, Moscow, 115478
T. V. Shamanskaya
Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Academic Secretary of the Institute of Oncology, Radiology and Nuclear Medicine Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
2 Abrikosovsky per., Moscow, 119991
D. Yu. Kachanov
Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Clinical Oncology and Department of Embryonic Tumor Research & Deputy Director of the Institute of Oncology, Radiology and Nuclear Medicine at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
2 Abrikosovsky per., Moscow, 119991
T. N. Galyan
Bryansk Regional Children’s Hospital
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of the Department of Radiology and Computed Tomography Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia
100 Prosp. Stanke Dimitrova, Bryansk, 241033
A. V. Filin
Bryansk Regional Children’s Hospital
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of Liver Transplant Department Russian Scientific Center of Surgery named after. Academician B.V. Petrovsky, Ministry of Health of Russia
100 Prosp. Stanke Dimitrova, Bryansk, 241033
M. A. Rakov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation
Russian Federation
Head of Department of Hematology, Oncology and Chemotherapy Bryansk Regional Children’s Hospital
1 Samory Mashela St., Moscow, 117997
E. V. Feoktistova
Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of Department of Ultrasound Diagnostics Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
2 Abrikosovsky per., Moscow, 119991
Yu. N. Likar
Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of the Department of Radioisotope Diagnostics and Positron Emission Tomography Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
2 Abrikosovsky per., Moscow, 119991
S. R. Varfolomeeva
Research Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Deputy Director for Research and Clinical Work – Director of the Research Institute of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Executive Director of Regional Public Organization National Society of Pediatric Hematologists and Oncologists
23 Kashirskoe Shosse, Moscow, 115478
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Review
For citations:
Sagoyan G.B., Shamanskaya T.V., Kachanov D.Yu., Galyan T.N., Filin A.V., Rakov M.A., Feoktistova E.V., Likar Yu.N., Varfolomeeva S.R. Focal nodular liver hyperplasia as a late complication that occurs after autologous hematopoietic stem cell transplantation in children with neuroblastoma (clinical case and literature review). Russian Journal of Pediatric Hematology and Oncology. 2019;6(3):94-102. (In Russ.) https://doi.org/10.21682/2311-1267-2019-6-3-94-102
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ISSN 2413-5496 (Online)
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